UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5420-5425

  Langkjær, Niels ^a   Pasternak, Anna ^a   Wengel, Jesper ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Oligonucleotide; RNA mimic; Seco RNA; UNA; Unlocked nucleic acid

Indexed keywords

LOCKED NUCLEIC ACID; MONOMER; NUCLEIC ACID; OLIGONUCLEOTIDE; RNA DERIVATIVE; RNA MIMIC AGENT; UNCLASSIFIED DRUG; UNLOCKED NUCLEIC ACID;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; MASS SPECTROMETRY; NUCLEIC ACID ANALYSIS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ADENINE; CIRCULAR DICHROISM; CYTOSINE; GUANINE; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; ORGANOPHOSPHORUS COMPOUNDS; RNA; RNA STABILITY; TEMPERATURE; URACIL;

EID: 67651112027     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.045     Document Type: Article

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