A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Nucleic Acids Research

Volumn 38, Issue 17, 2010, Pages 5761-5773

  Bramsen, Jesper B ^a   Pakula, Malgorzata M ^a   Hansen, Thomas B ^a   Bus, Claus ^a   Langkjær, Niels ^b   Odadzic, Dalibor ^c   Smicius, Romualdas ^c   Wengel, Suzy L ^d   Chattopadhyaya, Jyoti ^e   Engels, Joachim W ^c   Herdewijn, Piet ^f   Wengel, Jesper ^b   Kjems, Jørgen ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c GOETHE UNIVERSITY   (Germany)

^d RiboTask ApS   (Denmark)

^e UPPSALA UNIVERSITY   (Sweden)

^f REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; NUCLEIC ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UNLOCKED NUCLEIC ACID; COMPLEMENTARY RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CELL LINE; CHEMICAL MODIFICATION; CONTROLLED STUDY; GENE FUNCTION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; INHIBITION KINETICS; MAMMAL CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN TARGETING; REPORTER GENE; RNA INTERFERENCE; CHEMISTRY; TUMOR CELL LINE;

MAMMALIA;

CELL LINE, TUMOR; GENES, REPORTER; HUMANS; NUCLEIC ACIDS; RNA INTERFERENCE; RNA, ANTISENSE; RNA, SMALL INTERFERING;

EID: 77957241115     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq341     Document Type: Article

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