Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

Current Biology

Volumn 10, Issue 24, 2000, Pages 1565-1573

  Hekmat Nejad, Mohammad ^a   You, Zhongsheng ^b   Yee, Muh ching ^a   Newport, John W ^b   Cimprich, Karlene A ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; ATM PROTEIN; CHROMATIN; DACTINOMYCIN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA REPLICATION; GENE MUTATION; MITOSIS; PROTEIN BINDING; XENOPUS LAEVIS;

XENOPUS;

EID: 0034649590     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00855-1     Document Type: Article

References (40)

1. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus
2. Regulation of chromosome replication
3. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
4. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells
5. The G2 phase DNA damage checkpoint
6. PIK-related kinases: DNA repair, recombination and call cycle checkpoints
7. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
8. The Schizosaccharomyces pombe rad3 checkpoint gene
9. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
10. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
11. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
12. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
13. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
14. ATM-dependent phosphorylation of nibrin in response to radiation exposure
15. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
16. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
17. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
18. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
19. Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase
20. Cell-cycle extracts
21. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in call-free extracts
22. Checkpoints on the road to mitosis
23. Activation of the DNA replication checkpoint through RNA synthesis by primase
24. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
25. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle
26. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
27. Regulated chromosomal DNA replication in the absence of a nucleus
28. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase α
29. Regulation of replicon size in Xenopus egg extracts
30. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
31. Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice
32. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
33. Mammalian cell fusion: Induction of premature chromosome condensation in interphase nuclei
34. Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis
35. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
36. Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts
37. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
38. Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity
39. Cyclin Is degraded by the ubiquitin pathway
40. The use of Xenopus laevis interphase extracts to study genomic DNA replication