Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

Genes and Development

Volumn 16, Issue 2, 2002, Pages 198-208

  Zou, Lee ^a   Cortez, David ^a   Elledge, Stephen J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

ATR; Checkpoint; Chkl; Rad1 Rad9 Hus1 complex; Rad17

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DNA; PROTEIN KINASE; PROTEIN RAD1; RAD1 RAD9 HUS1 PROTEIN COMPLEX; RAD17 PROTEIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME SUBSTRATE; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ULTRAVIOLET IRRADIATION;

BASE SEQUENCE; CELL CYCLE PROTEINS; CHROMATIN; DNA PRIMERS; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SUBSTRATE SPECIFICITY;

ADENOVIRIDAE;

EID: 0037080675     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.950302     Document Type: Article

References (38)

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3. Human DNA damage checkpoint protein hRAD9 is a 3′ to 5′ exonuclease
4. Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage
5. Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex
6. ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits
7. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins
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9. ATR and ATRIP: Partners in checkpoint signaling
10. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
11. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
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13. Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
14. Substrate specificities and identification of putative substrates of ATM kinase family members
15. Recruitment of mec1 and ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
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17. The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes
18. Chk1 is an essential kinase that is regulated by ATR and required for the G(2)/M DNA damage checkpoint
19. BRCT domain-containing protein TopBP1 functions in DNA replication and damage response
20. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
21. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis
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25. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
26. A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease
27. Identification of a human homologue of the Schizosaccharomyces pombe radl7+ checkpoint gene
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33. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
34. Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex
35. Piel, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
36. Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress
37. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
38. The DNA damage response: Putting checkpoints in perspective