Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair

Molecular Cell

Volumn 2, Issue 2, 1998, Pages 223-232

  Sugasawa, Kaoru ^a,b   Ng, Jessica M Y ^a   Masutani, Chikahide ^c   Iwai, Shigenori ^d   Van Der Spek, Peter J ^a,e   Eker, André P M ^a   Hanaoka, Fumio ^b,c   Bootsma, Dirk ^a   Hoeijmakers, Jan H J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d BIOMOL ENG RESEARCH INSTITUTE   (Japan)

^e AKZO NOBEL CENTRAL RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BINDING PROTEIN; XERODERMA PIGMENTOSUM GROUP A PROTEIN; XPA PROTEIN, HUMAN; XPC PROTEIN, HUMAN;

ARTICLE; BINDING COMPETITION; BIOLOGICAL MODEL; CHEMISTRY; DNA DAMAGE; DNA REPAIR; GENETICS; GENOME; HUMAN; IN VITRO STUDY; MACROMOLECULE; METABOLISM; NUCLEOTIDE SEQUENCE; XERODERMA PIGMENTOSUM;

BASE SEQUENCE; BINDING, COMPETITIVE; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENOME, HUMAN; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; XERODERMA PIGMENTOSUM; XERODERMA PIGMENTOSUM GROUP A PROTEIN;

EID: 0032134423     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80132-X     Document Type: Article

References (43)

1. Aboussekhra, A., Biggerstaff, M., Shivji, M.K.K., Vilpo, J.A., Moncollin, V., Podust, V.N., Protic, M., Hübscher, U., Egly, J.-M., and Wood, R.D. (1995). Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell 80, 859-868.
2. Asahina, H., Kuraoka, I., Shirakawa, M., Morita, E.H., Miura, N., Miyamoto, I., Ohtsuka, E., Okada, Y., and Tanaka, K. (1994). The XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA damage. Mutat. Res. 315, 229-237.
3. Bohr, V.A., Smith, C.A., Okumoto, D.S., and Hanawalt, P.C. (1985). DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell 40, 359-369.
4. Bootsma, D., Kraemer, K.H., Cleaver, J., and Hoeijmakers, J.H.J. (1998). Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. In The Genetic Basis of Human Cancer, B. Vogelstein and K.W. Kinzler, eds. (New York: McGraw-Hill Book Co.), pp. 245-274.
5. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
6. Cooper, P.K., Nouspikel, T., Clarkson, S.G., and Leadon, S.A. (1997). Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Science 275, 990-993.
7. Evans, E., Moggs, J.G., Hwang, J.R., Egly, J.-M., and Wood, R.D. (1997). Mechanism of open complex and dual incision formation by human nucleotide excision repair factors. EMBO J. 16, 6559-6573.
8. Friedberg, E.C., Walker, G.G., and Siede, W. (1995). DNA Repair and Mutagenesis (Washington, D.C.: ASM Press).
9. Hansson, J., and Wood, R.D. (1989). Repair synthesis by human cell extracts in DNA damaged by cis-and trans-diamminedichloroplatinum(II). Nucleic Acids Res. 17, 8073-8091.
10. He, Z., Henricksen, L.A., Wold, M.S., and Ingles, C.J. (1995). RPA involvement in the damage-recognition steps of nucleotide excision repair. Nature 374, 566-569.
11. Hendricksen, L.A., Umbricht, C.B.,and Wold, M.S. (1994). Recombinant replication protein A: expression, complex formation, and functional characterization. J. Biol. Chem. 269, 11121-11132.
12. Hwang, B.J., and Chu, G. (1993). Purification and characterization of a human protein that binds to damaged DNA. Biochemistry 32, 1657-1666.
13. Iwai, S., Shimizu, M., Kamiya, H., and Ohtsuka, E. (1996). Synthesis of a phosphoramidite coupling unit of the pyrimidine (6-4) pyrimidone photoproduct and its incorporation into oligonucleotides. J. Amer. Chem. Soc. 118, 7642-7643.
14. Jones, C.J., and Wood, R.D. (1993). Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA. Biochemistry 32, 12096-12104.
15. Leadon, S.A., and Cooper, P.K. (1993). Preferential repair of ionizing-radiation induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. Proc. Natl. Acad. Sci. USA 90, 10499-10503.
16. Legerski, R., and Peterson, C. (1992). Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. Nature 359, 70-73.
17. Masutani, C., Sugasawa, K., Yanagisawa, J., Sonoyama, T., Ui, M., Enomoto, T., Takio, K., Tanaka, K., van der Spek, P.J., Bootsma, D., et al. (1994). Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 13, 1831-1843.
18. Mellon, I., Spivak, G., and Hanawalt, P. (1987). Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell 51, 241-249.
19. Mitchell, D.L. (1988).The relativecytotoxicity of (6-4) photoproducts and cyclobutane dimers in mammalian cells. Photochem. Photobiol. 48, 51-57.
20. Morita, E.H., Ohkubo, T., Kuraoka, I., Shirakawa, M., Tanaka, K., and Morikawa, K. (1996). Implications of the zinc-finger motif found in the DNA-binding domain of the human XPA protein. Genes Cells 1, 437-442.
21. Mu, D., and Sancar, A. (1997). Model for XPC-independent transcription-coupled repair of pyrimidine dimers in humans. J. Biol. Chem. 272, 7570-7573.
22. Mu, D., Park, C.H., Matsunaga, T., Hsu, D.S., Reardon, J.T., and Sancar, A. (1995). Reconstitution of human DNA repair excision nuclease in a highly defined system. J. Biol. Chem. 270, 2415-2418.
23. Mu, D., Hsu, D.S., and Sancar, A. (1996). Reaction mechanism of human DN A repair excision nuclease. J. Biol. Chem. 271, 8285-8294.
24. Mu, D., Wakasugi, M., Hsu, D.S., and Sancar, A. (1997). Characterization of reaction intermediates of human excision repair nuclease. J. Biol. Chem. 272, 28971-28979.
25. Reardon, J.T., Nichols, A.F., Keeney, S., Smith, C.A., Taylor, J.-S., Linn, S., and Sancar, A. (1993). Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli damage recognition protein (UvrA) to the major ultraviolet photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T. J. Biol. Chem. 268, 21301-21308.
26. Reardon, J.T., Mu, D., and Sancar, A. (1996). Overproduction, purification, and characterization of the XPC subunit of the human DNA repair excision nuclease. J. Biol. Chem. 271, 19451-19456.
27. Sancar, A. (1996). DNA excision repair. Annu. Rev. Biochem. 65, 43-81.
28. Selby, C.P., and Sancar, A. (1993). Molecular mechanism of transcription-repair coupling. Science 260, 53-58.
29. Shivji, M.K.K., Eker, A.P.M., and Wood, R.D. (1994). DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells. J. Biol. Chem. 269, 22749-22757.
30. Shivji, M.K.K., Kenny, M.K., and Wood, R.D. (1992). Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69, 367-374.
31. Sugasawa, K., Masutani, C., Uchida, A., Maekawa, T., van der Spek, P.J., Bootsma, D., Hoeijmakers, J.H.J., and Hanaoka, F. (1996). HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro. Mol. Cell. Biol. 16, 4852-4861.
32. Sugasawa, K., Ng, J.M.Y., Masutani, C., Maekawa, T., Uchida, A., van der Spek, P.J., Eker, A.P.M., Rademakers, S., Visser, C., Aboussekhra, A., et al. (1997). Two human homologues of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol. Cell. Biol. 17, 6924-6931.
33. Tanaka, K., Miura, N., Satokata, I., Miyamoto, I., Yoshida, M.C., Satoh, S., Kondo, A., Yasui, A., Okayama, H., and Okada, Y. (1990). Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain. Nature 348, 73-76.
34. van Hoffen, A., Venema, J., Meschini, R., van Zeeland, A.A., and Mullenders, L.H.F. (1995). Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts. EMBO J. 14, 360-367.
35. Van Houten, B., Gamper, H., Sancar, A., and Hearst, J.E. (1987). DNase I footprint of ABC excinuclease. J. Biol. Chem. 262, 13180-13187.
36. van Oostrom, C.T.M., de Vries, A., Verbeek, S.J., van Krijl, C.F., and Versteeg, H. (1994). Cloning and characterization of the mouse XPAC gene. Nucleic Acids Res. 22, 11-14.
37. van Vuuren, A.J., Appeldoom, E., Odijk, H., Yasui, A., Jaspers, N.G.J., Bootsma, D., and Hoeijmakers, J.H. J. (1993). Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F. EMBO J. 12, 3693-3701.
38. Venema, J., van Hoffen, A., Natarajan, A.T., van Zeeland, A.A., and Mullenders, L.H.F. (1990). The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA. Nucleic Acids Res. 18, 443-448.
39. Venema, J., van Hoffen, A., Karcagi, V., Natarajan, A.T., van Zeeland, A.A., and Mullenders, L.H.F. (1991). Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes. Mol. Cell. Biol. 11, 4128-4134.
40. Visse, R., de Ruijter, M., Brouwer, J., Brandsma, J.A., and van de Putte, P. (1991). Uvr excision repair protein complex of Escherichia coli binds to the convex side of a cisplatin-induced kink in the DNA. J. Biol. Chem. 266, 7609-7617.
41. 6-methylguanine by ABC excinuclease of Escherichia coli in vitro. J. Biol. Chem. 264, 5172-5176.
42. Wood, R.D. (1996). DNA repair in eukaryotes. Annu. Rev. Biochem. 65, 135-167.
43. Wood, R.D., Robins, P., and Lindahl, T. (1988). Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts. Cell 53, 97-106.