메뉴 건너뛰기




Volumn 111, Issue 6, 2002, Pages 779-789

ATR regulates fragile site stability

Author keywords

[No Author keywords available]

Indexed keywords

ATM GENE; ATR GENE; CELL LINE; CHROMOSOME DELETION; CHROMOSOME FRAGILE SITE; CHROMOSOME REPLICATION; DNA REPLICATION; GENE; GENE REPLICATION; MAMMAL; METAPHASE CHROMOSOME; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0037074013     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)01113-3     Document Type: Article
Times cited : (494)

References (64)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2001;2177-2196.
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 2
    • 0029043548 scopus 로고
    • Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: A molecular switch for control of gene expression
    • Anton M., Graham F.L. Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein. a molecular switch for control of gene expression J. Virol. 69:1995;4600-4606.
    • (1995) J. Virol. , vol.69 , pp. 4600-4606
    • Anton, M.1    Graham, F.L.2
  • 3
    • 0036131979 scopus 로고    scopus 로고
    • Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
    • Arlt M.F., Miller D.E., Beer D.G., Glover T.W. Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells. Genes Chromosomes Cancer. 33:2002;82-92.
    • (2002) Genes Chromosomes Cancer , vol.33 , pp. 82-92
    • Arlt, M.F.1    Miller, D.E.2    Beer, D.G.3    Glover, T.W.4
  • 6
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown E.J., Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14:2000;397-402.
    • (2000) Genes Dev. , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 7
    • 0037178723 scopus 로고    scopus 로고
    • ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
    • Cha R.S., Kleckner N. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science. 297:2002;602-606.
    • (2002) Science , vol.297 , pp. 602-606
    • Cha, R.S.1    Kleckner, N.2
  • 8
    • 9244229490 scopus 로고    scopus 로고
    • CDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
    • Cimprich K.A., Shin T.B., Keith C.T., Schreiber S.L. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc. Natl. Acad. Sci. USA. 93:1996;2850-2855.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2850-2855
    • Cimprich, K.A.1    Shin, T.B.2    Keith, C.T.3    Schreiber, S.L.4
  • 9
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
    • Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., Friend S.H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17:1998;159-169.
    • (1998) EMBO J. , vol.17 , pp. 159-169
    • Cliby, W.A.1    Roberts, C.J.2    Cimprich, K.A.3    Stringer, C.M.4    Lamb, J.R.5    Schreiber, S.L.6    Friend, S.H.7
  • 10
    • 0030904279 scopus 로고    scopus 로고
    • Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
    • Coquelle A., Pipiras E., Toledo F., Buttin G., Debatisse M. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell. 89:1997;215-225.
    • (1997) Cell , vol.89 , pp. 215-225
    • Coquelle, A.1    Pipiras, E.2    Toledo, F.3    Buttin, G.4    Debatisse, M.5
  • 11
    • 0037096934 scopus 로고    scopus 로고
    • Identification of unstable sequences within the common fragile site at 3p14.2: Implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors
    • Corbin S., Neilly M.E., Espinosa R. III, Davis E.M., McKeithan T.W., Le Beau M.M. Identification of unstable sequences within the common fragile site at 3p14.2. implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors Cancer Res. 62:2002;3477-3484.
    • (2002) Cancer Res. , vol.62 , pp. 3477-3484
    • Corbin, S.1    Neilly, M.E.2    Espinosa R. III3    Davis, E.M.4    McKeithan, T.W.5    Le Beau, M.M.6
  • 12
    • 0035941021 scopus 로고    scopus 로고
    • Atr and atrip: Partners in checkpoint signaling
    • Cortez D., Guntuku S., Qin J., Elledge S.J. Atr and atrip. partners in checkpoint signaling Science. 294:2001;1713-1716.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 13
    • 0034306184 scopus 로고    scopus 로고
    • Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis
    • Dimitrova D.S., Gilbert D.M. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis. Nat. Cell Biol. 2:2000;686-694.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 686-694
    • Dimitrova, D.S.1    Gilbert, D.M.2
  • 16
    • 0035313706 scopus 로고    scopus 로고
    • DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
    • Durocher D., Jackson S.P. DNA-PK, ATM and ATR as sensors of DNA damage. variations on a theme? Curr. Opin. Cell Biol. 13:2001;225-231.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 225-231
    • Durocher, D.1    Jackson, S.P.2
  • 17
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 18
    • 0032242325 scopus 로고    scopus 로고
    • Instability at chromosomal fragile sites
    • Glover T.W. Instability at chromosomal fragile sites. Recent Results Cancer Res. 154:1998;185-199.
    • (1998) Recent Results Cancer Res. , vol.154 , pp. 185-199
    • Glover, T.W.1
  • 19
    • 0023614553 scopus 로고
    • Induction of sister chromatid exchanges at common fragile sites
    • Glover T.W., Stein C.K. Induction of sister chromatid exchanges at common fragile sites. Am. J. Hum. Genet. 41:1987;882-890.
    • (1987) Am. J. Hum. Genet. , vol.41 , pp. 882-890
    • Glover, T.W.1    Stein, C.K.2
  • 20
    • 0023789150 scopus 로고
    • Chromosome breakage and recombination at fragile sites
    • Glover T.W., Stein C.K. Chromosome breakage and recombination at fragile sites. Am. J. Hum. Genet. 43:1988;265-273.
    • (1988) Am. J. Hum. Genet. , vol.43 , pp. 265-273
    • Glover, T.W.1    Stein, C.K.2
  • 21
    • 0021278143 scopus 로고
    • DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
    • Glover T.W., Berger C., Coyle J., Echo B. DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet. 67:1984;136-142.
    • (1984) Hum. Genet. , vol.67 , pp. 136-142
    • Glover, T.W.1    Berger, C.2    Coyle, J.3    Echo, B.4
  • 22
    • 0022580241 scopus 로고
    • Fragile sites: Overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression
    • Glover T.W., Coyle-Morris J., Morgan R. Fragile sites. overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression Cancer Genet. Cytogenet. 19:1986;141-150.
    • (1986) Cancer Genet. Cytogenet. , vol.19 , pp. 141-150
    • Glover, T.W.1    Coyle-Morris, J.2    Morgan, R.3
  • 25
    • 0030894828 scopus 로고    scopus 로고
    • A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication
    • Hansen R.S., Canfield T.K., Fjeld A.D., Mumm S., Laird C.D., Gartler S.M. A variable domain of delayed replication in FRAXA fragile X chromosomes. X inactivation-like spread of late replication Proc. Natl. Acad. Sci. USA. 94:1997;4587-4592.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4587-4592
    • Hansen, R.S.1    Canfield, T.K.2    Fjeld, A.D.3    Mumm, S.4    Laird, C.D.5    Gartler, S.M.6
  • 26
    • 0035694237 scopus 로고    scopus 로고
    • Identification of essential genes in cultured mammalian cells using small interfering RNAs
    • Harborth J., Elbashir S.M., Bechert K., Tuschl T., Weber K. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J. Cell Sci. 114:2001;4557-4565.
    • (2001) J. Cell Sci. , vol.114 , pp. 4557-4565
    • Harborth, J.1    Elbashir, S.M.2    Bechert, K.3    Tuschl, T.4    Weber, K.5
  • 27
    • 0034117095 scopus 로고    scopus 로고
    • Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability
    • Hellman A., Rahat A., Scherer S.W., Darvasi A., Tsui L.-C., Kerem S. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability. Mol. Cell. Biol. 20:2000;4420-4427.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4420-4427
    • Hellman, A.1    Rahat, A.2    Scherer, S.W.3    Darvasi, A.4    Tsui, L.-C.5    Kerem, S.6
  • 29
    • 0035753424 scopus 로고    scopus 로고
    • FRA3B and other common fragile sites: The weakest links
    • Huebner K., Croce C.M. FRA3B and other common fragile sites. the weakest links Nat. Rev. Cancer. 1:2001;214-221.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 214-221
    • Huebner, K.1    Croce, C.M.2
  • 30
    • 0035955398 scopus 로고    scopus 로고
    • Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
    • Kondo T., Wakayama T., Naiki T., Matsumoto K., Sugimoto K. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science. 294:2001;867-870.
    • (2001) Science , vol.294 , pp. 867-870
    • Kondo, T.1    Wakayama, T.2    Naiki, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 31
    • 0031924605 scopus 로고    scopus 로고
    • Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: Implications for the mechanism of fragile site induction
    • Le Beau M.M., Rassool F.V., Neilly M.E., Espinosa R. III, Glover T.W., Smith D.I., McKeithan T.W. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction. implications for the mechanism of fragile site induction Hum. Mol. Genet. 7:1998;755-761.
    • (1998) Hum. Mol. Genet , vol.7 , pp. 755-761
    • Le Beau, M.M.1    Rassool, F.V.2    Neilly, M.E.3    Espinosa R. III4    Glover, T.W.5    Smith, D.I.6    McKeithan, T.W.7
  • 35
    • 0033847679 scopus 로고    scopus 로고
    • Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting
    • Masramon L., Ribas M., Cifuentes P., Arribas R., García F., Egozcue J., Peinado M.A., Miró R. Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting. Cancer Genet. Cytogenet. 121:2000;17-21.
    • (2000) Cancer Genet. Cytogenet. , vol.121 , pp. 17-21
    • Masramon, L.1    Ribas, M.2    Cifuentes, P.3    Arribas, R.4    García, F.5    Egozcue, J.6    Peinado, M.A.7    Miró, R.8
  • 36
    • 0030703564 scopus 로고    scopus 로고
    • Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas
    • Michael D., Beer D.G., Wilke C.W., Miller D.E., Glover T.W. Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas. Oncogene. 15:1997;1653-1659.
    • (1997) Oncogene , vol.15 , pp. 1653-1659
    • Michael, D.1    Beer, D.G.2    Wilke, C.W.3    Miller, D.E.4    Glover, T.W.5
  • 40
    • 0037040205 scopus 로고    scopus 로고
    • ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint
    • Nghiem P., Park P.K., Sim Y.-s., Desai B.N., Schreiber S.L. ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J. Biol. Chem. 277:2002;4428-4434.
    • (2002) J. Biol. Chem. , vol.277 , pp. 4428-4434
    • Nghiem, P.1    Park, P.K.2    Sim, Y.-S.3    Desai, B.N.4    Schreiber, S.L.5
  • 45
    • 17444440946 scopus 로고    scopus 로고
    • Common chromosomal fragile site FRA16D sequence: Identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells
    • Ried K., Finnis M., Hobson L., Mangelsdorf M., Sayan S., Nancarrow J.K., Woollatt E., Kremmidiotis G., Gardner A., Venter D.et al. Common chromosomal fragile site FRA16D sequence. identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells Hum. Mol. Genet. 9:2000;1651-1663.
    • (2000) Hum. Mol. Genet , vol.9 , pp. 1651-1663
    • Ried, K.1    Finnis, M.2    Hobson, L.3    Mangelsdorf, M.4    Sayan, S.5    Nancarrow, J.K.6    Woollatt, E.7    Kremmidiotis, G.8    Gardner, A.9    Venter, D.10
  • 46
    • 0032497529 scopus 로고    scopus 로고
    • A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
    • Santocanale C., Diffley J.F. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature. 395:1998;615-618.
    • (1998) Nature , vol.395 , pp. 615-618
    • Santocanale, C.1    Diffley, J.F.2
  • 49
    • 0025268820 scopus 로고
    • Common fragile sites in man and three closely related primate species
    • Smeets D.F.C.M., van de Klundert F.A.J.M. Common fragile sites in man and three closely related primate species. Cytogenet. Cell Genet. 53:1990;8-14.
    • (1990) Cytogenet. Cell Genet. , vol.53 , pp. 8-14
    • Smeets, D.F.C.M.1    Van de Klundert, F.A.J.M.2
  • 52
    • 0035797444 scopus 로고    scopus 로고
    • Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
    • Tercero J.A., Diffley J.F.X. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature. 412:2001;553-557.
    • (2001) Nature , vol.412 , pp. 553-557
    • Tercero, J.A.1    Diffley, J.F.X.2
  • 57
    • 0033051760 scopus 로고    scopus 로고
    • Allele-specific late replication and fragility of the most active common fragile site, FRA3B
    • Wang L., Darling J., Zhang J.-S., Huang H., Liu W., Smith D.I. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum. Mol. Genet. 8:1999;431-437.
    • (1999) Hum. Mol. Genet , vol.8 , pp. 431-437
    • Wang, L.1    Darling, J.2    Zhang, J.-S.3    Huang, H.4    Liu, W.5    Smith, D.I.6
  • 58
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward I.M., Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276:2001;47759-47762.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 59
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert T.A., Kiser G.L., Hartwell L.H. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8:1994;652-665.
    • (1994) Genes Dev. , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 60
    • 0030060945 scopus 로고    scopus 로고
    • FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: Direct evidence for the coincidence of viral integration sites and fragile sites
    • Wilke C.M., Hall B.K., Hoge A., Paradee W., Smith D.I., Glover T.W. FRA3B extends over a broad region and contains a spontaneous HPV16 integration site. direct evidence for the coincidence of viral integration sites and fragile sites Hum. Mol. Genet. 5:1996;187-195.
    • (1996) Hum. Mol. Genet , vol.5 , pp. 187-195
    • Wilke, C.M.1    Hall, B.K.2    Hoge, A.3    Paradee, W.4    Smith, D.I.5    Glover, T.W.6
  • 62
    • 0036510163 scopus 로고    scopus 로고
    • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    • Yarden R.I., Pardo-Reoyo S., Sgagias M., Cowan K.H., Brody L.C. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat. Genet. 30:2002;285-289.
    • (2002) Nat. Genet. , vol.30 , pp. 285-289
    • Yarden, R.I.1    Pardo-Reoyo, S.2    Sgagias, M.3    Cowan, K.H.4    Brody, L.C.5
  • 63
    • 0021690129 scopus 로고
    • Constitutive fragile sites and cancer
    • Yunis J.J., Soreng A.L. Constitutive fragile sites and cancer. Science. 226:1984;1199-1204.
    • (1984) Science , vol.226 , pp. 1199-1204
    • Yunis, J.J.1    Soreng, A.L.2
  • 64
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao H., Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21:2001;4129-4139.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.