The mammalian Mre11-Rad50,-Nbs1 protein complex: Integration of functions in the cellular DNA-damage response

American Journal of Human Genetics

Volumn 64, Issue 5, 1999, Pages 1264-1269

  Petrini, John H J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; DNA; IMMUNOGLOBULIN; NUCLEOTIDE; PROTEIN P53;

CELL CYCLE; COMPLEX FORMATION; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; DNA STRAND BREAKAGE; GENE; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

MAMMALIA;

EID: 0033358610     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302391     Document Type: Article

References (33)

1. Ajimura M, Leem SH, Ogawa H (1993) Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133:51-66
2. Bai Y, Symington L (1996) A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae. Genes Dev 10:2025-2037
3. Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR III, Hays L, et al (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93:477-486
4. Cleaver JE (1989) DNA repair in man. Birth Defects 25:61-82
5. Dolganov GM, Maser RS, Novikov A, Tosto L, Chong S, Bressan DA, Petrini JHJ (1996) Human Rad50 is physically associated with hMre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol Cell Biol 16:4832-4841
6. Fabre F, Boulet A, Roman H (1984) Gene conversion at different points in the mitotic cycle of Saccharomyces cerevisiae. Mol Gen Genet 195:139-143
7. Game JC (1993) DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces. Semin Cancer Biol 4:73-83
8. German J (1983) Patterns of neoplasia associated with the chromosome-breakage syndromes. In: Chromosome mutation & neoplasia. Alan R Liss, New York, pp 11-21
9. Haaf T, Golub EI, Reddy G, Radding CM, Ward DC (1995) Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci USA 92:2298-2302
10. Haber JE (1992) Exploring the pathways of homologous recombination. Curr Opin Cell Biol 4:401-412
11. Ivanov EL, Korolev VG, Fabre F (1992) XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination. Genetics 132:651-664
12. Jackson SP (1995) Cancer predisposition: ataxia-telangiectasia at the crossroads. Curr Biol 5:1210-1212
13. Jongmans W, Vuillaume M, Chrzanowska K, Smeets D, Sperling K, Hall J (1997) Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol Cell Biol 17:5016-5022
14. Kadyk LC, Hartwell LH (1992) Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics 132:387-402
15. Kolodner RD (1995) Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem Sci 20:397-401
16. Maizels N (1999) Immunoglobulin class-switch recombination: will genetics provide new clues to mechanism? Am J Hum Genet 64:1270-1275 (in this issue)
17. Maser RS, Bressan DA, Petrini JHJ (1999) The Mre11-Rad50 complex: diverse functions in the cellular DNA damage response. In: Hoekstra MF, Nickoloff JA (eds) DNA damageand repair. Vol. 3. Humana Press, Totowa, NJ
18. Maser RS, Monsen KJ, Nelms BE, Petrini JHJ (1997) hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double strand breaks. Mol Cell Biol 17:6087-6096
19. Moore JK, Haber JE (1996) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell Biol 16:2164-2173
20. Nelms BE, Maser RS, MacKay JF, Lagally MG, Petrini JHJ (1998) In situ visualization of DNA double-strand break repair in human fibroblasts. Science 280:590-592
21. Nove J, Little JB, Mayer PJ, Troilo P, Nichols WW (1986) Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents. Mutat Res 163:255-262
22. Petrini JH, Bressan DA, Yao MS (1997) The RAD52 epistasis group in mammalian double strand break repair. Semin Immunol 9:181-188
23. Rowley JD (1994) Chromosome translocations: dangerous liaisons. 1993 Robert R deVilliers Lecture. Leukemia 8 Suppl 1:51-S6
24. Schiestl RH, Zhu J, Petes TD (1994) Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae. Mol Cell Biol 14:4493-4500
25. Shiloh Y (1997) Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu Rev Genet 31:635-662
26. Stumm M, Sperling K, Wegner R-D (1997) Noncomplementation of radiation-induced chromosome aberrations in ataxia-telangiectasia/ataxia-telangiectasia-variant heterodikaryons. Am J Hum Genet 60:1246-1251
27. Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW (1983)The double-strand break repair model for recombination. Cell 33:25-35
28. Timme TL, Moses RE (1988) Diseases with DNA damage-processing defects. Am J Med Sci 295:40-48
29. Tsukamoto Y, Kato J, Ikeda H (1996) Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae. Genetics 142:383-391
30. van der Burgt I, Chrzanowska KH, Smeets D, Weemaes C (1996) Nijmegen breakage syndrome. J Med Genet 33:153-156
31. Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, Beckmann G, et al (1998) Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93:467-476
32. Xiao Y, Weaver DT (1997) Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res 25:2985-2991
33. Yamazaki V, Wegner RD, Kirchgessner CU (1998) Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells. Cancer Res 58:2316-2322