Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase

Molecular and Cellular Biology

Volumn 21, Issue 12, 2001, Pages 3853-3861

  Chen, Mei Shya ^a   Hurov, Jonathan ^a   White, Lynn S ^a   Woodford Thomas, Terry ^a   Piwnica Worms, Helen ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE; PROTEIN CDC25C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIVISION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME MECHANISM; ENZYME REGULATION; MITOSIS; MOUSE; NONHUMAN; OOCYTE DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SPERMATOGENESIS; TESTIS; THYMUS;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; DNA PRIMERS; FEMALE; FERTILITY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OOGENESIS; PHENOTYPE; SPERMATOGENESIS; T-LYMPHOCYTES; TISSUE DISTRIBUTION;

ANIMALIA; MURINAE; RODENTIA;

EID: 0034997233     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.12.3853-3861.2001     Document Type: Article

References (56)

1. Atherton-Fessler, S., F. Liu, B. Gabrielli, M. S. Lee, C.-Y. Peng, and H. Piwnica-Worms. 1994. Cell cycle regulation of the p34cdc2 inhibitory kinases. Mol. Biol. Cell 5:989-1001.
2. 1/S transition and leads to premature activation of cyclin E-and cyclin A-dependent kinases. Mol. Cell. Biol. 19:6183-6194.
3. Chamberlain, J. P. 1979. Fluorographic detection of radioactivity in polyacrylamide gels with the water soluble fluor sodium salicylate. Anal. Biochem. 98:132-135.
4. Chauhan, S., and M. Gottesman. 1992. Construction of a new universal vector for insertional mutagenesis by homologous recombination. Gene 120: 281-286.
5. Conklin, D. S., K. Galaktionov, and D. Beach. 1995. 14-3-3 proteins associate with cdc25 phosphatases. Proc. Natl. Acad. Sci. USA 92:7892-7896.
6. Dalal, S. N., C. M. Schweitzer, J. Gan, and J. Decaprio. 1999. Cytoplasmic localization of human Cdc25C during interphase requires an intact 14-3-3 binding site. Mol. Cell. Biol. 19:4465-4479.
7. Davezac, N., V. Baldin, B. Gabrielli, A. Forrest, N. Theis-Febvre, M. Yashida, and B. Ducommun. 2000. Regulation of CDC25B phosphatases subcellular localization. Oncogene 19:2179-2185.
8. Ducommun, B., G. Draetta, P. Young, and D. Beach. 1990. Fission yeast cdc25 is a cell cycle regulated protein. Biochem. Biophys. Res. Commun. 167:301-309.
9. Dunphy, W. G., and A. Kumagai. 1991. The cdc25 protein contains an intrinsic phosphatase activity. Cell 67:189-196.
10. Fantes, P. 1979. Epistatic gene interactions in the control of division in fission yeast. Nature 279:428-430.
11. Gabrielli, B. G., J. M. Clark, A. K. McCormack, and K. A. Ellem. 1997. Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2. J. Biol. Chem. 272:28607-28614.
12. Gabrielli, B. G., C. P. C. De Souza, I. D. Tonks, J. M. Clark, and N. K. Hayward. 1996. Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. J. Cell Sci. 109: 1081-1093.
13. Galaktionov, K., and D. Beach. 1991. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell 67:1181-1194.
14. Galaktionov, K., A. K. Lee, J. Eckstein, G. Draetta, J. Meckler, M. Loda, and D. Beach. 1995. CDC25 phosphatases as potential human oncogenes. Science 269:1575-1577.
15. Gasparotto, D., R. Maestro, S. Piccinin, T. Vukosavljevic, L. Barzan, S. Sulfaro, and M. Boiocchi. 1997. Overexpression of CDC25A and CDC25B in head and neck cancers. Cancer Res. 57:2366-2368.
16. Gautier, J., M. J. Solomon, R. N. Booher, J. F. Bazan, and M. W. Kirschner. 1991. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67:197-211.
17. Graves, P. R., C. M. Lovly, G. L. Uy, and H. Piwnica-Worms. 2001. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 binding. Oncogene, in press.
18. Graves, P. R., L. Yu, J. K. Schwarz, J. Gales, E. A. Sausville, P. M. O'Connor, and H. Piwnica-Worms. 2000. The Chk1 protein kinase and the Cdc25C regulatory pathway are targets of the anticancer agent UCN-01. J. Biol. Chem. 275:5600-5605.
19. Hernandez, S., L. Hernandez, S. Bea, M. Pinyol, I. Nayach, B. Bellosillo, A. Nadal, A. Ferrer, P. L. Fernandez, E. Montserrat, A. Cardesa, and E. Campo. 2000. Cdc25A and the splicing variant cdc25B2, but not cdc25B1, -B3 or -C, are over-expressed in aggressive human non-Hodgkin's lymphomas. Int. J. Cancer 89:148-152.
20. Hoffmann, I., P. R. Clarke, M. J. Marcote, E. karsenti, and G. Draetta. 1993. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 12:53-63.
21. Hoffmann, I., G. Draetta, and E. Karsenti. 1994. Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J. 13:4302-4310.
22. Honda, R., Y. Ohba, A. Nagata, H. Okayama, and H. Yasuda. 1993. Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase. FEBS Lett. 318:331-334.
23. Iavarone, A., and J. Massague. 1997. Repression of the CDK activator Cdc25A and cell-cycle arrest by the cytokine TGF-β in cells lacking the CDK inhibitor p 15. Nature 387:417-422.
24. Izumi, T., and J. L. Maller. 1993. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol. Biol. Cell 4:1337-1350.
25. Izumi, T., D. H. Walker, and J. M. Maller. 1992. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity. Mol. Biol. Cell 3:927-939.
26. Jinno, S., K. Suto, A. Nagata, M. Igarashi, Y. Kanaoka, H. Nojima, and H. Okayama. 1994. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 13:1549-1556.
27. Kakizuka, A., B. Sebastian, U. Borgmeyer, I. Hermans-Borgmeyer, J. Bolado, T. Hunter, M. F. Hoekstra, and R. M. Evans. 1992. A mouse cdc25 homolog is differentially and developmentally expressed. Genes Dev. 6:578-590.
28. Kuang, J., C. L. Ashorn, M. Gonzalez-Kuyvenhoven, and J. E. Penkala. 1994. cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor. Mol. Biol. Cell 5:135-145.
29. Kumagai, A., and W. G. Dunphy. 1996. Purification and molecular cloning of Plx1, a cdc25-regulatory kinase from Xenopus egg extracts. Science 273: 1377-1380.
30. Kumagai, A., and W. G. Dunphy. 1992. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell 70:139-151.
31. Kumagai, A., P. S. Yakowec, and W. G. Dunphy. 1998. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Mol. Biol. Cell 9:345-354.
32. Lammer, C., S. Wagerer, R. Saffrich, D. Mertens, W. Ansorge, and I. Hoffmann. 1998. The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J. Cell Sci. 111:2445-2453.
33. Lee, M. S., S. Ogg, M. Xu, L. L. Parker, D. J. Donoghue, J. L. Maller, and H. Piwnica-Worms. 1992. cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Mol. Biol. Cell 3:73-84.
34. Mailand, N., J. Falck, C. Lukas, R. G. Syljuasen, M. Welcker, J. Bartek, and J. Lukas. 2000. Rapid destruction of human Cdc25A in response to DNA damage. Science 288:1425-1429.
35. Millar, J. B. A., J. Blevitt, L. Gerace, K. Sadhu, C. Featherstone, and P. Russell. 1991. p55cdc25 is a nuclear protein required for the initiation of mitosis in human cells. Proc. Natl. Acad. Sci. USA 88:10500-10504.
36. Nagata, A., M. Igarashi, S. Jinno, K. Suto, and H. Okayama. 1991. An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. New Biol. 3:959-968.
37. Nargi, J. L., and T. A. Woodford-Thomas. 1994. Cloning and characterization of a cdc25 phosphatase from mouse lymphocytes. Immunogenetics 39: 99-108.
38. Nishijima, H., H. Nishitani, T. Seki, and T. Nishimoto. 1997. A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/ cyclin B activation in hamster BHK21 cells arrested with hydroxyurea. J. Cell Biol. 138:1105-1116.
39. + dependent manner. EMBO J. 10:1255-1263.
40. Peng, C.-Y., P. R. Graves, R. S. Thoma, Z. Wu, A. Shaw, and H. Piwnica-Worms. 1997. Mitotic-and G2-checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine 216. Science 277:1501-1505.
41. Piwnica-Worms, H. 1990. Expression of proteins in insect cells using baculovirus vectors. John Wiley & Sons, Inc., New York, N.Y.
42. + functions as an inducer in the mitotic control of fission yeast. Cell 45:145-153.
43. Sebastian, B., A. Kakizuka, and T. Hunter. 1993. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc. Natl. Acad. Sci. USA 90:3521-3524.
44. Sexl, V., J. Diehl, C. Sherr, R. Ashmun, D. Beach, and M. F. Roussel. 1999. A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene 18:573-582.
45. Solomon, M. J., T. Lee, and M. W. Kirschner. 1992. Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol. Biol. Cell 3:13-27.
46. Strausfeld, U., A. Fernandez, J.-P. Capony, F. Girard, N. Lautredou, J. Derancourt, J.-C. Labbe, and N. J. C. Lamb. 1994. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. J. Biol. Chem. 269:5989-6000.
47. Strausfeld, U., J. C. Labbe, D. Fesquet, J. C. Cavadore, A. Picard, K. Sadhu, P. Russell, and M. Doree. 1991. Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human cdc25 protein. Nature 351:242-245.
48. Takemasa, I., H. Yamamoto, M. Sekimoto, M. Ohue, S. Noura, Y. Miyake, T. Matsumoto, T. Aihara, N. Tomita, Y. Tamaki, I. Sakita, N. Kikkawa, N. Matsuura, H. Shiozaki, and M. Monden. 2000. Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma. Cancer Res. 60:3043-3050.
49. Terada, Y., M. Tatsuka, S. Jinno, and H. Okayama. 1995. Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation. Nature 376:358-362.
50. Villa-Moruzzi, E. 1993. Activation of the cdc25C phosphatase in mitotic HeLa cells. Biochem. Biophys. Res. Commun. 196:1248-1254.
51. Wickramasinghe, D., S. Becker, M. K. Ernst, J. L. Resnick, J. M. Centanni, L. Tessarollo, L. B. Grabel, and P. J. Donovan. 1995. Two CDC25 homologues are differentially expressed during mouse development. Development 121:2047-2056.
52. Wu, S., and D. J. Wolgemuth. 1995. The distinct and developmentally regulated patterns of expression of members of the mouse Cdc25 gene family suggest differential functions during gametogenesis. Dev. Biol. 170:195-206.
53. Wu, W., Y.-H. Fan, B. L. Kemp, G. Walsh, and L. Mao. 1998. Overexpression of cdc25A and cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc. Cancer Res. 58:4082-4085.
54. Yao, Y., E. D. Slosberg, L. Wang, H. Hibshoosh, U.-J. Zhang, W.-Q. Xing, R. M. Santella, and I. B. Weinstein. 1999. Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice. Oncogene 18:5159-5166.
55. Zeng, Y., K. C. Forbes, Z. Wu, S. Moreno, H. Piwnica-Worms, and T. Enoch. 1998. Replication checkpoint in fission yeast requires Cdc25p phosphorylation by Cds1p or Chk1p. Nature 395:507-510.
56. Zeng, Y., and H. Piwnica-Worms. 1999. The DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding. Mol. Cell. Biol. 19:7410-7419.