Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

Genes and Development

Volumn 15, Issue 14, 2001, Pages 1833-1844

  Lin, Weei Chin ^a   Lin, Fang Tsyr ^a   Nevins, Joseph R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; ATM; ATR; DNA damage; E2F1; P53

Indexed keywords

ATM PROTEIN; PHOSPHOTRANSFERASE; PROTEIN P53; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELL GROWTH; DNA DAMAGE; EMBRYO DEVELOPMENT; ENZYME SPECIFICITY; GENE INDUCTION; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; THYMOCYTE;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CISPLATIN; DNA DAMAGE; DNA-BINDING PROTEINS; DOXORUBICIN; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ETOPOSIDE; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; THYMUS GLAND; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0035878122     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Enhanced phosphorylation of p53 by ATM in response to DNA damage
2. ARF links the tumour suppressors RB and p53
3. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
4. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
5. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
6. Thymocyte apoptosis induced by p53-dependent and independent pathways
7. Distinct roles for E2F proteins in cell growth control and apoptosis
8. The regulation of E2F by pRB-family proteins
9. E2F-1 functions in mice to promote apoptosis and suppress proliferation
10. Degradation of E2F by the ubiquitin-proteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
11. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
12. Increased levels of E2F-1 dependent DNA binding activity after UV- or gamma-irradiation
13. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
14. Oncoprotein Mdm2 is a ubiquitin ligase E3 for tumor suppressor p53
15. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter
16. Role for E2F in DNA damage-induced entry of cells into S phase
17. Role for the p53 homologue p73 in E2F-1-induced apoptosis
18. Effects of an Rb mutation in the mouse
19. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
20. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
21. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p 19ARF
22. A mammalian cell cycle checkpoint pathway utilizing p52 and GADD45 is defective in ataxia-telangiectasia
23. Substrate specificities and identification of putative substrates of ATM kinase family members
24. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
25. E2F1-specific induction of apoptosis and p53 accumulation is modulated by mdm2
26. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
27. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
28. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase
29. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins
30. Myc requires distinct E2F activities to induce S phase and apoptosis
31. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
32. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
33. p53 is required for radiation-induced apoptosis in mouse thymocytes
34. Interaction between SCFSKP2 ubiquitin protein ligase and E2F-1 underlies regulation of E2F-1 degradation
35. p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin
36. Toward an understanding of the functional complexity of the E2F and Retinoblastoma families
37. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM
38. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
39. Induction of DNA synthesis and apoptosis are separable functions of E2F-1
40. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
41. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
42. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
43. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
44. Role of the p53 homologue p73 in E2F1-induced apoptosis
45. The caspase-Rb connection in cell death
46. A role for ATR in the DNA damage-induced phosphorylation of p53
47. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
48. CDC25A phosphatase is a target of E2F and is required for efficient E2f-induced S phase
49. Nucleolar Arf sequesters Mdm2 and activates p53
50. A family of mammalian F-box proteins
51. p53 and E2F-1 cooperate to mediate apoptosis
52. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rbl(+/-) mice
53. E2F3 contributes both to the inappropriate proliferation and to the apoptosis ariding in the Rb mutant embryos