The DNA replication checkpoint response stabilizes stalled replication forks

Nature

Volumn 412, Issue 6846, 2001, Pages 557-561

  Lopes, Massimo ^a,b   Cotta Ramusino, Cecilia ^a,b   Pellicioli, Achille ^a,b   Liberi, Giordano ^a,b   Plevani, Paolo ^a,b   Muzi Falconi, Marco ^a,b   Newlon, Carol S ^c   Foiani, Marco ^a,b  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYMES; GENES; MOLECULAR BIOLOGY; YEAST;

REPLICATION FORKS;

DNA;

DNA; HYDROXYUREA;

DNA;

ARTICLE; CELL CYCLE; DNA DAMAGE; DNA REPLICATION; DNA STRUCTURE; DNA SYNTHESIS; FLUORESCENCE ACTIVATED CELL SORTER; NONHUMAN; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE;

CELL CYCLE; CELL CYCLE PROTEINS; DNA REPLICATION; DNA, FUNGAL; ENZYME INHIBITORS; HYDROXYUREA; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEIC ACID SYNTHESIS INHIBITORS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REPLICATION ORIGIN; RIBONUCLEOTIDE REDUCTASES; SACCHAROMYCES CEREVISIAE PROTEINS; SACCHAROMYCETALES;

EUKARYOTA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0035797383     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35087613     Document Type: Article

References (29)

1. Cell cycle checkpoints: Preventing an identity crisis
2. DNA damage checkpoints update: Getting molecular
3. Sensing and responding to DNA damage
4. DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae
5. Yeast checkpoints controls and relevance to cancer
6. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
7. A checkpoint regulates the rate of progression through S-phase in S. cerevisiae in response to DNA damage
8. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
9. Regulation of DNA-replication origins during cell-cycle progression
10. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
11. The ATM homolog MEC1 is required for phosphorylation of replication protein A in yeast
12. Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and CDK1 activity
13. DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints
14. The localization of replication origins on ARS plasmids in S. cerevisiae
15. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
16. Analysis of replication origin function on chromosome III of Saccharomyces cerevisiae
17. Analysis of replication intermediates by two-dimensional agarose gel electrophoresis
18. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
19. A Rad3-Rad26 complex response to DNA damage independently of other checkpoint proteins
20. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis
21. RuvAB acts at arrested replication forks
22. Replication fork pausing and recombination or "gimme a break"
23. Initiation of DNA replication in ColE1 plasmids containing multiple potential origins of replication
24. Composite patterns in neutral/neutral two-dimensional gels demonstrate inefficient replication origin usage
25. DNA replication fork pause sites dependent on transcription
26. The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA
27. Elevated recombination rates in transcriptionally active DNA
28. Role for DNA primase in coupling DNA replication to DNA damage response
29. Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest