Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

Nature

Volumn 421, Issue 6925, 2003, Pages 859-863

  Aas, Per Arne ^a   Otterlei, Marit ^a   Falnes, Pål Ø ^b   Vågbø, Cathrine B ^a   Skorpen, Frank ^a   Akbari, Mansour ^a   Sundheim, Ottar ^a   Bjørås, Magnar ^b   Slupphaug, Geir ^a   Seeberg, Erling ^b   Krokan, Hans E ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; BACTERIA; BACTERIOPHAGES; CELLS; GENES; OXIDATION; RNA;

OXIDATIVE DEMETHYLATION;

DNA;

1 METHYLADENINE; CYTOSINE DERIVATIVE; DNA; DNA DEMETHYLASE; ENZYME; NUCLEIC ACID; RNA; UNCLASSIFIED DRUG;

DNA; RNA;

ALKYLATION; ARTICLE; BACTERIOPHAGE; CANCER; CELLULAR IMMUNITY; DEVELOPMENTAL DISORDER; DNA DAMAGE; DNA REPAIR; ESCHERICHIA COLI; HUMAN; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL;

ALKYLATION; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CELL LINE; CLONING, MOLECULAR; DNA; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; PROTEIN TRANSPORT; RNA; SEQUENCE ALIGNMENT; VIRUS ACTIVATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; UNIDENTIFIED BACTERIOPHAGE;

EID: 0037456369     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01363     Document Type: Article

References (27)

1. Friedberg, E. C., Walker, G. C. & Siede, W. DNA Repair and Mutagenesis (ASM, Washington DC, 1995).
2. Falnes, P. Ø., Johansen, R. F. & Seeberg, E. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419, 178-182 (2002).
3. Trewick, S. C., Henshaw, T. P., Hausinger, R. P., Lindabl, T. & Sedgwick, B. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419, 174-178 (2002).
4. Singer, B. & Grunberger, D. Molecular Biology of Mutagens and Carcinogens (Plenum, New York, 1983).
5. Boiteux, S. & Laval, J. Mutagenesis by alkylating agents: coding properties for DNA polymerase of poly(dC) template containing 3-methylcytosine. Biochimie 64, 637-641 (1982).
6. Saffhill, R. Differences in the promutagenic nature of 3-methylcytosine as revealed by DNA and RNA polymerising enzymes. Carcinogenesis 5, 691-693 (1984).
7. Rozenski, J., Crain, P. E. & McCloskey, J. A. The RNA Modification Database: 1999 update. Nucleic Acids Res. 27, 196-197 (1999).
8. 2+ in RNA structure and function. Prog. Nucleic Acid Res Mol. Biol. 53, 79-129 (1996).
9. Yoshizawa, S., Fourmy, D. & Puglisi, J. D. Recognition of the codon-anticodon helix by ribosomal RNA. Science 285, 1722-1725 (1999).
10. Matsugi, J. & Murao, K. Study on construction ofa cDNA library corresponding to an amino acid-specific tRNA and influence of the modified nucleotide upon nucleotide misincorporations in reverse transcription. Biochim. Biophys. Acta 1521, 81-88 (2001).
11. Haug, T. et al. Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q22-q24.1. Genomics 36, 408-416 (1996).
12. Wei, Y. F., Carter, K. C., Wang, R. P. & Shell, B. K. Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair. Nucleic Acids Res. 24, 931-937 (1996).
13. Aravind, L. & Koonin, E. V. The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol. 2, Research0007 [online] (http://genomebiology.com/2001/2/3/research/0007) (2001).
14. Myllyharju, J. & Kivirikko, K. I. Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase. EMBO J. 17, 1173-1180 (1997).
15. Valegård, K. et al. Structure ofa cephalosporin synthase. Nature 394, 805-809 (1998).
16. Nash, T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem. J. 55, 416-421 (1953).
17. + genes in Escherichia coli: identification of gene products and effects on alkylation resistance. J. Bacteriol. 168, 642-647 (1986).
18. Leonhardt, H. et al. Dynamics of DNA replication factories in living cells. J. Cell Biol. 149, 271-280 (2000).
19. Warner, J. R. Nascent ribosomes. Cell 107, 133-136 (2001).
20. Hartl, F. U. & Hayer-Hartl, M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295, 1852-1858 (2002).
21. Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning. A Laboratory Manual, 2nd edn (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989).
22. Yanisch-Perron, C., Vieira, J. & Messing, J. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33, 103-119 (1985).
23. Bjelland, S., Bjørås, M. & Seeberg, E. Excision of 3-methylguanine from alkylated DNA by 3-methyladenine DNA glycosylase I of Escherichia coli. Nucleic Acids Res. 21, 2045-2049 (1993).
24. Huang, X., Powell, J., Mooney, L. A., Li, C. & Frenkel, K. Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analyses. Free Radicals Biol. Med. 31, 1341-1351 (2001).
25. Crain, P. F. Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry. Methods Enzymol. 193, 782-790 (1990).
26. Blatny, J. M., Brautaset, T., Winther-Larsen, H. C., Haugan, K. & Valla, S. Construction and use of a versatile set of broad-host-range cloning and expression vectors based on the RK2 replicon. Appl. Environ. Microbiol. 63, 370-379 (1997).
27. Dinglay, S., Trewick, S. C., Lindahl, T. & Sedgwick, B. Defective processing of methylated single-stranded DNA by E. coli AlkB mutants. Genes Dev. 14, 2097-2105 (2000).