Mammalian G1- and S-phase checkpoints in response to DNA damage

Current Opinion in Cell Biology

Volumn 13, Issue 6, 2001, Pages 738-747

  Bartek, J ^a   Lukas, J ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CARCINOGENESIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DNA DAMAGE; GENE INDUCTION; GENETIC STABILITY; GENOME; GENOTOXICITY; HUMAN; MAMMAL; MITOSIS INHIBITION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

MAMMALIA;

EID: 0035545996     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00280-5     Document Type: Review

References (76)

1. Genome maintenance mechanisms for preventing cancer
2. Human DNA repair genes
3. Cell cycle control and cancer
4. The DNA damage response: Putting checkpoints in perspective
5. The many substrates and functions of ATM
6. DNA double-strand breaks: Signaling, repair and the cancer connection
7. ATM and ATR: Networking cellular responses to DNA damage
8. DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
9. Surfing the p53 network
10. The Mre11 complex and ATM: Collaborating to navigate S phase
11. Pathways governing G1/S transition and their response to DNA damage
12. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
13. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress response
14. Rapid destruction of Cdc25A in response to DNA damage
15. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage
16. The ATM-Chk2 Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
17. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
18. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
19. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
20. ATM-dependent phosphorylation of nibrin in response to radiation exposure
21. The retinoblastoma protein pathway and the restriction point
22. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
23. Involvement of Myc activity in a G1/S-promoting mechanism parallel to the pRb/E2F pathway
24. CDK inhibitors: Positive and negative regulators of G1-phase progression
25. The Rb/E2F pathway: Expanding roles and emerging paradigms
26. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle
27. Control of chromosomal DNA replication in the early Xenopus embryo
28. Accumulation of cyclin E is not a prerequisite for passage through the restriction point
29. pRB plays an essential role in cell cycle arrest induced by DNA damage
30. Regulation and function of the p53 tumor suppressor protein
31. Caffeine inhibits the checkpoint kinase ATM
32. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
33. p53 binds selectively to 5′ untranslated region of cdk4, an RNA element necessary for transforming growth factor beta- and p53-mediated translational inhibition of cdk4
34. SUMO-1 modification of Mdm2 prevents its selv-ubiquitination and increases Mdm2 ability to ubiquitinate p53
35. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
36. ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
37. p53 is associated with cellular microtubules and uses dynein-dependent transport for nuclear accumulation
38. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
39. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
40. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
41. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
42. The ARF/p53 pathway
43. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
44. CDKN2A expression in human skin
45. DNA replication: Building the perfect switch
46. p53 accumulates but is functionally impaired when DNA synthesis is blocked
47. Checking two steps
48. Radiation down-regulates replication origin activity throughout the S phase in mammalian cells
49. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
50. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
51. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks
52. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
53. Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
54. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
55. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
56. New link in a web of human genes
57. The Mre11 complex and DNA replication: Linkage to E2F and sites of DNA synthesis
58. Involvement of Brca1 in S-phase and G2 phase checkpoints after ionizing irradiation
59. In search of the tumour-suppressor functions of BRCA1 and BRCA2
60. The Pezcoller lecture: Cancer cell cycles revisited
61. Cell cycle. Piecing together the p53 puzzle
62. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
63. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
64. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
65. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
66. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis
67. CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers
68. Alterations of the double-strand break repair gene MRE11 in cancer
69. Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer
70. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
71. Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
72. Role of the Cdc25A phosphatase in human breast cancer
73. Abnormal expression of the ATM and TP53 genes in sporadic breast carcinomas
74. Specific protection against breast cancers by cyclin D1 ablation
75. Cell cycle checkpoint signalling through the ATM and ATR kinases
76. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation