메뉴 건너뛰기




Volumn 27, Issue 3, 2001, Pages 247-254

DNA double-strand breaks: Signaling, repair and the cancer connection

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DOUBLE STRANDED DNA; PROTEIN P53;

EID: 0035093737     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/85798     Document Type: Article
Times cited : (2055)

References (76)
  • 1
    • 0032493889 scopus 로고    scopus 로고
    • Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulates adaptation to G2/M arrest after DNA damage
    • (1998) Cell , vol.94 , pp. 399-409
    • Lee, S.E.1
  • 3
    • 0034613291 scopus 로고    scopus 로고
    • Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells
    • (2000) Science , vol.290 , pp. 138-141
    • Nikiforova, M.N.1
  • 8
    • 0034600975 scopus 로고    scopus 로고
    • Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells
    • (2000) EMBO J. , vol.19 , pp. 3398-3407
    • Johnson, R.D.1    Jasin, M.2
  • 11
    • 0032061317 scopus 로고    scopus 로고
    • XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
    • (1998) Mol. Cell , vol.1 , pp. 783-793
    • Liu, N.1
  • 12
    • 0030948789 scopus 로고    scopus 로고
    • Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination
    • (1997) Cell , vol.89 , pp. 195-204
    • Essers, J.1
  • 13
    • 0033519693 scopus 로고    scopus 로고
    • Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer
    • (1999) Oncogene , vol.18 , pp. 3422-3426
    • Hiramoto, T.1
  • 14
    • 0033519702 scopus 로고    scopus 로고
    • Mutations in the Rad54 recombination gene in primary cancer
    • (1999) Oncogene , vol.18 , pp. 3427-3430
    • Matsuda, M.1
  • 15
    • 0031741863 scopus 로고    scopus 로고
    • Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6423-6429
    • Rijkers, T.1
  • 16
    • 0033594509 scopus 로고    scopus 로고
    • DNA repair. Gatekeepers of recombination
    • (1999) Nature , vol.398 , pp. 665-667
    • Haber, J.E.1
  • 19
    • 0030933762 scopus 로고    scopus 로고
    • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
    • (1997) Nature , vol.386 , pp. 804-810
    • Sharan, S.K.1
  • 20
    • 0034697973 scopus 로고    scopus 로고
    • BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
    • (2000) Cell , vol.102 , pp. 257-265
    • Bochar, D.A.1
  • 21
    • 0033618621 scopus 로고    scopus 로고
    • Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
    • (1999) Science , vol.285 , pp. 747-750
    • Zhong, Q.1
  • 23
    • 0032587877 scopus 로고    scopus 로고
    • Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    • (1999) Nature Genet. , vol.22 , pp. 37-43
    • Xu, X.1
  • 24
    • 0033106326 scopus 로고    scopus 로고
    • 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • (1999) Mol. Cell , vol.3 , pp. 389-395
    • Xu, X.1
  • 25
    • 0033166981 scopus 로고    scopus 로고
    • Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2
    • (1999) Mol. Cell , vol.4 , pp. 1-10
    • Lee, H.1
  • 27
    • 0034612377 scopus 로고    scopus 로고
    • Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6664-6669
    • Petiniot, L.K.1
  • 29
    • 0034141562 scopus 로고    scopus 로고
    • The controlling role of ATM in homologous recombinational repair of DNA damage
    • (2000) EMBO J. , vol.19 , pp. 463-471
    • Morrison, C.1
  • 30
    • 18244421978 scopus 로고    scopus 로고
    • Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I
    • (1998) Development , vol.125 , pp. 4007-4017
    • Barlow, C.1
  • 34
    • 0034682736 scopus 로고    scopus 로고
    • Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
    • (2000) Cell , vol.102 , pp. 463-473
    • Ikura, T.1
  • 38
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1
  • 39
    • 0032076190 scopus 로고    scopus 로고
    • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
    • (1998) Cell , vol.93 , pp. 467-476
    • Varon, R.1
  • 40
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1
  • 41
    • 0034611728 scopus 로고    scopus 로고
    • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
    • (2000) Nature , vol.404 , pp. 613-617
    • Lim, D.S.1
  • 42
    • 0034106722 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of nibrin in response to radiation exposure
    • (2000) Nature Genet. , vol.25 , pp. 115-119
    • Gatei, M.1
  • 43
    • 0034713393 scopus 로고    scopus 로고
    • Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
    • (2000) Nature , vol.405 , pp. 473-477
    • Zhao, S.1
  • 44
    • 0034713466 scopus 로고    scopus 로고
    • ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
    • (2000) Nature , vol.405 , pp. 477-482
    • Wu, X.1
  • 45
    • 0033166623 scopus 로고    scopus 로고
    • Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
    • (1999) Curr. Biol. , vol.9 , pp. 699-702
    • Riballo, E.1
  • 46
    • 0034690249 scopus 로고    scopus 로고
    • Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
    • (2000) Nature , vol.404 , pp. 897-900
    • Gao, Y.1
  • 47
    • 0033634973 scopus 로고    scopus 로고
    • DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
    • (2000) Mol. Cell , vol.5 , pp. 993-1002
    • Frank, K.M.1
  • 48
    • 0034646304 scopus 로고    scopus 로고
    • Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2668-2673
    • Gu, Y.1
  • 50
    • 0032555458 scopus 로고    scopus 로고
    • Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development
    • (1998) Neurosci. Lett. , vol.252 , pp. 195-198
    • Oka, A.1    Takashima, S.2
  • 51
    • 0034732239 scopus 로고    scopus 로고
    • DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • (2000) Nature , vol.404 , pp. 510-514
    • Difilippantonio, M.J.1
  • 52
    • 0344541696 scopus 로고    scopus 로고
    • Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase
    • (1999) J. Clin. Invest. , vol.103 , pp. 1669-1675
    • Vanasse, G.J.1
  • 53
    • 0029858044 scopus 로고    scopus 로고
    • Mutations in the p53 and SCID genes cooperate in tumorigenesis
    • (1996) Genes Dev. , vol.10 , pp. 2055-2066
    • Nacht, M.1
  • 55
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
    • (2000) Nature , vol.404 , pp. 42-49
    • Tanaka, H.1
  • 58
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
    • (1998) EMBO J. , vol.2 , pp. 159-169
    • Cliby, W.A.1
  • 59
    • 0033555260 scopus 로고    scopus 로고
    • A role for ATR in the DNA damage-induced phosphorylation of p53
    • (1999) Genes Dev. , vol.13 , pp. 152-157
    • Tibbetts, R.S.1
  • 61
    • 0034177408 scopus 로고    scopus 로고
    • Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
    • (2000) Curr. Biol. , vol.10 , pp. 479-482
    • De Klein, A.1
  • 62
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
    • (1997) FASEB J. , vol.11 , pp. 68-76
    • Bork, P.1
  • 63
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • (2000) Genes Dev. , vol.14 , pp. 927-939
    • Wang, Y.1
  • 64
    • 0033612303 scopus 로고    scopus 로고
    • Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
    • (1999) Cell , vol.97 , pp. 575-586
    • Harkin, D.P.1
  • 65
    • 0034723347 scopus 로고    scopus 로고
    • BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression
    • (2000) J. Biol. Chem. , vol.275 , pp. 2777-2785
    • MacLachlan, T.K.1
  • 66
    • 0034616329 scopus 로고    scopus 로고
    • Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
    • (2000) J. Biol. Chem. , vol.275 , pp. 10342-10348
    • Zhou, B.-B.1
  • 68
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
    • (1997) Science , vol.277 , pp. 1497-1501
    • Sanchez, Y.1
  • 69
    • 0034659341 scopus 로고    scopus 로고
    • Aberrant cell cycle checkpoint function and early embryonic death in Chk1-l-mice
    • (2000) Genes Dev. , vol.12 , pp. 1439-1447
    • Takai, H.1
  • 70
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by ATR and required for the G2/M DNA damage checkpoint
    • (2000) Genes Dev. , vol.14 , pp. 1448-1459
    • Liu, Q.1
  • 74
    • 0034629072 scopus 로고    scopus 로고
    • DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    • (2000) Science , vol.287 , pp. 1824-1827
    • Hirao, A.1
  • 75
    • 0033601346 scopus 로고    scopus 로고
    • Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
    • (1999) Science , vol.286 , pp. 2528-2531
    • Bell, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.