Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Genes and Development

Volumn 14, Issue 23, 2000, Pages 2989-3002

  Tibbetts, Randal S ^a   Cortez, David ^b   Brumbaugh, Kathryn M ^a   Scully, Ralph ^c   Livingston, David ^c   Elledge, Stephen J ^b   Abraham, Robert T ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ATR; BRCA1; Checkpoint; DNA damage; Phosphorylation; Replication

Indexed keywords

APHIDICOLIN; ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; DNA; GENE PRODUCT; HYDROXYUREA; MUTANT PROTEIN; PROTEIN KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; FAMILIAL CANCER; GENE MUTATION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRESS; TUMOR SUPPRESSOR GENE;

ANIMALS; BRCA1 PROTEIN; CATALYSIS; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELL NUCLEUS; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; HUMANS; K562 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RABBITS; SERINE; SIGNAL TRANSDUCTION;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0033637170     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.851000     Document Type: Article

References (66)

1. BRCA1-associated growth arrest is RB-dependent
2. Enhanced phosphorylation of p53 by ATM in response to DNA damage
3. Atm-deficient mice: A paradigm of ataxia telangiectasia
4. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways
5. Radiosensitivity in ataxia-telangiectasia. Anomalies in radiation-induced cell cycle delay
6. Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation
7. The Schizosaccharomyces pombe rad3 checkpoint gene
8. Functions of the BRCA1 and BRCA2 genes
9. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
10. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle association with DNA replication sites
11. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
12. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
13. The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia
14. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
15. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
16. Transcriptional activation by BRCA1
17. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
18. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
19. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
20. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
21. Requirement of ATM-dependent phosphorylation of Brcal in the DNA damage response to double-strand breaks
22. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
23. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
24. The FHA domain is a modular phosphopeptide recognition motif
25. Genetic linkage analysis in familial breast and ovarian cancer results from 214 families The Breast Cancer Linkage Consortium
26. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination
27. Hydroxyurea induces recombination in dividing but not in G1 or G2 cell cycle arrested yeast cells
28. Role for ATM in DNA damage-reduced phosphorylation of BRCA1
29. BRCA1 required for transcription-coupled repair of oxidative DNA damage
30. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
31. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
32. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes
33. PIK-related kinases DNA repair, recombination, and cell cycle checkpoints
34. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells
35. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
36. Substrate specificities and identification of putative substrates of ATM kinase family members
37. The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
38. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
39. The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells
40. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
41. Evidence for a transcriptional activation function of BRCA1 C-terminal region
42. Brcal controls homology-directed DNA repair
43. BRCA1 is phosphorylated at Ser 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site
44. A Mecl- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
45. Location of BRCA1 in human breast and ovarian cancer cells
46. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
47. Association of BRCA1 with Rad51 in mitotic and meiotic cells
48. Genetic analysis of BRCA1 function in a defined tumor cell line
49. Interaction between ATM protein and c-Abl in response to DNA damage
50. DNA damage induces phosphorylation of the amino terminus of p53
51. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1
52. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
53. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles m the maintenance of chromosomal integrity in vertebrate cells
54. A role for ATR in the DNA damage-reduced phosphorylation of p53
55. Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier
56. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
57. Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms
58. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxacity
59. Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
60. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
61. Dual roles of ATM in the cellular response to radiation and in cell growth control
62. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
63. BRCA1, BRCA2, and DNA damage response- Collision or collusion?
64. Association of BRCA1 with the hRad50-hMrell-p95 complex and the DNA damage response
65. The DNA damage response: Putting checkpoints in perspective
66. Recombinant ATM protein complements the cellular A-T phenotype