DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts

Journal of Cell Biology

Volumn 158, Issue 5, 2002, Pages 863-872

  Stokes, Matthew P ^a   Van Hatten, Ruth ^a   Lindsay, Howard D ^b   Matthew Michael, W ^a  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Cell cycle; DNA damage; DNA replication; Rad 17; S phase

Indexed keywords

ALKYLATING AGENT; DNA; DOUBLE STRANDED DNA; MESYLIC ACID METHYL ESTER; PROTEIN KINASE; PROTEIN RAD17; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE S PHASE; CHROMATIN; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; FLUORESCENCE; MITOSIS; NONHUMAN; OOCYTE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPERM; XENOPUS;

ALKYLATION; ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL EXTRACTS; DNA DAMAGE; DNA REPLICATION; DNA-BINDING PROTEINS; FEMALE; MALE; OOCYTES; PROTEIN KINASES; S PHASE; XENOPUS; XENOPUS PROTEINS;

EID: 0037009006     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200204127     Document Type: Article

References (44)

1. Cell cycle checkpoint signaling through the ATM and ATR kinases
2. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
3. Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage
4. The importance of repairing stalled replication forks
5. A novel Rad24 checkpoint protein complex closely related to replication factor C
6. Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
7. Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends
8. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
9. The Cdc7/Dbf4 protein kinase: Target of the S phase checkpoint?
10. Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures
11. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
12. The Xenopus Chk1 protein/kinase mediates a caffeine-sensitive pathway of check-point control in cell-free extracts
13. Saccharomyces Ku70, mre11/red50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
14. Purification and characterization of human DNA damage checkpoint Rad complexes
15. Geminin, an inhibitor of DNA replication, is degraded during mitosis
16. A unified view of the DNA-damage checkpoint
17. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
18. Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Weel
19. Activation of the DNA replication checkpoint through RNA synthesis by primase
20. Replication fork arrest and DNA recombination
21. Cell cycle extracts
22. Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast
23. The G2-phase DNA-damage checkpoint
24. Inhibition of initiation of HeLa cell replicons by methyl methanesulfonate
25. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
26. RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage
27. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
28. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage
29. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
30. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints
31. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways
32. Regulation of DNA-replication origins during cell-cycle progression
33. RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae
34. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
35. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
36. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
37. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyper-phosphorylation and interacts with Rad53 after DNA damage
38. Regulated chromosomal DNA replication in the absence of a nucleus
39. The use of Xenopus laevis interphase egg extracts to study genomic DNA replication
40. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
41. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
42. The DNA damage response: Putting checkpoints in perspective
43. Regulation of ATR substrate selection by Radl7-dependent loading of Rad9 complexes onto chromatin