Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25

Science

Volumn 277, Issue 5331, 1997, Pages 1497-1501

  Sanchez, Yolanda ^a   Wong, Calvin ^a   Thoma, Richard S ^a   Richman, Ron ^a   Wu, Zhiqi ^a   Piwnica Worms, Helen ^a   Elledge, Stephen J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; DNA;

ARTICLE; CELL CYCLE; DEPHOSPHORYLATION; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCHIZOSACCHAROMYCES POMBE;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; ANIMALS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; CYTOSKELETAL PROTEINS; DNA DAMAGE; F-BOX PROTEINS; G2 PHASE; HELA CELLS; HUMANS; MICE; MITOSIS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RECOMBINANT FUSION PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TYROSINE 3-MONOOXYGENASE; UBIQUITIN-PROTEIN LIGASES;

EID: 0030867582     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5331.1497     Document Type: Article

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31. We thank A. Baldini for assistance with mapping; T. Carr for sharing unpublished information; P. Sen for making the S216A mutants of Cdc25C; N. Walworth, W. Harper, M. Huang, and J. Bachant for helpful comments; and D. Leibham and J. Thompson for technical assistance. Support was by a NIH postdoctoral fellowship GM17763 to Y.S. and a NIH grant GM44664 to S.J.E. H.P.-W. is an Associate Investigator of the Howard Hughes Medical Institute. S.J.E. is a Pew Scholar in the Biomedical Sciences and an Investigator of the Howard Hughes Medical Institute.