Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways

Journal of Cell Science

Volumn 113, Issue 22, 2000, Pages 3889-3896

  Rhind, N ^a   Russell, P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cds1; Chk1; Chk2; DNA damage checkpoint; Grp; Rad53; Replication checkpoint

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA; PROTEIN KINASE; UNCLASSIFIED DRUG;

CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA FLANKING REGION; DNA REPLICATION; DROSOPHILA; FROG; HUMAN; METAZOON; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; YEAST;

ANIMALS; CELL CYCLE; DNA DAMAGE; DNA REPLICATION; HUMANS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE;

ANURA; METAZOA; SCHIZOSACCHAROMYCES POMBE;

EID: 0034472434     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (97)

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13. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
14. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
15. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
16. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
17. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
18. The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: Implications for Chkl regulation
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20. The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast
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22. Cdc2 regulatory factors
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27. Cell cycle checkpoints: Preventing an identity crisis
28. The Drosophila grapes gene is related to checkpoint gene Chk1/rad27 and is required for late syncytial division fidelity
29. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
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31. An ATM homologue from arabidopsis thaliana: Complete genomic organisation and expression analysis
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40. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
41. An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage
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43. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
44. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
45. A cell cycle checkpoint monitors cell morphogenesis in budding yeast
46. Cell cycle control in Saccharomyces cerevisiae
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48. Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28
49. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
50. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
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64. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
65. Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis
66. The G2 DNA damage checkpoint targets both Wee1 and Cdc25
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76. The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition
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80. Drosophila grapes/Chk1 mutants are defective in cyclin proteolysis and coordination of mitotic events
81. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
82. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
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93. ATM-Related Genes: What do they tell us about functions of the human gene?
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96. DUN1 encodes a protein kinase that controls the DNA damage response in yeast