Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways

Journal of Cell Science

Volumn 113, Issue 22, 2000, Pages 3889-3896

  Rhind, N ^a   Russell, P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cds1; Chk1; Chk2; DNA damage checkpoint; Grp; Rad53; Replication checkpoint

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA; PROTEIN KINASE; UNCLASSIFIED DRUG;

CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA FLANKING REGION; DNA REPLICATION; DROSOPHILA; FROG; HUMAN; METAZOON; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; YEAST;

ANURA; METAZOA; SCHIZOSACCHAROMYCES POMBE;

EID: 0034472434     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.113.22.3889     Document Type: Note

References (97)

1. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast
2. Regulation of mitotic inhibitor mik1 helps to enforce the DNA damage checkpoint
3. Fission yeast wee1 protein kinase is not required for DNA damage-dependent mitotic arrest
4. Control of S-phase periodic transcription in the fission yeast mitotic cycle
5. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
6. The Schizosaccharomyces pombe Rad3 checkpoint gene
7. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
8. The role of inhibitory phosphorylation of Cdc2 following DNA replication block and radiation-induced damage in human cells
9. Replication checkpoint enforced by kinases Cds1 and Chk1
10. DNA replication checkpoint control
11. Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases
12. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
13. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
14. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
15. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
16. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
17. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
18. The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: Implications for Chkl regulation
19. Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis
20. The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast
21. The anaphase inhibitor of Saccharomyces cerevisiae Pds1 is a target of the DNA damage checkpoint pathway
22. Cdc2 regulatory factors
23. A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes
24. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
25. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
26. The FHA domain is a modular phosphopeptide recognition motif
27. Cell cycle checkpoints: Preventing an identity crisis
28. The Drosophila grapes gene is related to checkpoint gene Chk1/rad27 and is required for late syncytial division fidelity
29. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
30. Cdc25 mitotic inducer targeted by Chkl DNA damage checkpoint kinase
31. An ATM homologue from arabidopsis thaliana: Complete genomic organisation and expression analysis
32. RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast
33. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
34. Response of Xenopus cds1 in cell-free extracts to DNA templates with double-stranded ends
35. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
36. DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
37. Checkpoints: Controls that ensure the order of cell cycle events
38. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
39. The FHA domain: A putative nuclear signaling domain found in protein kinases and transcription factors
40. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
41. An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage
42. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
43. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
44. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
45. A cell cycle checkpoint monitors cell morphogenesis in budding yeast
46. Cell cycle control in Saccharomyces cerevisiae
47. Inactivation of the cyclin-dependent kinase Cdc28 abrogates cell cycle arrest induced by DNA damage and disassembly of mitotic spindles in Saccharomyces cerevisiae
48. Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28
49. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
50. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
51. Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest
52. DNA damage checkpoint in budding yeast
53. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
54. Rapid destruction of human Cdc25A in response to DNA damage
55. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
56. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
57. A kinase from fission yeast responsible for blocking mitosis in S phase
58. A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(Cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea
59. Chkl is a weel kinase in the G2 DNA damage checkpoint inhibiting Cdc2 by YI5 phosphorylation
60. Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216
61. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA
62. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
63. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
64. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
65. Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis
66. The G2 DNA damage checkpoint targets both Wee1 and Cdc25
67. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
68. Mitotic DNA damage and replication checkpoints in yeast
69. Tyrosine phosphorylation of Cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe
70. Control of the DNA damage checkpoint by Chk1 and rad53 protein kinases through distinct mechanisms
71. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
72. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
73. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
74. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
75. Regulation of DNA-replication origins during cell-cycle progression
76. The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition
77. DNA-replication checkpoint control at the Drosophila midblastula transition
78. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae
79. Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents
80. Drosophila grapes/Chk1 mutants are defective in cyclin proteolysis and coordination of mitotic events
81. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
82. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
83. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
84. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
85. Maintaining genetic stability through TP53 mediated checkpoint control
86. Fission yeast Chk1 protein kinase links the rad checkpoint pathway to Cdc2
87. rad-dependent response of the Chkl-encoded protein kinase at the DNA damage checkpoint
88. A DNA damage checkpoint meets the cell cycle engine
89. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
90. Cell-cycle signaling: Atm displays its many talents
91. Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
92. Pds1, an inhibitor of anaphase in budding yeast plays a critical role in the APC and checkpoint pathway(s)
93. ATM-Related Genes: What do they tell us about functions of the human gene?
94. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
95. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding
96. DUN1 encodes a protein kinase that controls the DNA damage response in yeast