Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint control

Molecular and Cellular Biology

Volumn 21, Issue 14, 2001, Pages 4495-4504

  Feng, W ^a   D'Urso, G ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; EXONUCLEASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE S PHASE; CELL VIABILITY; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; ENZYME SUBUNIT; GENE EXPRESSION; GENETIC CONSERVATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SCHIZOSACCHAROMYCES POMBE;

CATALYTIC DOMAIN; CELL CYCLE; DNA DAMAGE; DNA POLYMERASE II; GENE EXPRESSION; GENES, FUNGAL; HYDROXYUREA; METHYL METHANESULFONATE; MUTAGENESIS; MUTAGENS; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEIN KINASES; S PHASE; SCHIZOSACCHAROMYCES;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0034955240     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.14.4495-4504.2001     Document Type: Article

References (46)

1. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast
2. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe
3. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
4. DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae
5. Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae
6. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
7. DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae
8. Replication checkpoint enforced by kinases Cds1 and Chk1
9. DNA polymerases delta and epsilon are required for chromosomal replication in Saccharomyces cerevisiae
10. DNA structure checkpoint pathways in Schizosaccharomyces pombe
11. Role of the putative zinc finger domain of Saccharomyces cerevisiae DNA polymerase ε in DNA replication and the S/M checkpoint pathway
12. Analysis of the essential functions of the C-terminal protein/protein interaction domain of Saccharomyces cerevisiae pol epsilon and its unexpected ability to support growth in the absence of the DNA polymerase domain
13. Checkpoints in the cell cycle of fission yeast
14. + encodes DNA polymerase epsilon and is required for chromosomal replication bur not for the S phase checkpoint
15. Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme
16. Checkpoints: Controls that ensure the order of cell cycle events
17. Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases
18. A mammalian protein complex that repairs double-strand breaks and deletions by recombination
19. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication
20. Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe
21. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon
22. DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability
23. Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon
24. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon
25. S-phase-specific activation of Cds1 kinase defines a subpathway of checkpoint response in Schizosaccharomyces pombe
26. Mutator phenotype induced by aberrant replication
27. Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast
28. Thiamine-repressible expression vectors pREP and pRIP for fission yeast
29. Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: Dissection of DNA replication and G2 checkpoint control function
30. Central role for Cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts
31. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
32. A third essential DNA polymerase in S. cerevisiae
33. DNA replication and damage check-points and meiotic cell cycle controls in the fission and budding yeasts
34. Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe
35. CDC45 anal DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage
36. The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage
37. Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control
38. Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+
39. Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA
40. + is required for chromosomal DNA replication in the fission yeast Schizosaccharomyces pombe
41. Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast
42. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2
43. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae
44. DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae
45. DNA damage and checkpoint pathways: Molecular anatomy and interactions with repair
46. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin