Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25c on serine-216

Science

Volumn 277, Issue 5331, 1997, Pages 1501-1505

  Peng, Cheng Yuan ^a,b   Graves, Paul R ^a   Thoma, Richard S ^c   Wu, Zhiqi ^c   Shaw, Andrey S ^a   Piwnica Worms, Helen ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA DAMAGE; GAMMA IRRADIATION; HELA CELL; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; CELL CYCLE S PHASE; DNA REPLICATION; GAMMA RADIATION; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION;

CDC25C PROTEIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; HYBRID PROTEIN; PHOSPHOSERINE; PROTEIN; PROTEIN 14 3 3; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; TYROSINE 3 MONOOXYGENASE;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPLICATION; G2 PHASE; GAMMA RAYS; HELA CELLS; HUMANS; JURKAT CELLS; MITOSIS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASES; PROTEINS; RECOMBINANT FUSION PROTEINS; S PHASE; TYROSINE 3-MONOOXYGENASE;

EID: 0030611095     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5331.1501     Document Type: Article

References (31)

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31. We thank M. J. Byrnes for technical support, the laboratory of S. Dowdy for assistance with fluorescence-activated cell sorting analysis, T. Carr and T. Enoch for S. pombe Chk1 reagents, and T. Enoch for insightful discussions. Supported in part by NIH grants GM47017 (to H.P.-W.) and AI34094 (to A.S.S.) and training grant GM18428 (to P.R.G.). H.P.-W. is an Associate Investigator of the Howard Hughes Medical Institute.