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Volumn 17, Issue 5, 2003, Pages 615-628

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Author keywords

ATM; ATR; Cdc2; Checkpoints; Chk1; Chromosome breaks

Indexed keywords

ATM PROTEIN; ATR PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 0037335861     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1067403     Document Type: Article
Times cited : (420)

References (46)
  • 1
    • 0026562544 scopus 로고
    • DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe
    • Al-Khodairy, F. and Carr, A.M. 1992. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J. 11: 1343-1350.
    • (1992) EMBO J. , vol.11 , pp. 1343-1350
    • Al-Khodairy, F.1    Carr, A.M.2
  • 2
    • 0032496322 scopus 로고    scopus 로고
    • Replication checkpoint enforced by kinases Cds1 and Chk1
    • Boddy, M.N., Fumari, B., Mondesert, O., and Russell, P. 1998. Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280: 909-912.
    • (1998) Science , vol.280 , pp. 909-912
    • Boddy, M.N.1    Fumari, B.2    Mondesert, O.3    Russell, P.4
  • 3
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown, E.J. and Baltimore, D. 2000. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes & Dev. 14: 397-402.
    • (2000) Genes & Dev. , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 5
    • 0031874849 scopus 로고    scopus 로고
    • Improved properties of FLP recombinase evolved by cycling mutagenesis
    • Buchholz, F., Angrand, P.O., and Stewart, A.F. 1998. Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat. Biotechnol. 16: 657-662.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 657-662
    • Buchholz, F.1    Angrand, P.O.2    Stewart, A.F.3
  • 6
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma, S., Chen, B.P., Murphy, M., Kurimasa, A., and Chen, D.J. 2001. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276:42462-42467.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 7
    • 0037178718 scopus 로고    scopus 로고
    • Checking that replication breakdown is not terminal
    • Carr, A.M. 2002. Checking that replication breakdown is not terminal. Science 297: 557-558.
    • (2002) Science , vol.297 , pp. 557-558
    • Carr, A.M.1
  • 9
    • 0037178723 scopus 로고    scopus 로고
    • ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
    • Cha, R.S. and Kleckner, N. 2002. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297: 602-606.
    • (2002) Science , vol.297 , pp. 602-606
    • Cha, R.S.1    Kleckner, N.2
  • 10
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
    • Chao, C., Saito, S., Anderson, C.W., Appella, E., and Xu, Y. 2000. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc. Natl. Acad. Sci. 97: 11936-11941.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 12
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
    • Cliby, W.A., Roberts, C.J., Cimprich, K.A., Stringer, C.M., Lamb, J.R., Schreiber, S.L., and Friend, S.H. 1998. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17: 159-169.
    • (1998) EMBO J. , vol.17 , pp. 159-169
    • Cliby, W.A.1    Roberts, C.J.2    Cimprich, K.A.3    Stringer, C.M.4    Lamb, J.R.5    Schreiber, S.L.6    Friend, S.H.7
  • 13
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez, D., Guntuku, S., Qin, J., and Elledge, S.J. 2001. ATR and ATRIP: Partners in checkpoint signaling. Science 294: 1713-1716.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 15
    • 0034604329 scopus 로고    scopus 로고
    • Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans
    • De Souza, C.P., Osmani, A.H., Wu, LP., Spotts, J.L., and Osmani, S.A. 2000. Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans. Cell 102: 293-302.
    • (2000) Cell , vol.102 , pp. 293-302
    • De Souza, C.P.1    Osmani, A.H.2    Wu, L.P.3    Spotts, J.L.4    Osmani, S.A.5
  • 17
    • 0026482601 scopus 로고
    • Fission yeast genes involved in coupling mitosis to completion of DNA replication
    • Enoch, T., Carr, A.M., and Nurse, P. 1992. Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes & Dev. 6: 2035-2046.
    • (1992) Genes & Dev. , vol.6 , pp. 2035-2046
    • Enoch, T.1    Carr, A.M.2    Nurse, P.3
  • 18
    • 0031589555 scopus 로고    scopus 로고
    • Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains
    • Feil, R., Wagner, J., Metzger, D., and Chambon, P. 1997. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem. Biophys. Res. Commun. 237: 752-757.
    • (1997) Biochem. Biophys. Res. Commun. , vol.237 , pp. 752-757
    • Feil, R.1    Wagner, J.2    Metzger, D.3    Chambon, P.4
  • 19
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for ATR in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Guo, Z., Kumagal, A., Wang, S.X., and Dunphy, W.G. 2000. Requirement for ATR in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes & Dev. 14: 2745-2756.
    • (2000) Genes & Dev. , vol.14 , pp. 2745-2756
    • Guo, Z.1    Kumagal, A.2    Wang, S.X.3    Dunphy, W.G.4
  • 20
    • 0034649590 scopus 로고    scopus 로고
    • Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
    • Hekmat-Neiad, M., You, Z., Yee, M., Newport, J.W., and Cimprieh, K.A. 2000. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr. Biol. 10: 1565-1573.
    • (2000) Curr. Biol. , vol.10 , pp. 1565-1573
    • Hekmat-Neiad, M.1    You, Z.2    Yee, M.3    Newport, J.W.4    Cimprieh, K.A.5
  • 22
    • 0037224965 scopus 로고    scopus 로고
    • Checkpoint activation regulates mutagenic translesion synthesis
    • Kai, M. and Wang, T.S. 2003. Checkpoint activation regulates mutagenic translesion synthesis. Genes & Dev. 17: 64-76.
    • (2003) Genes & Dev. , vol.17 , pp. 64-76
    • Kai, M.1    Wang, T.S.2
  • 23
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan, M.B. and Lim, D.S. 2000. The many substrates and functions of ATM. Nat. Rev. Mol. Cell. Biol. 1: 179-186.
    • (2000) Nat. Rev. Mol. Cell. Biol. , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 24
    • 0029016412 scopus 로고
    • Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors
    • Kumagai, A. and Dunphy, W.G. 1995. Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors. Mol. Biol. Cell 6:199-213.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 199-213
    • Kumagai, A.1    Dunphy, W.G.2
  • 25
    • 0032555924 scopus 로고    scopus 로고
    • The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
    • Kumagai, A., Guo, Z., Emami, K.H., Wang, S.X., and Dunphy, W.G. 1998. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J. Cell Biol. 142: 1559-1569.
    • (1998) J. Cell Biol. , vol.142 , pp. 1559-1569
    • Kumagai, A.1    Guo, Z.2    Emami, K.H.3    Wang, S.X.4    Dunphy, W.G.5
  • 27
    • 0036468677 scopus 로고    scopus 로고
    • Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
    • Lois, C., Hong, E.J., Pease, S., Brown, E.J., and Baltimore, D. 2002. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295: 868-872.
    • (2002) Science , vol.295 , pp. 868-872
    • Lois, C.1    Hong, E.J.2    Pease, S.3    Brown, E.J.4    Baltimore, D.5
  • 29
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka, S., Huang, M., and Elledge, S.J. 1998. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-1897.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 30
    • 0035979213 scopus 로고    scopus 로고
    • ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
    • Nghiem, P., Park, P.K., Kim, Y., Vaziri, C., and Schreiber, S.L. 2001. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl. Acad. Sci. 98: 9092-9097.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 9092-9097
    • Nghiem, P.1    Park, P.K.2    Kim, Y.3    Vaziri, C.4    Schreiber, S.L.5
  • 31
    • 0037040205 scopus 로고    scopus 로고
    • ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint
    • Nghiem, P., Park, P.K., Kim, Y.S., Desai, B.N., and Schreiber, S.L. 2002. ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J. Biol. Chem. 277: 4428-4434.
    • (2002) J. Biol. Chem. , vol.277 , pp. 4428-4434
    • Nghiem, P.1    Park, P.K.2    Kim, Y.S.3    Desai, B.N.4    Schreiber, S.L.5
  • 32
    • 0026693966 scopus 로고
    • Animal cell cycles and their control
    • Norbury, C. and Nurse, P. 1992. Animal cell cycles and their control. Annu. Rev. Biochem. 61: 441-470.
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 441-470
    • Norbury, C.1    Nurse, P.2
  • 33
    • 0036948433 scopus 로고    scopus 로고
    • Toward maintaining the genome: DNA damage and replication checkpoints
    • Nyberg, K.A., Michelson, R.J., Putnam, C.W., and Weinert, T.A. 2002. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36: 617-656.
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 617-656
    • Nyberg, K.A.1    Michelson, R.J.2    Putnam, C.W.3    Weinert, T.A.4
  • 34
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull, T.T., Rogakou, E.P., Yamazaki, V., Kirchgessner, C.U., Gellert, M., and Bonner, W.M. 2000. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curt. Biol. 10: 886-895.
    • (2000) Curt. Biol. , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 35
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., and Bonner, W.M. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273: 5858-5868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 36
    • 0032861343 scopus 로고    scopus 로고
    • Megabasc chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou, E.P., Boon, C., Redon, C., and Bonner, W.M. 1999. Megabasc chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146: 905-916.
    • (1999) J. Cell Biol. , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 37
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
    • Comment 277: 1450-1451
    • Sanchez, Y., Wong, C., Thoma, R.S., Richman, R., Wu, Z., Piwnica-Worms, H., and Elledge, S.J. 1997. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25. Science 277: 1497-1501; Comment, 277: 1450-1451.
    • (1997) Science , vol.277 , pp. 1497-1501
    • Sanchez, Y.1    Wong, C.2    Thoma, R.S.3    Richman, R.4    Wu, Z.5    Piwnica-Worms, H.6    Elledge, S.J.7
  • 40
    • 0030829001 scopus 로고    scopus 로고
    • A DNA damage checkpoint meets the cell cycle engine
    • Weinert, T. 1997. A DNA damage checkpoint meets the cell cycle engine. Science 277:1450-1451.
    • (1997) Science , vol.277 , pp. 1450-1451
    • Weinert, T.1
  • 41
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T.A., Kiser, G.L., and Hartwell, L.H. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes & Dev. 8: 652-665.
    • (1994) Genes & Dev. , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 43
    • 0029821651 scopus 로고    scopus 로고
    • Dual roles of ATM in the cellular response to radiation and in cell growth control
    • Xu, Y. and Baltimore, D. 1996. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes & Dev. 10: 2401-2410.
    • (1996) Genes & Dev. , vol.10 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 44
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chkl
    • Zhao, H. and Piwnica-Worms, H. 2001. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chkl. Mol. Cell. Biol. 21: 4129-4139.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 45
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B.B. and Elledge, S.J. 2000. The DNA damage response: Putting checkpoints in perspective. Nature 408: 433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 46
    • 0037080675 scopus 로고    scopus 로고
    • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
    • Zou, L., Cortez, D., and Elledge, S.J. 2002. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes & Dev. 16: 198-208.
    • (2002) Genes & Dev. , vol.16 , pp. 198-208
    • Zou, L.1    Cortez, D.2    Elledge, S.J.3


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