The functions and structure of ABC transporters: Implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR)

Current Drug Targets

Volumn 7, Issue 7, 2006, Pages 893-909

  Teodori, Elisabetta ^a   Dei, S ^a   Martelli, C ^a   Scapecchi, S ^a   Gualtieri, F ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

ABC transporters; Chemosensitizers; Homology models; MDR reverters; MRP inhibitors; Multidrug resistance; Pgp inhibitors; X ray crystallography

Indexed keywords

5 [3 (4 DIPHENYLACETYL 1 PIPERAZINYL) 2 HYDROXYPROPOXY]QUINOLINE; ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ANNAMYCIN; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; ANTINEOPLASTIC AGENT; BIRICODAR; CATECHIN; DIPHENHYDRAMINE; DOXORUBICIN; ELACRIDAR; FLAVONOID; GLYCOPROTEIN P; LANIQUIDAR; LONAFARNIB; METHADONE; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PEPTIDE; SMALL INTERFERING RNA; SYNTHETIC PEPTIDE; TARIQUIDAR; TERFENADINE; TIMCODAR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSPODAR; VERAPAMIL; VX 853; ZOSUQUIDAR;

ANTIBIOTIC RESISTANCE; BIOCHEMISTRY; CANCER CHEMOTHERAPY; CLINICAL TRIAL; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; MAMMAL; MOLECULAR MODEL; MULTIDRUG RESISTANCE; PROKARYOTE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; UNSPECIFIED SIDE EFFECT;

ATP-BINDING CASSETTE TRANSPORTERS; CLINICAL TRIALS; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; HUMANS; MEMBRANE TRANSPORT MODULATORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN;

EID: 33745748312     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945006777709520     Document Type: Review

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