The MRP family of drug efflux pumps

Oncogene

Volumn 22, Issue 47 REV. ISS. 6, 2003, Pages 7537-7552

  Kruh, Gary D ^a   Belinsky, Martin G ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

ABC transporter; Efflux; Resistance

Indexed keywords

ABC TRANSPORTER; ADEFOVIR; ANTHRACYCLINE; BILE ACID; BUTHIONINE SULFOXIMINE; CAMPTOTHECIN; EPIPODOPHYLLOTOXIN; ETOPOSIDE; FLUOROURACIL; GLUCURONIC ACID; GLUTATHIONE; LEUKOTRIENE C4; MERCAPTOPURINE; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; MULTIDRUG RESISTANCE PROTEIN 7; MULTIDRUG RESISTANCE PROTEIN 8; MULTIDRUG RESISTANCE PROTEIN 9; NUCLEOSIDE DERIVATIVE; PEPTIDOLEUKOTRIENE; REDUCED FOLATE CARRIER; UNCLASSIFIED DRUG; VINCA ALKALOID; VINCRISTINE; ZALCITABINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CELL FUNCTION; DENDRITE; DRUG BINDING SITE; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; DUBIN JOHNSON SYNDROME; GENE CONTROL; GENE DISRUPTION; HUMAN; HYDROPHOBICITY; INFLAMMATION; LIPOPHILICITY; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PSEUDOXANTHOMA ELASTICUM; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; DRUG RESISTANCE, NEOPLASM; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN STRUCTURE, TERTIARY;

VINCA;

EID: 0345724724     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206953     Document Type: Review

References (184)

1. Adachi M, Sampath J, Lan LB, Sun D, Hargrove P, Flatley R, Tatum A, Edwards MZ, Wezeman M, Matherly L, Drake R and Schuetz J. (2002). J. Biol. Chem., 277, 38998-39004.
2. Allen JD, Brinkhuis RF, van Deemter L, Wijnholds J and Schinkel AH. (2000). Cancer Res., 60, 5761-5766.
3. Assaraf YG, Rothem L, Hooijberg JH, Stark M, Ifergan I, Kathmann I, Dijkmans BA, Peters GJ and Jansen G. (2003). J. Biol. Chem., 278, 6680-6686.
4. Bakos E, Evers R, Szakacs G, Tusnady GE, Welker E, Szabo K, de Haas M, van Deemter L, Borst P, Varadi A and Sarkadi B. (1998). J. Biol. Chem., 273, 32167-32175.
5. Bakos E, Hegedus T, Hollo Z, Welker E, Tusnady GE, Zaman GJ, Flens MJ, Varadi A and Sarkadi B. (1996). J. Biol. Chem., 271, 12322-12326.
6. Bankir L, Ahloulay M, Devreotes PN and Parent CA. (2002). Am. J. Physiol. Renal Physiol., 282, F376-92.
7. Bartosz G, Konig J, Keppler D and Hagmann W. (1998). Biol. Chem., 379, 1121-1126.
8. Belinsky MG, Bain LJ, Balsara BB, Testa JR and Kruh GD. (1998). J. Natl. Cancer Inst., 90, 1735-1741.
9. Belinsky MG, Chen ZS, Shchaveleva I, Zeng H and Kruh GD. (2002). Cancer Res., 62, 6172-6177.
10. Belinsky MG and Kruh GD. (1999). Br. J. Cancer, 80, 1342-1349.
11. Bera TK, Iavarone C, Kumar V, Lee S, Lee B and Pastan I. (2002). Proc. Natl. Acad. Sci. USA, 99, 6997-7002.
12. Bera TK, Lee S, Salvatore G, Lee B and Pastan IH. (2001). Mol. Med., 7, 509-516.
13. Bergen AA, Plomp AS, Schuurman EJ, Terry S, Breuning M, Dauwerse H, Swart J, Kool M, van Soest S, Baas F, ten Brink JB and de Jong PT. (2000). Nat. Genet., 25, 228-231.
14. Bodo A, Bakos E, Szeri F, Varadi A and Sarkadi B. (2003). J. Biol. Chem., 278, 23529-23537.
15. Breuninger LM, Paul S, Gaughan K, Miki T, Chan A, Aaronson SA and Kruh GD. (1995). Cancer Res., 55, 5342-5347.
16. Burger H, Foekens JA, Look MP, Meijer-van Gelder ME, Klijn JG, Wiemer EA, Stoter G and Nooter K. (2003). Clin. Cancer Res., 9, 827-836.
17. Chen Z-S, Furukawa T, Sumizawa T, Ono K, Ueda K, Seto K and Akiyama SI. (1999a). Mol. Pharmacol., 55, 921-928.
18. Chen Z-S, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M and Akiyama SI. (1999b). Mol. Pharmacol., 56, 1219-1228.
19. Chen Z-S, Lee K and Kruh GD. (2001). J. Biol. Chem., 276, 33747-33754.
20. Chen Z-S, Lee K, Walther S, Blanchard Raftogianis R, Kuwano M, Zeng H and Kruh GD. (2002). Cancer Res., 62, 3144-3150.
21. Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E and Kruh GD. (2003a). Mol. Pharmacol., 63, 351-358.
22. Chen Z-S, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD and Kruh GD. (2003b). Cancer Res., 63, 4048-4059.
23. Chu XY, Kato Y, Niinuma K, Sudo KI, Hakusui H and Sugiyama Y. (1997). J. Pharmacol. Exp. Ther., 281, 304-314.
24. Ciaccio PJ, Shen H, Kruh GD and Tew KD. (1996). Biochem. Biophys. Res. Commun., 222, 111-115.
25. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM and Deeley RG. (1992). Science, 258, 1650-1654.
26. Cole SP, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM and Deeley RG. (1994). Cancer Res., 54, 5902-5910.
27. Cui Y, Konig J, Buchholz JK, Spring H, Leier I and Keppler D. (1999). Mol. Pharmacol., 55, 929-937.
28. Daoud R, Desneves J, Deady LW, Tilley L, Scheper RJ, Gros P and Georges E. (2000a). Biochemistry, 39, 6094-6102.
29. Daoud R, Julien M, Gros P and Georges E. (2001). J. Biol. Chem., 276, 12324-12330.
30. Daoud R, Kast C, Gros P and Georges E. (2000b). Biochemistry, 39, 15344-15352.
31. Dietrich CG, de Waart DR, Ottenhoff R, Bootsma AH, van Gennip AH and Elferink RP. (2001). Carcinogenesis, 22, 805-811.
32. Donner MG and Keppler D. (2001). Hepatology, 34, 351-359.
33. Dubin IN and Johnson FB. (1954). Medicine, 33, 155-197.
34. Elferink RP, Ottenhoff R, Liefting W, de Haan J and Jansen PL. (1989). J. Clin. Invest., 84, 476-483.
35. Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J and Borst P. (2000). Br. J. Cancer, 83, 375-383.
36. Evers R, Zaman GJ, van Deemter L, Jansen H, Calafat J, Oomen LC, Oude Elferink RP, Borst P and Schinkel AH. (1996). J. Clin. Invest., 97, 1211-1218.
37. Fernandes DJ, Danks MK and Beck WT. (1990). Biochemistry, 29, 4235-4416.
38. Flens MJ, Zaman GJ, van der Valk P, Izquierdo MA, Schroeijers AB, Scheffer GL, van der Groep P, de Haas M, Meijer CJ and Scheper RJ. (1996). Am. J. Pathol., 148, 1237-1247.
39. Gao M, Yamazaki M, Loe DW, Westlake CJ, Grant CE, Cole SP and Deeley RG. (1998). J. Biol. Chem., 273, 10733-10740.
40. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF and Meier PJ. (1998). J. Biol. Chem., 273, 10046-10050.
41. Guo Y, Chen Z-S, Kotova E, Hoppper-Borge E and Kruh GD. (2003). J. Biol. Chem., 278, 29509-29514.
42. Gupta E, Safa AR, Wang X and Ratain MJ. (1996). Cancer Res., 56, 1309-1314.
43. Haimeur A, Deeley RG and Cole SP. (2002). J. Biol. Chem., 277, 41326-41333.
44. Harris MJ, Kuwano M, Webb M and Board PG. (2001). J. Biol. Chem., 276, 20876-20881.
45. Hegedus T, Sessler T, Scott R, Thelin W, Bakos E, Varadi A, Szabo K, Homolya L, Milgram SL and Sarkadi B. (2003). Biochem. Biophys. Res. Commun., 302, 454-461.
46. Hinoshita E, Uchiumi T, Taguchi K, Kinukawa N, Tsuneyoshi M, Maehara Y, Sugimachi K and Kuwano M. (2000). Clin. Cancer Res., 6, 2401-2407.
47. Hipfner DR, Almquist KC, Leslie EM, Gerlach JH, Grant CE, Deeley RG and Cole SP. (1997). J. Biol. Chem., 272, 23623-23630.
48. Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T and Sugiyama Y. (1998). Mol. Pharmacol., 53, 1068-1075.
49. Hirohashi T, Suzuki H and Sugiyama Y. (1999). J. Biol. Chem., 274, 15181-15185.
50. Hirohashi T, Suzuki H, Takikawa H and Sugiyama Y. (2000). J. Biol. Chem., 275, 2905-2910.
51. Hirrlinger J, Konig J, Keppler D, Lindenau J, Schulz JB and Dringen R. (2001). J. Neurochem., 76, 627-636.
52. Hooijberg JH, Broxterman HJ, Kool M, Assaraf YG, Peters GJ, Noordhuis P, Scheper RJ, Borst P, Pinedo HM and Jansen G. (1999). Cancer Res., 59, 2532-2535.
53. Hooijberg JH, Peters GJ, Assaraf YG, Kathmann I, Priest DG, Bunni MA, Veerman AJ, Scheffer GL, Kaspers GJ and Jansen G. (2003). Biochem. Pharmacol., 65, 765-771.
54. Hopper E, Belinsky MG, Zeng H, Tosolini A, Testa JR and Kruh GD. (2001). Cancer Lett., 162, 181-191.
55. Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, Sarkadi B and Varadi A. (2002). J. Biol. Chem., 277, 16860-16867.
56. Inokuchi A, Hinoshita E, Iwamoto Y, Kohno K, Kuwano M and Uchiumi T. (2001). J. Biol. Chem., 4, 4.
57. Ishikawa T. (1992). Trends Biochem. Sci., 17, 463-468.
58. Ishikawa T and Ali-Osman F. (1993). J. Biol. Chem., 268, 20116-20125.
59. Ito K, Oleschuk CJ, Westlake C, Vasa MZ, Deeley RG and Cole SP. (2001a). J. Biol. Chem., 276, 38108-38114.
60. Ito K, Olsen SL, Qiu W, Deeley RG and Cole SP. (2001b). J. Biol. Chem., 276, 15616-15624.
61. Ito K, Suzuki H and Sugiyama Y. (2001c). Mol. Pharmacol., 59, 1077-1085.
62. Ito K, Suzuki H and Sugiyama Y. (2001d). Am. J. Physiol. Gastrointest. Liver Physiol., 281, G1034-G1043.
63. Jansen PL, Peters WH and Lamers WH. (1985). Hepatology, 5, 573-579.
64. Jedlitschky G, Burchell B and Keppler D. (2000). J. Biol. Chem., 275, 30069-30074.
65. Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G and Keppler D. (1996). Cancer Res., 56, 988-994.
66. Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B and Keppler D. (1997). Biochem. J., 327 (Part 1), 305-310.
67. Johnson DR, Finch RA, Lin ZP, Zeiss CJ and Sartorelli AC. (2001). Cancer Res., 61, 1469-1476.
68. Kao H, Huans J and Chang M. (2002). Gene, 286, 299-306.
69. Kartenbeck J, Leuschner U, Mayer R and Keppler D. (1996). Hepatology, 23, 1061-1066.
70. Karwatsky J, Daoud R, Cai J, Gros P and Georges E. (2003). Biochemistry, 42, 3286-3294.
71. Kast C and Gros P. (1997). J. Biol. Chem., 272, 26479-26487.
72. Kawabe T, Chen Z-S, Wada M, Uchiumi T, Ono M, Akiyama S and Kuwano M. (1999). FEBS Lett., 456, 327-331.
73. Kitamura T, Jansen P, Hardenbrook C, Kamimoto Y, Gatmaitan Z and Arias IM. (1990). Proc. Natl. Acad. Sci. USA, 87, 3557-3561.
74. Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA and Sugiyama Y. (1998). FEBS Lett., 433, 149-152.
75. Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF and Knoll JH. (1999). Lab. Invest., 79, 1161-1170.
76. Koike K, Kawabe T, Tanaka T, Toh S, Uchiumi T, Wada M, Akiyama S, Ono M and Kuwano M. (1997). Cancer Res., 57, 5475-5479.
77. Konno T, Ebihara T, Hisaeda K, Uchiumi T, Nakamura T, Shirakusa T, Kuwano M and Wada M. (2003). J. Biol. Chem., 278, 22908-22917.
78. Kool M, van der Linden M, de Haas M, Baas F and Borst P. (1999a). Cancer Res., 59, 175-182.
79. Kool M, van der Linden M, de Haas M, Scheffer GL, de Vree JM, Smith AJ, Jansen G, Peters GJ, Ponne N, Scheper RJ, Elferink RP, Baas F and Borst P. (1999b). Proc. Natl. Acad. Sci. USA, 96, 6914-6919.
80. Krishnamachary N and Center MS. (1993). Cancer Res., 53, 3658-3661.
81. Kruh GD, Chan A, Myers K, Gaughan K, Miki T and Aaronson SA. (1994). Cancer Res., 54, 1649-1652.
82. Kruh GD, Gaughan KT, Godwin A and Chan A. (1995). J. Natl. Cancer Inst., 87, 1256-1258.
83. Kruh GD, Zeng H, Rea PA, Liu G, Chen Z-S, Lee K and Belinsky MG. (2001). J. Bioenerg. Biomembr., 33, 493-501.
84. Kuo MT, Bao JJ, Curley SA, Ikeguchi M, Johnston DA and Ishikawa T. (1996). Cancer Res., 56, 3642-3644.
85. Lai L and Tan TM. (2002). Biochem. J., 361, 497-503.
86. Le Saux O, Urban Z, Tschuch C, Csiszar K, Bacchelli B, Quaglino D, Pasquali-Ronchetti I, Pope FM, Richards A, Terry S, Bercovitch L, de Paepe A and Boyd CD. (2000). Nat. Genet., 25, 223-227.
87. Lee K, Belinsky MG, Bell DW, Testa JR and Kruh GD. (1998). Cancer Res., 58, 2741-2747.
88. Lee K, Klein-Szanto AJ and Kruh GD. (2000). J. Natl. Cancer Inst., 92, 1934-1940.
89. Legare D, Richard D, Mukhopadhyay R, Stierhof YD, Rosen BP, Haimeur A, Papadopoulou B and Ouellette M. (2001). J. Biol. Chem., 276, 26301-26307.
90. Leier I, Jedlitschky G, Buchholz U, Center M, Cole SP, Deeley RG and Keppler D. (1996a). Biochem. J., 314 (Part 2), 433-437.
91. Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG and Keppler D. (1994). J. Biol. Chem., 269, 27807-27810.
92. Leier I, Jedlitschky G, Buchler M, Buchholz U, Brom M and Keppler D. (1996b). Eur. J. Biochem., 242, 201-205.
93. Leslie EM, Deeley RG and Cole SP. (2003a). Drug Metab. Dispos., 31, 11-15.
94. Leslie EM, Ito K, Upadhyaya P, Hecht SS, Deeley RG and Cole SP. (2001). J. Biol. Chem., 276, 27846-27854.
95. Leslie EM, Letourneau IJ, Deeley RG and Cole SP. (2003b). Biochemistry, 42, 5214-5224.
96. Li ZS, Lu YP, Zhen RG, Szczypka M, Thiele DJ and Rea PA. (1997). Proc. Natl. Acad. Sci. USA, 94, 42-47.
97. Lin ZP, Johnson DR, Finch RA, Belinsky MG, Kruh GD and Sartorelli AC. (2002). Mol. Cancer Ther., 1, 1105-1114.
98. Loe DW, Almquist KC, Cole SP and Deeley RG. (1996a). J. Biol. Chem., 271, 9683-9689.
99. Loe DW, Almquist KC, Deeley RG and Cole SP. (1996b). J. Biol. Chem., 271, 9675-9682.
100. Loe DW, Deeley RG and Cole SP. (1998). Cancer Res., 58, 5130-5136.
101. Loe DW, Deeley RG and Cole SP. (2000). J. Pharmacol. Exp. Ther., 293, 530-538.
102. Lorico A, Bertola A, Baum C, Fodstad O and Rappa G. (2002). Biochem. Biophys. Res. Commun., 291, 617-622.
103. Lorico A, Rappa G, Finch RA, Yang D, Flavell RA and Sartorelli AC. (1997). Cancer Res., 57, 5238-5242.
104. Madon J, Hagenbuch B, Landmann L, Meier PJ and Stieger B. (2000). Mol. Pharmacol., 57, 634-641.
105. Manciu L, Chang XB, Buyse F, Hou YX, Gustot A, Riordan JR and Ruysschaert JM. (2003). J. Biol. Chem., 278, 3347-3356.
106. Mao Q, Qiu W, Weigl KE, Lander PA, Tabas LB, Shepard RL, Dantzig AH, Deeley RG and Cole SP. (2002). J. Biol. Chem., 277, 28690-28699.
107. Marquardt D, McCrone S and Center MS. (1990). Cancer Res., 50, 1426-1430.
108. Masuda M, I'izuka Y, Yamazaki M, Nishigaki R, Kato Y, Ni'inuma K, Suzuki H and Sugiyama Y. (1997). Cancer Res., 57, 3506-3510.
109. McAleer MA, Breen MA, White NL and Matthews N. (1999). J. Biol. Chem., 274, 23541-23548.
110. McGrath T and Center MS. (1987). Biochem. Biophys. Res. Commun., 145, 1171-1176.
111. McGrath T, Latoud C, Arnold ST, Safa AR, Felsted RL and Center MS. (1989). Biochem. Pharmacol., 38, 3611-3619.
112. Miller DS, Nobmann SN, Gutmann H, Toeroek M, Drewe J and Fricker G. (2000). Mol. Pharmacol., 58, 1357-1367.
113. Morikawa A, Goto Y, Suzuki H, Hirohashi T and Sugiyama Y. (2000). Pharm. Res., 17, 546-552.
114. Morrow CS, Smitherman PK, Diah SK, Schneider E and Townsend AJ. (1998). J. Biol. Chem., 273, 20114-20120.
115. Mottino AD, Hoffman T, Jennes L and Vore M. (2000). J. Pharmacol. Exp. Ther., 293, 717-723.
116. Moyer BD, Denton J, Karlson KH, Reynolds D, Wang S, Mickle JE, Milewski M, Cutting GR, Guggino WB, Li M and Stanton BA. (1999). J. Clin. Invest., 104, 1353-1361.
117. Nies AT, Konig J, Cui Y, Brom M, Spring H and Keppler D. (2002a). Eur. J. Biochem., 269, 1866-1876.
118. Nies AT, Konig J, Pfannschmidt M, Klar E, Hofmann WJ and Keppler D. (2001). Int. J. Cancer, 94, 492-499.
119. Nies AT, Spring H, Thon WF, Keppler D and Jedlitschky G. (2002b). J. Urol., 167, 2271-2275.
120. O'Brien M, Kruh GD and Tew KD. (2000). J. Pharmacol. Exp. Ther., 294, 480-487.
121. Ohishi Y, Oda Y, Uchiumi T, Kobayashi H, Hirakawa T, Miyamoto S, Kinukawa N, Nakano H, Kuwano M and Tsuneyoshi M. (2002). Clin. Cancer Res., 8, 3767-3775.
122. Paulusma CC, Bosma PJ, Zaman GJ, Bakker CT, Otter M, Scheffer GL, Scheper RJ, Borst P and Oude Elferink RP. (1996). Science, 271, 1126-1128.
123. Paumi CM, Ledford BG, Smitherman PK, Townsend AJ and Morrow CS. (2001). J. Biol. Chem., 276, 7952-7956.
124. Plasschaert SL, Vellenga E, de Bont ES, van der Kolk DM, Veerman AJ, Sluiter WJ, Daenen SM, de Vries EG and Kamps WA. (2003). Leukemia Lvmphoma, 44, 85-95.
125. Potschka H, Fedrowitz M and Loscher W. (2003). J. Pharmacol. Exp. Ther.
126. Qian YM, Grant CE, Westlake CJ, Zhang DW, Lander PA, Shepard RL, Dantzig AH, Cole SP and Deeley RG. (2002). J. Biol. Chem., 277, 35225-35231.
127. Qian YM, Song WC, Cui H, Cole SP and Deeley RG. (2001). J. Biol. Chem., 276, 6404-6411.
128. Randolph GJ. (2001). Semin. Immunol., 13, 267-274.
129. Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC and Piwnica-Worms D. (1999). Proc. Natl. Acad. Sci. USA, 96, 3900-3905.
130. Rappa G, Lorico A, Flavell RA and Sartorelli AC. (1997). Cancer Res., 57, 5232-5237.
131. Ren XQ, Furukawa T, Aoki S, Nakajima T, Sumizawa T, Haraguchi M, Chen ZS, Kobayashi M and Akiyama S. (2001). J. Biol. Chem., 276, 23197-23206.
132. Ren XQ, Furukawa T, Aoki S, Sumizawa T, Haraguchi M, Nakajima Y, Ikeda R, Kobayashi M and Akiyama S. (2002). Biochemistry, 41, 14132-14140.
133. Ringpfeil F, Lebwohl MG, Christiano AM and Uitto J. (2000). Proc. Natl. Acad. Sci. USA, 97, 6001-6006.
134. Robbiani DF, Finch RA, Jager D, Muller WA, Sartorelli AC and Randolph GJ. (2000). Cell, 103, 757-768.
135. Robbins BL, Connelly MC, Marshall DR, Srinivas RV and Fridland A. (1995). Mol. Pharmacol., 47, 391-397.
136. Rosenberg MF, Mao Q, Holzenburg A, Ford RC, Deeley RG and Cole SP. (2001). J. Biol. Chem., 276, 16076-16082.
137. Rost D, Mahner S, Sugiyama Y and Stremmel W. (2002). Am. J. Physiol. Gastrointest. Liver Physiol., 282, G720-6.
138. Ryu S, Kawabe T, Nada S and Yamaguchi A. (2000). J. Biol. Chem., 275, 39617-39624.
139. Sakamoto H, Hara H, Hirano K and Adachi T. (1999). Cancer Lett., 135, 113-119.
140. Sanghani PC and Moran RG. (2000). Protein Expres. Purif., 18, 36-45.
141. Sauerbrey A, Voigt A, Wittig S, Hafer R and Zintl F. (2002). Leukemia Lymphoma, 43, 875-879.
142. Schaub TP, Kartenbeck J, Konig J, Vogel O, Witzgall R, Kriz W and Keppler D. (1997). J. Am. Soc. Nephrol., 8, 1213-1221.
143. Scheffer GL, Hu X, Pijnenborg AC, Wijnholds J, Bergen AA and Scheper RJ. (2002a). Lab. Invest., 82, 515-518.
144. Scheffer GL, Kool M, de Haas M, de Vree JM, Pijnenborg AC, Bosman DK, Elferink RP, van der Valk P, Borst P and Scheper RJ. (2002b). Lab. Invest., 82, 193-201.
145. Schneider E, Yamazaki H, Sinha BK and Cowan KH. (1995). Br. J. Cancer, 71, 738-743.
146. Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A and Fridland A. (1999). Nat. Med., 5, 1048-1051.
147. Schultz MJ, Wijnholds J, Peppelenbosch MP, Vervoordeldonk MJ, Speelman P, van Deventer SJ, Borst P and van der Poll T. (2001). J. Immunol., 166, 4059-4064.
148. Soderling SH and Beavo JA. (2000). Curr. Opin. Cell Biol., 12, 174-179.
149. Soroka CJ, Lee JM, Azzaroli F and Boyer JL. (2001). Hepatology, 33, 783-791.
150. St-Pierre MV, Serrano MA, Macias RI, Dubs U, Hoechli M, Lauper U, Meier PJ and Marin JJ. (2000). Am. J. Physiol. Regul. Integr. Comp. Physiol., 279, R1495-503.
151. Steinbach D, Lengemann J, Voigt A, Hermann J, Zintl F and Sauerbrey A. (2003). Clin. Cancer Res., 9, 1083-1086.
152. Suzuki H and Sugiyama Y. (2002). Adv. Drug Deliv. Rev., 54, 1311-1331.
153. Taguchi Y, Yoshida A, Takada Y, Komano T and Ueda K. (1997). FEBS Lett., 401, 11-14.
154. Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Ptacek LJ, Rosier M, Dean M and Allikmets R. (2001). Gene, 273, 89-96.
155. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S and Kuwano M. (1996). Cancer Res., 56, 4124-4129.
156. Uchiumi T, Hinoshita E, Haga S, Nakamura T, Tanaka T, Toh S, Furukawa M, Kawabe T, Wada M, Kagotani K, Okumura K, Kohno K, Akiyama S and Kuwano M. (1998). Biochem. Biophys. Res. Commun., 252, 103-110.
157. Uitto J, Pulkkinen L and Ringpfeil F. (2001). Trends Mol. Med., 7, 13-17.
158. Van Aubel RA, Koenderink JB, Peters JG, Van Os CH and Russel FG. (1999). Mol. Pharmacol., 56, 714-719.
159. van Aubel RA, Smeets PH, Peters JG, Bindels RJ and Russel FG. (2002). J. Am. Soc. Nephrol., 13, 595-603.
160. van den Heuvel-Eibrink MM, Wiemer EA, Prins A, Meijerink JP, Vossebeld PJ, van der Holt B, Pieters R and Sonneveld P. (2002). Leukemia, 16, 833-839.
161. Vernhet L, Allain N, Payen L, Anger JP, Guillouzo A and Fardel O. (2001). Biochem. Pharmacol., 61, 1387-1391.
162. Vernhet L, Courtois A, Allain N, Payen L, Anger JP, Guillouzo A and Fardel O. (1999). FEBS Lett., 443, 321-325.
163. Versantvoort CH, Broxterman HJ, Bagrij T, Scheper RJ and Twentyman PR. (1995). Br. J. Cancer, 72, 82-89.
164. Volk EL, Farley KM, Wu Y, Li F, Robey RW and Schneider E. (2002). Cancer Res., 62, 5035-5040.
165. Volk EL, Rohde K, Rhee M, McGuire JJ, Doyle LA, Ross DD and Schneider E. (2000). Cancer Res., 60, 3514-3521.
166. Wielinga PR, Reid G, Challa EE, van der Heijden I, van Deemter L, de Haas M, Mol C, Kuil AJ, Groeneveld E, Schuetz JD, Brouwer C, De Abreu RA, Wijnholds J, Beijnen JH and Borst P. (2002). Mol. Pharmacol., 62, 1321-1331.
167. Wielinga PR, Van Der Heijden I, Reid G, Beijnen JH, Wijnholds J and Borst P. (2003). J. Biol. Chem., 278, 17664-17671.
168. Wijnholds J, deLange EC, Scheffer GL, van den Berg DJ, Mol CA, van der Valk M, Schinkel AH, Scheper RJ, Breimer DD and Borst P. (2000a). J. Clin. Invest., 105, 279-285.
169. Wijnholds J, Evers R, van Leusden MR, Mol CA, Zaman GJ, Mayer U, Beijnen JH, van der Valk M, Krimpenfort P and Borst P. (1997). Nat. Med., 3, 1275-1279.
170. Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J and Borst P. (2000b). Proc. Natl. Acad. Sci. USA, 97, 7476-7481.
171. Yabuuchi H, Shimizu H, Takayanagi S and Ishikawa T. (2001). Biochem. Biophys. Res. Commun., 288, 933-939.
172. Yang Y, Chen Q and Zhang JT. (2002). J. Biol. Chem., 277, 44268-44277.
173. Zaman GJ, Flens MJ, van Leusden MR, de Haas M, Mulder HS, Lankelma J, Pinedo HM, Scheper RJ, Baas F, Broxterman HJ and Borst P. (1994). Proc. Natl. Acad. Sci. USA, 91, 8822-8826.
174. Zaman GJ, Lankelma J, van Tellingen O, Beijnen J, Dekker H, Paulusma C, Oude Elferink RP, Baas F and Borst P. (1995). Proc. Natl. Acad. Sci. USA, 92, 7690-7694.
175. Zelcer N, Huisman MT, Reid G, Wielinga PR, Breedveld P, Kuil A, Knipscheer P, Schellens JH, Schinkel AH and Borst P. (2003a). J. Biol. Chem., 278, 23538-23544.
176. Zelcer N, Reid G, Wielinga P, Kuil A, Van Der Heijden I, Schuetz JD and Borst P. (2003b). Biochem. J., 371, 361-367.
177. Zelcer N, Saeki T, Reid G, Beijnen JH and Borst P. (2001). J. Biol. Chem., 276, 46400-46407.
178. Zeng H, Bain LJ, Belinsky MG and Kruh GD. (1999). Cancer Res., 59, 5964-5967.
179. Zeng H, Chen Z-S, Belinsky MG, Rea PA and Kruh GD. (2001). Cancer Res., 61, 7225-7232.
180. Zeng H, Liu G, Rea PA and Kruh GD. (2000). Cancer Res., 60, 4779-4784.
181. Zhang DW, Cole SP and Deeley RG. (2001a). J. Biol. Chem., 276, 34966-34974.
182. Zhang DW, Cole SP and Deeley RG. (2001b). J. Biol. Chem., 276, 13231-13239.
183. Zhang DW, Cole SP and Deeley RG. (2002). J. Biol. Chem., 277, 20934-20941.
184. Zurita AJ, Diestra JE, Condom E, Garcia Del Muro X, Scheffer GL, Scheper RJ, Perez J, Germa-Lluch JR and Izquierdo MA. (2003). Br. J. Cancer, 88, 879-886.