Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin

Journal of Pharmacy and Pharmacology

Volumn 56, Issue 1, 2004, Pages 123-128

  Wang, Er Jia ^a   Barecki Roach, Mary ^a   Johnson, William W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; CYCLOSPORIN A; DAUNORUBICIN; GLYCOPROTEIN P; GRAMICIDIN; HYPERFORIN; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; PSEUDOHYPERICIN; RHODAMINE 123; VALSPODAR; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG PROTEIN BINDING; FLUORESCENCE; HUMAN; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS;

ANIMALS; BICYCLO COMPOUNDS; FLOW CYTOMETRY; GENES, MDR; HERB-DRUG INTERACTIONS; HUMANS; HYPERICUM; MICE; NIH 3T3 CELLS; P-GLYCOPROTEIN; PERYLENE; PHLOROGLUCINOL; TERPENES;

EID: 1042304296     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357022395     Document Type: Article

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