A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells

Japanese Journal of Cancer Research

Volumn 92, Issue 7, 2001, Pages 785-792

  Nokihara, Hiroshi ^a   Yano, Seiji ^a   Nishioka, Yasuhiko ^a   Hanibuchi, Masaki ^a   Higasida, Tsuyoshi ^a   Tsuruo, Takashi ^b   Sone, Saburo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Metastasis; MS 209; Multidrug resistance; Small cell lung cancer

Indexed keywords

5 [3 (4 DIPHENYLACETYL 1 PIPERAZINYL) 2 HYDROXYPROPOXY]QUINOLINE; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; QUINOLONE DERIVATIVE; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER THERAPY; CHEMOSENSITIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG RESISTANCE; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INJECTION; KIDNEY METASTASIS; LIVER METASTASIS; LUNG SMALL CELL CANCER; LYMPH NODE METASTASIS; MALE; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SMALL CELL; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, SCID; NEOPLASM METASTASIS; P-GLYCOPROTEIN; QUINOLINES; VINCRISTINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0034879931     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01162.x     Document Type: Article

References (24)

1. Cancer statistics, 1999
2. Mechanisms of multidrug resistance and implications for therapy
3. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
4. The drug resistance-related protein LRP is the human major vault protein
5. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction
6. Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas
7. Increased accumulation of vincristine and adriamycin in drug-resistant tumor cells following incubation with calcium antagonists and calmodulin inhibitors
8. Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro
9. Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC-833, a nonimmunosuppressive cyclosporin derivative
10. Relationship between multidrug resistant gene expression and multidrug resistant-reversing effect of MS-209 in various tumor cells
11. Reversal of multidrug resistance by a novel quinoline derivative, MS-209
12. Recovery of drug sensitivity by MS-209, a new multidrug resistance-reversing agent, on acute myelogenous leukemic blasts and K562 cells resistant to adriamycin cell line
13. Potentiation of the antitumor activity by a novel quinoline compound. MS-209, in multidrug-resistant solid tumor cell lines
14. Circumvention of multidrug resistance by a quinoline derivative, MS-209, in multidrug-resistant human small-cell lung cancer cells and its synergistic interaction with cyclosporin A or verapamil
15. Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies
16. Antitumor activity of platinum analogs against human lung cancer cell lines and tumor specimens
17. Monocyte chemoattractant protein-1 gene modification of multidrug-resistant human lung cancer enhances antimetastatic effect of therapy with anti-P-glycoprotein antibody in SCID mice
18. Rapid colorimetric assay for cell viability: Application to the quantitation of cytotoxic and growth-inhibitory lymphokines
19. Novel metastasis model of human lung cancer in SCID mice depleted of NK cells
20. Therapeutic efficacy of mouse-human chimeric anti-ganglioside GM2 monoclonal antibody against multiple organ micrometastases of human lung cancer in NK cell-depleted SCID mice
21. Macrophage colony-stimulating factor gene transduction into human lung cancer cells differentially regulates metastasis formations in various organ microenvironments of natural killer cell-depleted SCID mice
22. Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells
23. Differences in drug sensitivity among tumor cells from parental tumors, selected variants, and spontaneous metastases
24. Combined therapy with anti-P-glycoprotein antibody and macrophage colony-stimulating factor gene transduction for multiorgan metastases of multidrug-resistant human small cell lung cancer in NK cell-depleted SCID mice