메뉴 건너뛰기




Volumn 6, Issue 4, 2001, Pages 206-212

Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYL BETA GLUCURONIDE; 2,4 DICHLOROPHENOXYACETIC ACID; 4 AMINOHIPPURIC ACID; 5 AMINO 7 (7 AMINO 5 AZASPIRO[2.4]HEPT 5 YL) 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHYL 4 OXO 3 QUINOLINECARBOXYLIC ACID; ASIMADOLINE; COLCHICINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYCLOPEPTIDE; CYCLOSPORIN A; DEXAMETHASONE; DIDANOSINE; DIGOXIN; DOXORUBICIN; GLYCOPROTEIN P; GREPAFLOXACIN; INDINAVIR; IVERMECTIN; LOPERAMIDE; MORPHINE; ONDANSETRON; PENICILLIN G; PROGESTERONE; QUINIDINE; SPARFLOXACIN; TACROLIMUS; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; VALSPODAR; VERAPAMIL; VINCRISTINE; ZIDOVUDINE;

EID: 0035254189     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01643-3     Document Type: Review
Times cited : (88)

References (46)
  • 2
    • 0029056457 scopus 로고
    • In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 1541-1544
    • Ohnishi, T.1
  • 3
    • 0027998226 scopus 로고
    • In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1989-1992
    • Sakata, A.1
  • 5
    • 0026760889 scopus 로고
    • P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells.
    • (1992) Life Sci. , vol.51 , pp. 1427-1437
    • Tsuji, A.1
  • 6
    • 0028892249 scopus 로고
    • Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain epididymal fat pad and from aorta.
    • (1995) FEBS Lett. , vol.374 , pp. 179-183
    • Barrand, M.A.1
  • 7
    • 0026669192 scopus 로고
    • Functional involvement of P-glycoprotein in blood-brain barrier.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20383-20391
    • Tatsuta, T.1
  • 8
    • 0027956555 scopus 로고
    • Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein.
    • (1994) Biochim. Biophys. Acta , vol.1222 , pp. 400-404
    • Shirai, A.1
  • 10
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1
  • 11
    • 0030963724 scopus 로고    scopus 로고
    • Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism.
    • (1997) Toxicol. Appl. Pharmacol. , vol.146 , pp. 88-94
    • Umbenhauer, D.R.1
  • 14
    • 0031757312 scopus 로고    scopus 로고
    • BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.
    • (1998) Pharm. Res. , vol.15 , pp. 1657-1665
    • De Lange, E.C.1
  • 17
    • 0031874816 scopus 로고    scopus 로고
    • Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography.
    • (1998) Br. J. Pharmacol. , vol.124 , pp. 1413-1418
    • Hendrikse, N.H.1
  • 18
    • 0029892497 scopus 로고    scopus 로고
    • P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2517-2524
    • Schinkel, A.H.1
  • 19
    • 0025980945 scopus 로고
    • In vivo study of the elimination from rat brain of an intracerebrally formed xenobiotic metabolite 1-naphthyl-(-d-glucuronide.
    • (1991) J. Neurochem. , vol.56 , pp. 1163-1168
    • Leininger, B.1
  • 20
    • 0027956723 scopus 로고
    • Saturable efflux of the peptides RC160 and Tyr-MIF-1 by different parts of the blood-brain barrier.
    • (1994) Brain Res. Bull. , vol.35 , pp. 179-182
    • Banks, W.A.1
  • 21
    • 0031456590 scopus 로고    scopus 로고
    • Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method.
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , pp. 1018-1025
    • Kakee, A.1
  • 22
    • 0030977086 scopus 로고    scopus 로고
    • In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2′3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 369-375
    • Takasawa, K.1
  • 24
    • 0032819955 scopus 로고    scopus 로고
    • Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver.
    • (1999) Gastroenterology , vol.117 , pp. 688-695
    • Reichel, C.1
  • 25
    • 0031809205 scopus 로고    scopus 로고
    • Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 1260-1265
    • Kusuhara, H.1
  • 26
    • 0032934648 scopus 로고    scopus 로고
    • High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 198-203
    • Homma, M.1
  • 27
    • 0343554785 scopus 로고    scopus 로고
    • Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the CNS.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 257-285
    • Suzuki, H.1
  • 28
    • 0033956508 scopus 로고    scopus 로고
    • Drug transport in the mammalian CNS: multiple complex systems. A critical analysis and commentary.
    • (2000) Pharmacology , vol.60 , pp. 58-73
    • Spector, R.1
  • 29
    • 0032967070 scopus 로고    scopus 로고
    • Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 289-294
    • Nishino, J.1
  • 30
    • 0033585013 scopus 로고    scopus 로고
    • Mechanism of organic anion transport across the apical membrane of choroid plexus.
    • (1999) J. Biol. Chem. , vol.274 , pp. 33382-33387
    • Pritchard, J.B.1
  • 31
    • 20244386956 scopus 로고    scopus 로고
    • Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.
    • (1997) Nat. Med. , vol.3 , pp. 1275-1279
    • Wijnholds, J.1
  • 32
    • 0033975098 scopus 로고    scopus 로고
    • Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.
    • (2000) J. Clin. Invest. , vol.105 , pp. 279-285
    • Wijnholds, J.1
  • 33
    • 0029922224 scopus 로고    scopus 로고
    • Characterization of the transport properties of a quinolone antibiotic, fleroxacin in rat choroid plexus.
    • (1996) Pharm. Res. , vol.13 , pp. 523-527
    • Ooie, T.1
  • 34
    • 0024409224 scopus 로고
    • Transport of cefodizime, a novel third generation cephalosporin antibiotic in isolated rat choroid plexus.
    • (1989) J. Pharmacol. Exp. Ther. , vol.250 , pp. 324-328
    • Nohjoh, T.1
  • 35
    • 0032496763 scopus 로고    scopus 로고
    • Active transport properties of porcine choroid plexus cells in culture.
    • (1998) Brain Res. , vol.795 , pp. 247-256
    • Hakvoort, A.1
  • 36
    • 0020529746 scopus 로고
    • Saturable accumulation of the anionic herbicide, 2,4-dichlorophenoxyacetic acid (2,4D) by rabbit choroid plexus: early developmental origin and interaction with salicylates.
    • (1983) J. Pharmacol. Exp. Ther. , vol.225 , pp. 699-704
    • Kim, C.S.1
  • 37
    • 0027976519 scopus 로고
    • Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.
    • (1994) J. Neurochem. , vol.62 , pp. 1089-1096
    • Ghersi-Egea, J.F.1
  • 38
  • 39
    • 0032960014 scopus 로고    scopus 로고
    • Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side effects of asimadoline a peripherally acting analgesic drug.
    • (1999) Br. J. Pharmacol. , vol.127 , pp. 43-50
    • Jonker, J.W.1
  • 40
    • 0028825399 scopus 로고
    • Absence of the Mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone digoxin and cyclosporin A.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1
  • 42
    • 0032807119 scopus 로고    scopus 로고
    • P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in Mdr1 knockout mice.
    • (1999) Pharm. Res. , vol.16 , pp. 1213-1218
    • Yokogawa, K.1
  • 43
    • 0033815392 scopus 로고    scopus 로고
    • Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 146-152
    • Tamai, I.1
  • 44
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
    • (1998) J. Clin. Invest. , vol.101 , pp. 289-294
    • Kim, R.B.1
  • 46
    • 0031834184 scopus 로고    scopus 로고
    • Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent in mice.
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 438-443
    • Desrayaud, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.