-
2
-
-
0029056457
-
In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier.
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 1541-1544
-
-
Ohnishi, T.1
-
3
-
-
0027998226
-
In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1989-1992
-
-
Sakata, A.1
-
5
-
-
0026760889
-
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells.
-
(1992)
Life Sci.
, vol.51
, pp. 1427-1437
-
-
Tsuji, A.1
-
6
-
-
0028892249
-
Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain epididymal fat pad and from aorta.
-
(1995)
FEBS Lett.
, vol.374
, pp. 179-183
-
-
Barrand, M.A.1
-
7
-
-
0026669192
-
Functional involvement of P-glycoprotein in blood-brain barrier.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 20383-20391
-
-
Tatsuta, T.1
-
8
-
-
0027956555
-
Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein.
-
(1994)
Biochim. Biophys. Acta
, vol.1222
, pp. 400-404
-
-
Shirai, A.1
-
10
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
-
11
-
-
0030963724
-
Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism.
-
(1997)
Toxicol. Appl. Pharmacol.
, vol.146
, pp. 88-94
-
-
Umbenhauer, D.R.1
-
14
-
-
0031757312
-
BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.
-
(1998)
Pharm. Res.
, vol.15
, pp. 1657-1665
-
-
De Lange, E.C.1
-
17
-
-
0031874816
-
Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography.
-
(1998)
Br. J. Pharmacol.
, vol.124
, pp. 1413-1418
-
-
Hendrikse, N.H.1
-
18
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
-
19
-
-
0025980945
-
In vivo study of the elimination from rat brain of an intracerebrally formed xenobiotic metabolite 1-naphthyl-(-d-glucuronide.
-
(1991)
J. Neurochem.
, vol.56
, pp. 1163-1168
-
-
Leininger, B.1
-
20
-
-
0027956723
-
Saturable efflux of the peptides RC160 and Tyr-MIF-1 by different parts of the blood-brain barrier.
-
(1994)
Brain Res. Bull.
, vol.35
, pp. 179-182
-
-
Banks, W.A.1
-
21
-
-
0031456590
-
Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 1018-1025
-
-
Kakee, A.1
-
22
-
-
0030977086
-
In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2′3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.281
, pp. 369-375
-
-
Takasawa, K.1
-
24
-
-
0032819955
-
Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver.
-
(1999)
Gastroenterology
, vol.117
, pp. 688-695
-
-
Reichel, C.1
-
25
-
-
0031809205
-
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.285
, pp. 1260-1265
-
-
Kusuhara, H.1
-
26
-
-
0032934648
-
High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.288
, pp. 198-203
-
-
Homma, M.1
-
27
-
-
0343554785
-
Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the CNS.
-
(1997)
Adv. Drug Deliv. Rev.
, vol.25
, pp. 257-285
-
-
Suzuki, H.1
-
28
-
-
0033956508
-
Drug transport in the mammalian CNS: multiple complex systems. A critical analysis and commentary.
-
(2000)
Pharmacology
, vol.60
, pp. 58-73
-
-
Spector, R.1
-
29
-
-
0032967070
-
Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.290
, pp. 289-294
-
-
Nishino, J.1
-
30
-
-
0033585013
-
Mechanism of organic anion transport across the apical membrane of choroid plexus.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33382-33387
-
-
Pritchard, J.B.1
-
31
-
-
20244386956
-
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.
-
(1997)
Nat. Med.
, vol.3
, pp. 1275-1279
-
-
Wijnholds, J.1
-
32
-
-
0033975098
-
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 279-285
-
-
Wijnholds, J.1
-
33
-
-
0029922224
-
Characterization of the transport properties of a quinolone antibiotic, fleroxacin in rat choroid plexus.
-
(1996)
Pharm. Res.
, vol.13
, pp. 523-527
-
-
Ooie, T.1
-
34
-
-
0024409224
-
Transport of cefodizime, a novel third generation cephalosporin antibiotic in isolated rat choroid plexus.
-
(1989)
J. Pharmacol. Exp. Ther.
, vol.250
, pp. 324-328
-
-
Nohjoh, T.1
-
35
-
-
0032496763
-
Active transport properties of porcine choroid plexus cells in culture.
-
(1998)
Brain Res.
, vol.795
, pp. 247-256
-
-
Hakvoort, A.1
-
36
-
-
0020529746
-
Saturable accumulation of the anionic herbicide, 2,4-dichlorophenoxyacetic acid (2,4D) by rabbit choroid plexus: early developmental origin and interaction with salicylates.
-
(1983)
J. Pharmacol. Exp. Ther.
, vol.225
, pp. 699-704
-
-
Kim, C.S.1
-
37
-
-
0027976519
-
Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.
-
(1994)
J. Neurochem.
, vol.62
, pp. 1089-1096
-
-
Ghersi-Egea, J.F.1
-
39
-
-
0032960014
-
Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side effects of asimadoline a peripherally acting analgesic drug.
-
(1999)
Br. J. Pharmacol.
, vol.127
, pp. 43-50
-
-
Jonker, J.W.1
-
40
-
-
0028825399
-
Absence of the Mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone digoxin and cyclosporin A.
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 1698-1705
-
-
Schinkel, A.H.1
-
42
-
-
0032807119
-
P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in Mdr1 knockout mice.
-
(1999)
Pharm. Res.
, vol.16
, pp. 1213-1218
-
-
Yokogawa, K.1
-
43
-
-
0033815392
-
Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 146-152
-
-
Tamai, I.1
-
44
-
-
0032518290
-
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 289-294
-
-
Kim, R.B.1
-
46
-
-
0031834184
-
Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent in mice.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.285
, pp. 438-443
-
-
Desrayaud, S.1
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