Up-regulation of transporters of the MRP family by drugs and toxins

Toxicology Letters

Volumn 120, Issue 1-3, 2001, Pages 51-57

  Schrenk, Dieter ^a   Baus, Petra R ^a   Ermel, Nadine ^a   Klein, Christopher ^a   Vorderstemann, Birgit ^a   Kauffmann, Hans Martin ^a  

^a University of Kaiserslautern ^*  (Germany)

Author keywords

Gene expression; Induction by drugs and toxins; Multidrug resistance proteins

Indexed keywords

CISPLATIN; HYDROQUINONE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; N (2 FLUORENYL)ACETAMIDE; PHENOBARBITAL; RIFAMPICIN; TERT BUTYLHYDROQUINONE; VINBLASTINE;

CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ANIMALS; ANION TRANSPORT PROTEINS; ATP-BINDING CASSETTE TRANSPORTERS; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; TOXINS, BIOLOGICAL; UP-REGULATION;

EID: 0035977844     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00306-X     Document Type: Article

References (28)

1. Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells
2. The multidrug resistance protein family
3. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
5. Various rat tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
6. The effect of rifampin treatment on intestinal expression of human MRP transporters
7. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
8. Structural, mechanistic and clinical aspects of MRP1
9. Regulation of cytochrome P450 (CYP) genes by nuclear receptors
10. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
11. Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells
12. The multidrug resistance protein 5 (MRP5) functions as an ATP-dependent export pump for cyclic nucleotides
13. Sequence analysis and functional characterization of the 5′-flanking region of the rat 'multidrug resistance protein 2' (MRP2) gene
14. Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in hepatocytes
15. Induction of hepatic MRP2 (cMrp/cMoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen
16. DNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
17. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
18. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
19. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated resistance
20. Analysis of Expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
21. Increased expression of the MRP5 gene is associated with exposure to platinium drugs in lung cancer
22. Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells
23. Clinical importance of hepatic cytochrome P450 in drug metabolism
24. Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter
25. Characterization of the 5′-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 3 (MRP3) gene
26. Update on rifampin drug interactions, III
27. ARE- and TRE-mediated regulation of gene expression. Response to xenobiotics and antioxidants
28. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress