Effect of Cycloartanes on Reversal of Multidrug Resistance and Apoptosis Induction on Mouse Lymphoma Cells

Anticancer Research

Volumn 24, Issue 2 B, 2004, Pages 859-864

  Madureira, Ana Margarida ^a   Spengler, Gabriella ^b   Molnár, Annamária ^b   Varga, Andreas ^c   Molnár, Joseph ^b   Abreu, Pedro M ^d   Ferreira, Maria José U ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF SZEGED   (Hungary)

^c HUMBOLDT UNIVERSITY   (Germany)

^d DEPARTAMENTO DE QUÍMICA   (Portugal)

Author keywords

Apoptosis induction; Cycloartane triterpenes; Euphorbia; Mouse lymphoma cell line; Multidrug resistance

Indexed keywords

ABC TRANSPORTER; CYCLOARTAN 23 ENE 3BETA,25 DIOL; CYCLOARTANE 3BETA,24,25 TRIOL; CYCLOARTANE DERIVATIVE; EUPHORBIA EXTRACT; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROPIDIUM IODIDE; RHODAMINE 123; TRIHEXYPHENIDYL; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG ISOLATION; EUPHORBIA; FLOW CYTOMETRY; GENETIC TRANSFECTION; LYMPHOMA CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; EUPHORBIA; LYMPHOMA, T-CELL; MICE; PLANT EXTRACTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 2442443147     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Kim SE, Hong YS, Kim YC and Lee JJ: Mode of action of torilin in multidrug-resistance cancer cell lines. Planta Med 64: 335-338, 1998.
2. Wiese M and Pajeva IK: Structure-activity relationships of multidrug resistance reversers. Curr Med Chem 8: 685-713, 2001.
3. Wesolowska O, Molnár J, Motohashi N and Michalak K: Inhibition of P-glycoprotein transport function by N-acylphenothiazines. Anticancer Res 22: 2863-2868, 2002.
4. Tolomeo M and Simoni D: Drug resistance and apoptosis in cancer treatment: development of new apoptosis-inducing agents active in drug resistant malignancies. Curr Med Chem 2: 387-401, 2002.
5. Hartwell JL: Plants used against cancer. A survey. Lloydia 62: 153-205, 1969.
6. Hohmann J, Molnár J, Rédei D, Evanics F, Forgo P, Kálmán A, Argay G and Szabó P: Discovery and biological evaluation of a new family of potent modulators of multidrug resistance: reversal of multidrug resistance of mouse lymphoma cells by new natural jatrophane diterpenoids isolated from Euphorbia species. J Med Chem 45: 2425-2431, 2002.
7. Appendino G, Porta CD, Conseil G, Sterner O, Mercalli E, Dumontet C and Pietro AD: A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris). J Nat Prod 66: 140-142, 2003.
8. Valente C, Ferreira MJU, Abreu PM, Gyémánt N, Ugocsai K, Hohmann J and Molnár J: Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells. Planta Med 70: 81-88, 2004.
9. Kim HJ, Le QK, Lee MH, Kim YH, Bae K and Lee IS: A cytotoxic secocycloartenoid from Abies koreana. Arch Pharm Res 24: 527-31, 2001.
10. Tanaka R, Kinouchi Y, Tokuda H, Nishino H and Matsunaga S: Bioactive triterpenoids from steam bark of Picea glehni. Planta Med 66: 630-634, 2000.
11. Mohamad K, Martin MT, Leroy E, Tempête T, Sévenet T, Awang K and Païs M: Argenteanones C-E and argenteanones B-E, cytotoxic cycloartanes from Agaia argentea. J Nat Prod 60: 81-85, 1997.
12. Banskota AH, Tezuka Y, Phung LK, Tran KQ, Saiki I, Miwa Y, Taga T and Kadota S: Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare. Bioorg Med Chem Lett 8: 3519-3524, 1998.
13. Omobuwajo OR, Martin MT, Perromat G, Sévenet T, Awang K and Païs M: Cytotoxic cycloartanes from Aglaia argentea. Phytochemistry 41: 1325-1328, 1996.
14. Banskota AH, Tezuka Y, Tran KQ, Tanaka K, Saiki I and Kadota S: Methyl quadrangularates A-D and related triterpenes from Combretum quadrangulare. Chem Pharm Bull 48: 496-504, 2000.
15. Smith-Kielland I, Dornish JM, Malterud KE, Hvistendahl G, Rømming C, Bøockman OC, Kolsaker P, Stenstrøm and Nordal A: Cytotoxic triterpenoids from the leaves of Euphorbia pulcherrima. Planta Med 62: 322-325, 1996.
16. Öksüz S, Shieh HL, Pezzuto JM, Özhatay N and Cordell GA: Biologically active compounds from Euphorbiaceae; Part 1. Triterpenoids of Euphorbia nicaeensis subsp. glareosa. Planta Med 59: 472-473, 1993.
17. Ferreira MJU, Madureira AM and Ascenso JR: A tetracyclic diterpene and triterpenes from Euphorbia segetalis. Phytochemistry 49: 179-183,1998.
18. Madureira AM, Ascenso JR, Valdeira L, Duarte A, Frade JP, Freitas G and Ferreira MJU: Evaluation of the antiviral and antimicrobial activities of triterpenes isolated from Euphorbia segetalis. Nat Prod Res 17: 375-380, 2003.
19. Motohashi N, Kawase M, Kasihara T, Hever A, Nagy S, Tanaka M and Molnár J: Synthesis and antitumor activity of 1-(2-chlorethyl)-3-(2-substituted-10H-phenothiazine-10-yl)-alkylureas as potential anticancer agents. Anticancer Res 16: 2525-2532, 1996.
20. Cornwell MM, Pastan I and Gottesmann MM: Certain calcium channel blockers bind specifically to multidrug-resistance human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 262: 2166-2170, 1987.
21. Weaver JL, Szabo G, Pine PS, Gottesman MM, Goldenberg S and Aszalos A: The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multidrug transporter. Int J Cancer 54: 456-61, 1993.
22. Kessel D: Explorating multidrug resistance using Rhodamine 123. Cancer Commun 1: 145-149, 1989.
23. Koopmann G, Rentelinger CP, Kuijten Ga, Koehnen RM, Pals ST and Van OMH: Annexin V flow cytometric detection of phosphatidyl-serine expression on B cells undergoing apoptosis. Blood 84: 1115-1120, 1994.
24. Fu LW, Deng ZA, Pan QC and Fan W: Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Anticancer Res 21: 2273-2280, 2001.
25. Hichman JA: Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11: 121-139, 1992.
26. 10 P was estimated by using JME. Molecular Editor (http://www.molinspiration.com/jme).
27. Hendrich AB, Wesolowska O, Motohashi N, Molnár J and Michalak K: New phenothiazine-type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency. Biochem Bioph Res Co 304: 260-265, 2003.