Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 20, 1997, Pages 10594-10599

  Dey, Saibal ^a   Ramachandra, Muralidhara ^a,b   Pastan, Ira ^a   Gottesman, Michael M ^a   Ambudkar, Suresh V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ATP hydrolysis; cis(Z) flupentixol; Multidrug transporter; Photoaffinity labeling; 125I iodoarylazidoprazosin

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A; FLUPENTIXOL; GLYCOPROTEIN P; IODOARYLAZIDOPRAZOSIN; PIPERAZINE DERIVATIVE; PRAZOSIN; UNCLASSIFIED DRUG; VANADIC ACID; VINBLASTINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TRANSPORT; HUMAN; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; AFFINITY LABELS; ANIMALS; AZIDES; BINDING SITES; BIOLOGICAL TRANSPORT; CELL LINE; CYCLOSPORINE; FLUPENTHIXOL; HUMANS; INSECTS; IODINE RADIOISOTOPES; MICE; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; PRAZOSIN; RADIOLIGAND ASSAY; VANADATES; VINBLASTINE;

ANIMALIA;

EID: 0030924052     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.20.10594     Document Type: Article

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