Multidrug resistance: Can different keys open the same lock?

Drug Resistance Updates

Volumn 5, Issue 2, 2002, Pages 61-64

  Kaur, Parjit ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Binding site; BmrR; Drugs; Multidrug resistance; QacR

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN; PROTEIN; QACR PROTEIN; UNCLASSIFIED DRUG; DRUG; GLYCOPROTEIN P;

DRUG BINDING SITE; LIPOPHILICITY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; ANIMAL; BINDING SITE; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; BINDING SITES; DRUG RESISTANCE, MULTIPLE; HUMANS; P-GLYCOPROTEINS; PHARMACEUTICAL PREPARATIONS;

EID: 0036527636     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-7646(02)00020-1     Document Type: Article

References (17)

1. Multidrug resistance in Lactococcus lactis: Evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane
2. Characterization of the azidopine and vinblastine binding site of P-glycoprotein
3. Structure of MsbA from E. coli: A homolog of the multidrug resistance ATP binding cassette (ABC) transporters
4. MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition
5. Biochemistry of multidrug resistance mediated by the multidrug transporter
6. Is the multidrug transporter a flippase?
7. Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains
8. Interaction of forskolin with the P-glycoprotein multidrug transporter
9. Prevention of drug access to bacterial targets: Permeability barriers and active efflux
10. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: Membrane topology and identification of residues involved in substrate specificity
11. Proton-dependent multi-drug efflux systems
12. Structural mechanisms of QacR induction and multidrug recognition
13. P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer
14. The P-glycoprotein efflux pump: How does it transport drugs?
15. Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1
16. A structure-based mechanism for drug binding by multidrug transporters
17. Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter