Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract

Cancer Chemotherapy and Pharmacology

Volumn 54, Issue 6, 2004, Pages 525-530

  Limtrakul, Pornngarm ^a   Khantamat, Orawan ^a   Pintha, Komsak ^a  

^a Faculty of Medicine Chiang Mai University   (Thailand)

Author keywords

Biochemical modulator; Bitter melon; KB V1 cells; Momordica charantia; Multidrug resistance; P glycoprotein

Indexed keywords

ANTINEOPLASTIC AGENT; GLYCOPROTEIN P; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; MOMORDICA CHARANTIA EXTRACT; PLANT EXTRACT; VINBLASTINE;

ARTICLE; BIOACCUMULATION; BIOASSAY; CANCER CELL CULTURE; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG EXPOSURE; DRUG SENSITIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IC 50; INTERMETHOD COMPARISON; MATHEMATICAL COMPUTING; MEDICINAL PLANT; MELON; MOMORDICA CHARANTIA; MULTIDRUG RESISTANCE; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA; WILD TYPE;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; FEMALE; HUMANS; KB CELLS; MOMORDICA CHARANTIA; P-GLYCOPROTEIN; PLANT EXTRACTS; PLANT LEAVES; UTERINE CERVICAL NEOPLASMS; VINBLASTINE;

EID: 11144323815     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0848-4     Document Type: Article

References (25)

1. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR (1988) Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48:589-601
2. Anuchapreeda S, Leechanachai P, Smith MM, Ambudkar SV, Limtrakul PN (2002) Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol 64:573-582
3. Bourhis J, Benard J, Hartmann O, Boccon-Gibod L, Lemerle J, Riou G (1989) Correlation of MDR1 gene expression with chemotherapy in neuroblastoma. J Natl Cancer Inst 81:1401-1405
4. Chan HS, Thorner PS, Haddad G, Ling V (1990) Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood. J Clin Oncol 8:689-704
5. Chu TM, Lin TH, Kawinski E (1994) Detection of soluble P-glycoprotein in culture media and extracellular fluids. Biochem Biophys Res Commun 203:506-512
6. Clynes M, Daly C, NicAmhlaoibh R, Cronin D, Elliott C, O'Connor R, O'Doherty T, Connolly L, Howlett A, Scanion K (1998) Recent developments in drug resistance and apoptosis research. Crit Rev Oncol Hematol 28:181-205
7. Cole SP (1992) The 1991 Merck Frosst Award. Multidrug resistance in small cell lung cancer. Can J Physiol Pharmacol 70:313-329
8. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654
9. Cunnick JE, Sakamoto K, Chapes SK, Fortner GW, Takemoto DJ (1990) Induction of tumor cytotoxic immune cells using a protein from the bitter melon (Momordica charantia). Cell Immunol 126:278-289
10. Ford JM, Hait WN (1990) Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 42:155-199
11. Jilka C, Strifler B, Fortner GW, Hays EF, Takemoto DJ (1983) In vivo antitumor activity of the bitter melon (Momordica charantia). Cancer Res 43:5151-5155
12. Larsen AK, Escargueil AE, Skladanowski A (2000) Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmacol Ther 85:217-229
13. Lee-Huang S, Huang PL, Chen HC, Huang PL, Bourinbaiar A, Huang HI, Kung HF (1995) Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon. Gene 161:151-156
14. Lehnert M (1998) Chemotherapy resistance in breast cancer. Anticancer Res 18:2225-2226
15. Litman T, Brangi M, Hudson E, Fetsch P, Abati A, Ross DD, Miyake K, Resau JH, Bates SE (2000) The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci 113:2011-2021
16. Loe DW, Deeley RG, Cole SP (1996) Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 32A:945-957
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
18. Noonan KE, Beck C, Holzmayer TA, Chin JE, Wunder JS, Andrulis IL, Gazdar AF, Willman CL, Griffith B, Von Hoff DD (1990) Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci U S A 87:7160-7164
19. Plouzek CA, Ciolino HP, Clarke R, Yeh GC (1999) Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. Eur J Cancer 35:1541-1545
20. Robey RW, Medina-Perez WY, Nishiyama K, Lahusen T, Miyake K, Litman T, Senderowicz AM, Ross DD, Bates SE (2001) Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells. Clin Cancer Res 7:145-152
21. Schoenlein PV (1994) Role of gene amplification in drug resistance. In: Goldstein LJ, Ozols RF (eds) Anticancer drug resistance: advances in molecular and clinical research. Kluwer, Boston, MA, pp 167-200
22. Schoenlein PV, Shen DW, Barrett JT, Pastan I, Gottesman MM (1992) Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. Mol Biol Cell 3:507-520
23. Shi H, Hiramatsu M, Komatsu M, Kayama T (1996) Antioxidant property of Fructus momordicae extract. Biochem Mol Biol Int 40:1111-1121
24. Singh A, Singh SP, Bamezai R (1998) Momordica charantia (Bitter Gourd) peel, pulp, seed and whole fruit extract inhibits mouse skin papillomagenesis. Toxicol Lett 94:37-46
25. Varma MV, Ashokraj Y, Dey CS, Panchagnula R (2003) P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement. Pharmacol Res 48:347-359