Prodrug chemotherapeutics bypass p-glycoprotein resistance and kill tumors in vivo with high efficacy and target-dependent selectivity

Oncogene

Volumn 23, Issue 20, 2004, Pages 3613-3621

  Guillemard, Veronique ^a   Saragovi, H Uri ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Chemotherapy; Efficacy; Prodrug; Resistance; Selectivity; Target

Indexed keywords

DOUBLE STRANDED DNA; DOXORUBICIN; GLYCOPROTEIN P; MONOCLONAL ANTIBODY; PRODRUG; RECEPTOR ANTIBODY; SOMATOMEDIN C RECEPTOR ANTIBODY; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG EFFICACY; DRUG SELECTIVITY; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MOUSE; NASOPHARYNX TUMOR; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; IMMUNOTOXINS; MICE; MICE, NUDE; P-GLYCOPROTEIN; PRODRUGS;

ANIMALIA;

EID: 2442666714     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207463     Document Type: Article

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