Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype

Cancer Research

Volumn 61, Issue 10, 2001, Pages 4030-4037

  Mi, Qiuwen ^a   Cui, Baoliang ^a   Silva, Gloria L ^a   Lantvit, Daniel ^a   Lim, Eula ^a   Chai, Heebyung ^a   You, Min ^a   Hollingshead, Melinda G ^b   Mayo, Joseph G ^b   Kinghorn, A Douglas ^a   Pezzuto, John M ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; PERVILLEINE A; TROPANE ALKALOID; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CANCER CHEMOTHERAPY; CELL GROWTH; CHEMOSENSITIVITY; COMPETITIVE INHIBITION; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARGET CELL; TUMOR CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CELL DIVISION; COLCHICINE; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, MDR; HUMANS; INHIBITORY CONCENTRATION 50; KB CELLS; P-GLYCOPROTEIN; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TROPANES; TUMOR CELLS, CULTURED; VERAPAMIL; VINBLASTINE;

EID: 0035872402     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Biochemistry of multidrug resistance mediated by the multidrug transporter
2. 3H]vinblastine transport by isolated vesicles
3. In vivo model systems in P-glycoprotein-mediated multidrug resistance
4. Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979
5. Pharmacology of drugs that alter multidrug resistance in cancer
6. Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A, and verapamil on multidrug resistance in vitro and in vivo
7. Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance
8. The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans
9. New multidrug-resistance-reversing drags, MS-209 and SDZ PSC 833
10. S9788 modulation of P-glycoprotein and multidrug-related protein-mediated multidrug resistance by Servier 9788 in doxorubicin-resistant MCF7 cells
11. In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
12. Circumvention of vincristine and adriamycin resistance in vitro and in vivo by calcium influx blockers
13. Cure of mice bearing P388 leukemia by vincristine in combination with a calcium channel blocker
14. In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52
15. Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukemia in mice
16. In vivo reversal of multidrug resistance by two new dihydropyridine derivatives, S16317 and S16324
17. The clinical relevance of multidrug resistance
18. Systemic toxic effects associated with high-dose verapamil infusion and chemotherapy administration
19. Inhibitors of multidrug resistance
20. Recent progress in P-glycoprotein research
21. Modulation of multidrug resistance: A paradigm for translational clinical research in oncology and hematology
22. Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance
23. Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells
24. Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells
25. Short-term in vivo cultivation of human tumor cell lines for assess ng potential chemotherapeutic agents
26. Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model
27. In vivo cultivation of tumor cells in hollow fibers
28. Altered surface membrane glycoproteins in vinca alkaloid-resistant human leukemic lymphoblasts
29. Reversal of vinca alkaloid resistance but not multiple drug resistance in human leukemic cells by verapamil
30. Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells
31. 13C-NMR assignments of phyllanthin and hypophyllanthin: Lignans that enhance cytotoxic responses with cultured multidrug-resistant cells
32. Cancer chemopreventive activity mediated by 4′-bromoflavone, a potent inducer of Phase II detoxification enzymes
33. Reduced drug accumulation in multiple drug-resistance human KB carcinoma cell lines
34. Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening
35. The specific bisindolylmaleimide PKC-inhibitor GF109203X efficiently modulates MRP-associated multiple drug resistance
36. In vitro spermicidal activity of gossypol
37. Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins
38. 10 substituted phenoxazines for reversing multidrug resistance in cancer cells
39. Verapamil decreased P-glycoprotein expression in multidrug-resistant human leukemic cell lines
40. Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance
41. Effects of modulators of multidrug resistance on the expression of the MDR1 gene in human KB cells in culture
42. Molecular and cellular biology of multidrug resistance in tumor cells
43. Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein
44. Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents
45. Kinetics of the multidrug transporter (P-glycoprotein) its reversal
46. Quantitative structure-activity relationship of multidrug resistance reversal agents
47. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells
48. The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multidrug transporter
49. Structure-activity study and design of multidrug-resistant reversal compounds by a computer automated structure evaluation methodology
50. Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells: Implications for anticancer drug screening programs