ARTICLE;
CELL TRANSPORT;
CHEMOSENSITIVITY;
CONTROLLED STUDY;
DRUG ACCUMULATION;
DRUG BINDING SITE;
DRUG EFFECT;
DRUG HYDROXYLATION;
DRUG POTENCY;
DRUG SCREENING;
ENZYME ACTIVITY;
HUMAN;
HUMAN CELL;
MULTIDRUG RESISTANCE;
PRIORITY JOURNAL;
STRUCTURE ACTIVITY RELATION;
SUBSTITUTION REACTION;
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Cole S.P., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M., Deeley R.G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 258:1992;1650-1654
Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability
Riordan J.R., Ling V. Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability. J. Biol. Chem. 254:1979;12701-12705
Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line
Maliepaard M., van Gastelen M.A., de Jong L.A., Pluim D., van Waardenburg R.C., Ruevekamp-Helmers M.C., Floot B.G., Schellens J.H. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res. 59:1999;4559-4563
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
Tsuruo T., Iida H., Tsukagoshi S., Sakurai Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res. 41:1981;1967-1972
Cyclosporin a and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line
Twentyman P.R., Fox N.E., White D.J. Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line. Br. J. Cancer. 56:1987;55-57
Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein
Conseil G., Baubichon-Cortay H., Dayan G., Jault J.M., Barron D., Di Pietro A. Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein. Proc. Natl. Acad. Sci. USA. 95:1998;9831-9836
Drug concentration-dependent expression of multidrug resistance- associated protein and P-glycoprotein in the doxorubicin-resistant acute myelogenous leukemia sublines
Choi C.H., Kim H.S., Rha H.S., Jeong J.H., Park Y.H., Min Y.D., Kee K.H., Lim D.Y. Drug concentration-dependent expression of multidrug resistance-associated protein and P-glycoprotein in the doxorubicin-resistant acute myelogenous leukemia sublines. Mol. Cell. 9:1999;314-319
Adaptation of the rapid automated tetrazolium dye based (MTT) assay for chemosensitivity testing in childhood leukemia
Pieters R., Huismans D.R., Leyva A., Veerman A.J. Adaptation of the rapid automated tetrazolium dye based (MTT) assay for chemosensitivity testing in childhood leukemia. Cancer Lett. 41:1988;323-332
Role of glycine-534 and glycine-1179 of human multidrug resistance protein (MDR1) in drug-mediated control of ATP hydrolysis
Szakacs G., Ozvegy C., Bakos E., Sarkadi B., Varadi A. Role of glycine-534 and glycine-1179 of human multidrug resistance protein (MDR1) in drug-mediated control of ATP hydrolysis. Biochem. J. 356:2001;71-75
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
Ozvegy C., Litman T., Szakacs G., Nagy Z., Bates S., Varadi A., Sarkadi B. Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem. Biophys. Res. Commun. 285:2001;111-117
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576
Mistry P., Stewart A.J., Dangerfield W., Okiji S., Liddle C., Bootle D., Plumb J.A., Templeton D., Charlton P. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res. 61:2001;749-758
Photoaffinity labeling of P-glycoprotein in multidrug resistant cells with photoactive analogs of colchicine
Safa A.R., Mehta N.D., Agresti M. Photoaffinity labeling of P-glycoprotein in multidrug resistant cells with photoactive analogs of colchicine. Biochem. Biophys. Res. Commun. 162:1989;1402-1408
Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941
Kajiji S., Dreslin J.A., Grizzuti K., Gros P. Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941. Biochemistry. 33:1994;5041-5048
Medroxyprogesterone-acetate reverses the MDR phenotype of the CG5-doxorubicin resistant human breast cancer cell line
Zibera C., Gibelli N., Maestri L., Della Cuna G.R. Medroxyprogesterone- acetate reverses the MDR phenotype of the CG5-doxorubicin resistant human breast cancer cell line. Anticancer Res. 15:1995;745-749
Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane
Loo T.W., Clarke D.M. Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane. J. Biol. Chem. 275:2000;39272-39278
The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface
Loo T.W., Clarke D.M. The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface. J. Biol. Chem. 274:1999;24759-24765
Azidopine noncompetitively interacts with vinblastine and cyclosporin a binding to P-glycoprotein in multidrug resistant cells
Tamai I., Safa A.R. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. J. Biol. Chem. 266:1991;16796-16800
Partial purification and reconstitution of the human multidrug-resistance pump: Characterization of the drug-stimulatable ATP hydrolysis
Ambudkar S.V., Lelong I.H., Zhang J., Cardarelli C.O., Gottesman M.M., Pastan I. Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc. Natl. Acad. Sci. USA. 89:1992;8472-8476
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells
Hamada H., Tsuruo T. Characterization of the ATPase activity of the Mr 170, 000 to 180, 000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 48:1988;4926-4932
Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein
Sharom F.J., Yu X., Doige C.A. Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein. J. Biol. Chem. 268:1993;24197-24202
Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein
Watanabe T., Kokubu N., Charnick S.B., Naito M., Tsuruo T., Cohen D. Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein. Br. J. Pharmacol. 122:1997;241-248
Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein
Shepard R.L., Winter M.A., Hsaio S.C., Pearce H.L., Beck W.T., Dantzig A.H. Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein. Biochem. Pharmacol. 56:1998;719-727
Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: Structure-activity relationships for flavonoid binding
de Wet H., McIntosh D.B., Conseil G., Baubichon-Cortay H., Krell T., Jault J.M., Daskiewicz J.B., Barron D., Di Pietro A. Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding. Biochemistry. 40:2001;10382-10391
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
De Azevedo W.F. Jr., Mueller-Dieckmann H.J., Schulze-Gahmen U., Worland P.J., Sausville E., Kim S.H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA. 93:1996;2735-2740
A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein
Penzotti J.E., Lamb M.L., Evensen E., Grootenhuis P.D. A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein. J. Med. Chem. 45:2002;1737-1740
