ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

British Journal of Pharmacology

Volumn 126, Issue 3, 1999, Pages 681-688

  Renes, Johan ^a,b   De Vries, Elisabeth G E ^b   Nienhuis, Edith F ^b   Jansen, Peter L M ^a   Müller, Michael ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

ABC transporter; APDA; ATP dependent drug transport; Daunorubicin; Drug resistance; GSH; MDRI; MRPI; Vincristine

Indexed keywords

ADENOSINE TRIPHOSPHATE; DAUNORUBICIN; GLUTATHIONE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; VERLUKAST; VINCRISTINE;

ARTICLE; DRUG TRANSPORT; HUMAN; HUMAN CELL; MEMBRANE VESICLE; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; AJMALINE; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CATIONS; DAUNORUBICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HUMANS; IMMUNOBLOTTING; LEUKOTRIENE C4; MEMBRANES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; TRITIUM; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0033021424     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702360     Document Type: Article

References (48)

1. BARNOUIN, K., LEIER, I., JEDLITSCHKY, G., POURTIER-MANZANEDO, A., KÖNIG, J., LEHMAN, W-D. & KEPPLER, D. (1998). Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. Br. J. Cancer, 77, 201-209.
2. BORST, P. & SCHINKEL, A.H. (1997). Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet., 13, 217-221.
3. BOWMAN, E.J., SIEBERS, A. & ALTENDORF, K. (1988). Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc. Natl. Acad. Sci. U.S.A., 85, 7972-7976.
4. BROXTERMAN, H.J., GIACCONE, G. & LANKELMA, J. (1995). MRP and other drug transport-related resistance to natural product agents. Curr. Opin. Oncol., 7, 532-540.
5. BURGER, H., NOOTER, K., ZAMAN, G.J.R., SONNEVELD, P., VAN WINGERDEN, K.E., OOSTRUM, R.G. & STOTER, G. (1994). Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. Leukemia, 8, 990-997.
6. COLE, S.P.C., BHARDWAJ, G., GERLACH, J.H., MACKIE, J.E., GRANT, C.E., ALMQUIST, K.C., STEWART, A.J., KURZ, E.U., DUNCAN, A.M. & DEELEY, R.G. (1992). Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science, 258, 1650-1654.
7. DONG, M., PENIN, F. & BAGGETTO, L.G. (1996). Efficient purification and reconstitution of P-glycoprotein for functional and structural studies. J. Biol. Chem., 271, 28875-28883.
8. 4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance. Biochem. Biophys. Res. Commun., 208, 345-352.
9. GERMANN, U.A. (1996). P-glycoprotein - A mediator of multidrug resistance in tumour cells. Eur. J. Cancer, 32A, 927-944.
10. +-ATPase. Annu. Rev. Physiol., 58, 427-445.
11. GOTTESMAN, M.M. & PASTAN, I. (1993). Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62, 385-427.
12. HIGGINS, C.F. (1992). ABC transporters: from microorganism to man. Annu. Rev. Cell Biol., 67, 113.
13. r 190,000 multidrug resistance protein, MRP, with monoclonal antibodies. Cancer Res., 54, 5788-5792.
14. HORIO, M., GOTTESMAN, M.M. & PASTAN, I. (1988). ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc. Natl. Acad. Sci. U.S.A., 85, 3580-3584.
15. ISHIKAWA, T., AKIMARU, K., KUO, M.T., PRIEBE, W. & SUZUKI, M. (1995). How does the MRP/GS-X pump export doxorubicin? J. Natl. Cancer Inst., 87, 1639-1640.
16. JEDLITSCHKY, G., LEIER, I., BUCHHOLZ, U., BARNOUIN, K., KURZ, G. & KEPPLER, D. (1996). Transport of glutathione, glucuronate and sulphate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res., 56, 988-994.
17. 4 receptor antagonist Can. J. Physiol. Pharmacol., 67, 17-28.
18. JULIANO, R.L. & LING, V. (1976). A surface glycoprotein modulating drug permeability in chinese hamster ovary cell mutants. Biochim. Biophys. Acta., 455, 152-162.
19. KAMIMOTO, Y., GATMAITAN, Z., HSU, J. & ARIAS, I.M. (1989). The function of Gp170, the multidrug resistance gene product in rat liver canalicular membrane vesicles. J. Biol. Chem., 264, 11693-11698.
20. KOOL, M., DE HAAS, M., SCHEFFER, G.L., SCHEPER, R.J., VAN EIJK, M.J.T., JUIJN, J.A., BAAS, F. & BORST, P. (1997). Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res., 57, 3537-3547.
21. 4 and structurally related conjugates. J. Biol. Chem., 269, 27807-27810.
22. LOE, D.W., ALMQUIST, K.C., COLE, S.P.C. & DEELEY, R.G. (1996a). ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). J. Biol. Chem., 271, 9683-9689.
23. 4 and chemotherapeutic agents in membrane vesicles. J. Biol. Chem., 271, 9675-9682.
24. LOE, D.W., DEELEY, R.G. & COLE, S.P.C. (1996c). Biology of the multidrug resistance-associated protein, MRP. Eur. J. Cancer, 32A, 945-957.
25. 1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. Mol. Pharmacol., 51, 1034-1041.
26. MELLMAN, I., FUCHS, R. & HELENIUS, A. (1986). Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem., 55, 663-700.
27. MÜLLER, M., MAYER, R., HERO, U. & KEPPLER, D. (1994a). ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P-glycoprotein. FEBS. Lett., 343, 168-172.
28. MÜLLER, M., MEIJER, C., ZAMAN, G.J.R., BORST, P., SCHEPER, R.J., MULDER, N.H., DE VRIES, E.G.E. & JANSEN, P.L.M. (1994b). Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. U.S.A., 91, 13033-13037.
29. MÜLLER, M., ROELOFSEN, H. & JANSEN, P.L.M. (1996). Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein. Semin. Liver Dis., 16, 211-220.
30. O'BRIEN, M.L. & TEW, K.D. (1996). Glutathione and related enzymes in multidrug resistance. Eur. J. Cancer, 32A, 967-978.
31. 4 transport mediated by MRP/GS-X pump. Biochem. Biophys. Res. Commun., 247, 859-863.
32. RAPPA, G., LORICO, A., FLAVELL, R.A. & SARTORELLI, A.C. (1997). Evidence that the multidrug resistance protein (MRP) functions as a co-transporter for glutathione and natural product drugs. Cancer Res., 57, 5232-5237.
33. ROELOFSEN, H., VOS, T.A., SCHIPPERS, I.J., KUIPERS, F., KONING, H., MOSHAGE, H., JANSEN, P.L.M. & MÜLLER, M. (1997). Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology, 112, 511-521.
34. ROGAN, A.M., HAMILTON, T.C., YOUNG, R.C., KLECKER, R.W. & OZOLS, R.F. (1984). Reversal of adriamycin resistance by verapamil in human ovarium cancer. Science, 224, 994-996.
35. RUETZ, S. & GROS, P. (1994a). A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? Trends Pharmacol. Sci., 15, 260-263.
36. RUETZ, S. & GROS, P. (1994b). Functional expression of P-glycoproteins in secretory vesicles. J. Biol. Chem., 269, 12277-12284.
37. SHAPIRO, A.B. & LING, V. (1994). ATPase activity of purified and reconstituted P-glycoprotein from chinese hamster ovary cells. J. Biol. Chem., 269, 3745-3754.
38. SHAROM, F.J., YU, X., CHU, J.W.K. & DOIGE, C.A. (1995). Characterization of the ATPase activity of P-glycoprotein from multidrug resistant chinese hamster ovary cells. Biochem. J., 308, 381-390.
39. TAGUCHI, Y., YOSHIDA, A., TAKADA, Y., KOMANO, T. & UEDA, K. (1997). Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide on multidrug resistance-associated protein (MRP). FEBS Lett., 401, 11-14.
40. TAMAI, I. & SAFA, A.R. (1990). Competitive interaction of cyclosporins with the vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. J. Biol. Chem., 265, 16509-16513.
41. TEW, K.D. (1994). Glutathione associated enzymes in anticancer drug resistance. Cancer Res., 54, 4313-4320.
42. URBATSCH, I.L., SANKARAN, B., WEBER, J. & SENIOR, A.E. (1995). P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site. J. Biol. Chem., 270, 19383-19390.
43. VAN LUYN, M.J.A., MÜLLER, M., RENES, J., MEIJER, C., SCHEPER, R.J., NIENHUIS, E.F., MULDER, N.H., JANSEN, P.L.M. & DE VRIES, E.G.E. (1998). Transport of glutathione conjugates into secretory vesicles is mediated by the multidrug-resistance protein 1. Int. J. Cancer, 76, 55-62.
44. VERSANTVOORT, C.H.M., BROXTERMAN, H.J., BAGRIJ, T., SCHEPER, R.J. & TWENTYMAN, P.R. (1995). Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br. J. Cancer, 72, 82-89.
45. ZAMAN, G.J.R., FLENS, M.J., VAN LEUSDEN, M.R., DE HAAS, M., MULDER, H.S., LANKELMA, J., PINEDO, H.M., SCHEPER, R.J., BAAS, F., BROXTERMAN, H.J. & BORST, P. (1994). The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc. Natl. Acad. Sci. U.S.A., 91, 8822-8826.
46. ZAMAN, G.J.R., LANKELMA, J., VAN TELLINGEN, O., BEIJNEN, J., DEKKER, H., PAULUSMA, C., OUDE ELFERINK, R.P.J., BAAS, F. & BORST, P. (1995). Role of glutathione in the export of compounds from cells by the multidrug-associated protein. Proc. Natl. Acad. Sci. U.S.A., 92, 7690-7694.
47. ZAMAN, G.J.R., VERSANTVOORT, C.H., SMIT, J.J., EIJDEMS, E.W., DE HAAS, M., SMITH, A.J., BROXTERMAN, H.J., MULDER, N.H., DE VRIES, E.G.E., BAAS, F. & BORST, P. (1993). Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res., 53, 1747-1750.
48. ZIJLSTRA, J.G., DE VRIES, E.G.E. & MULDER, N.H. (1987). Multi-factorial drug resistance in an adriamycin resistant human small cell lung carcinoma cell line. Cancer Res., 47, 1780-1784.