Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: Role of P-glycoprotein as a barrier to in vivo ocular drug absorption

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 1, 2004, Pages 246-255

  Dey, Surajit ^a   Gunda, Sriram ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; ERYTHROMYCIN; GLYCOPROTEIN P; QUINIDINE; TESTOSTERONE; VERAPAMIL;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA CELL; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG TRANSPORT; GENE; GENETIC TRANSFECTION; IN VIVO STUDY; INFUSION; MDR 1 GENE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; RABBIT; SINGLE DRUG DOSE;

ABSORPTION; AMINO ACID SEQUENCE; ANIMALS; AREA UNDER CURVE; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CELL DIVISION; CELLS, CULTURED; CORNEA; DIAZEPAM; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROMYCIN; EYE; HUMANS; MALE; MANNITOL; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 4644240426     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.069583     Document Type: Article

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