Determining the Dimensions of the Drug-binding Domain of Human P-glycoprotein Using Thiol Cross-linking Compounds as Molecular Rulers

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 36877-36880

  Loo, Tip W ^b   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOLOGICAL MEMBRANES; CROSSLINKING; DRUG THERAPY; GELS; MUTAGENESIS; PROTEINS;

TRANSMEMBRANE SEGMENTS;

BIOCHEMISTRY;

1,2 ETHANEDIYL BISMETHANETHIOSULFONATE; 1,3 PROPANEDIYL BISMETHANETHIOSULFONATE; 1,4 BUTANEDIYL BISMETHANETHIOSULFONATE; 1,5 PENTANEDIYL BISMETHANETHIOSULFONATE; 1,6 HEXANEDIYL BISMETHANETHIOSULFONATE; 3,6 DIOXAOCTANE 1,8 DIYL BISMETHANETHIOSULFONATE; 3,6,9 TRIOXAUNDECANE 1,11 BISMETHANETHIOSULFONATE; 3,6,9,12 TETRAOXATETRADECANE 1,14 DIYL BISMETHANETHIOSULFONATE; 3,6,9,12,15 PENTAOXAHEPTADECANE 1,17 DIYL BISMETHANETHIOSULFONATE; ADENOSINE TRIPHOSPHATASE; CYCLOSPORIN A; CYSTEINE; GLYCOPROTEIN P; METHANETHIOSULFONATE; MUTANT PROTEIN; REAGENT; SULFONIC ACID DERIVATIVE; THIOL CROSS LINKING AGENT; UNCLASSIFIED DRUG; VINBLASTINE; CROSS LINKING REAGENT; THIOL DERIVATIVE;

ARTICLE; BINDING SITE; CROSS LINKING; CYTOPLASM; DRUG BINDING; DRUG BINDING DOMAIN; DRUG STRUCTURE; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; MOLECULAR RULER; MOLECULE; MULTIDRUG RESISTANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; CELL CULTURE; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

CELLS, CULTURED; CROSS-LINKING REAGENTS; HUMANS; P-GLYCOPROTEIN; PROTEIN STRUCTURE, TERTIARY; SULFHYDRYL COMPOUNDS;

EID: 0035813143     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C100467200     Document Type: Article

References (57)

1. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I., and Gottesman, M. M. (1999) Annu. Rev. Pharmacol. Toxicol. 39, 361-398
2. Kim, R. B., Fromm, M. F., Wandel, C., Leake, B., Wood, A. J., Roden, D. M., and Wilkinson, G. R. (1998) J. Clin. Invest. 101, 289-294
3. Lee, C. G., Gottesman, M. M., Cardarelli, C. O., Ramachandra, M., Jeang, K. T., Ambudkar, S. V., Pastan, I., and Dey, S. (1998) Biochemistry 37, 3594-3601
4. Robert, J. (1999) Eur. J. Clin. Invest. 29, 536-545
5. Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 7735-7738
6. Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M. R., and Bertino, J. R. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 695-698
7. Schinkel, A. H., Smit, J. J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P., Berns, A. J. M., and Borst, P. (1994) Cell 77, 491-502
8. Higgins, C. F. (1992) Annu. Rev. Cell Biol. 8, 67-113
9. Chen, C. J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., and Roninson, I. B. (1986) Cell 47, 381-389
10. Loo, T. W., and Clarke, D. M. (1995) J. Biol. Chem. 270, 843-848
11. Kast, C., Canfield, V., Levenson, R., and Gros, P. (1996) J. Biol. Chem. 271, 9240-9248
12. Loo, T. W., and Clarke, D. M. (1996) J. Biol. Chem. 271, 27488-27492
13. Azzaria, M., Schurr, E., and Gros, P. (1989) Mol. Cell. Biol. 9, 5289-5297
14. Loo, T. W., and Clarke, D. M. (1994) J. Biol. Chem. 269, 7750-7755
15. Loo, T. W., and Clarke, D. M. (1995) J. Biol. Chem. 270, 22957-22961
16. Urbatsch, I. L., Sankaran, B., Bhagat, S., and Senior, A. E. (1995) J. Biol. Chem. 270, 26956-26961
17. Hrycyna, C. A., Ramachandra, M., Ambudkar, S. V., Ko, Y. H., Pedersen, P. L., Pastan, I., and Gottesman, M. M. (1998) J. Biol. Chem. 273, 16631-16634
18. Loo, T. W., and Clarke, D. M. (2000) J. Natl. Cancer Inst. 92, 898-902
19. Senior, A. E., and Gadsby, D. C. (1997) Semin Cancer Biol 8, 143-150
20. Walmsley, A. R., Zhou, T., Borges-Walmsley, M. I., and Rosen, B. P. (2001) J. Biol. Chem. 276, 6378-6391
21. Bruggemann, E. P., Currier, S. J., Gottesman, M. M., and Pastan, I. (1992) J. Biol. Chem. 267, 21020-21026
22. Greenberger, L. M. (1993) J. Biol. Chem. 268, 11417-11425
23. Morris, D. I., Greenberger, L. M., Bruggemann, E. P., Cardarelli, C., Gottesman, M. M., Pastan, I., and Seamon, K. B. (1994) Mol. Pharmacol. 46, 329-337
24. Zhang, X., Collins, K. I., and Greenberger, L. M. (1995) J. Biol. Chem. 270, 5441-5448
25. Demmer, A., Thole, H., Kubesch, P., Brandt, T., Raida, M., Fislage, R., and Tummler, B. (1997) J. Biol. Chem. 272, 20913-20919
26. Demeule, M., Laplante, A., Murphy, G. F., Wenger, R. M., and Beliveau, R. (1998) Biochemistry 37, 18110-18118
27. Gros, P., Dhir, R., Croop, J., and Talbot, F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 7289-7293
28. Kajiji, S., Talbot, F., Grizzuti, K., Van Dyke-Phillips, V., Agresti, M., Safa, A. R., and Gros, P. (1993) Biochemistry 32, 4185-4194
29. Loo, T. W., and Clarke, D. M. (1993) J. Biol. Chem. 268, 3143-3149
30. Loo, T. W., and Clarke, D. M. (1993) J. Biol. Chem. 268, 19965-19972
31. Loo, T. W., and Clarke, D. M. (1994) Biochemistry 33, 14049-14057
32. Loo, T. W., and Clarke, D. M. (1999) J. Biol. Chem. 274, 24759-24765
33. Falke, J. J., and Koshland, D. E., Jr. (1987) Science 237, 1596-1600
34. Yu, H., Kono, M., McKee, T. D., and Oprian, D. D. (1995) Biochemistry 34, 14963-14969
35. Frillingos, S., Sahin-Toth, M., Wu, J., and Kaback, H. R. (1998) FASEB J. 12, 1281-1299
36. Bass, R. B., and Falke, J. J. (1999) Structure Fold Des. 7, 829-840
37. Jiang, W., and Fillingame, R. H. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6607-6612
38. Loo, T. W., and Clarke, D. M. (1997) J. Biol. Chem. 272, 31945-31948
39. Loo, T. W., and Clarke, D. M. (1999) J. Biol. Chem. 274, 35388-35392
40. Loo, T. W., and Clarke, D. M. (2000) J. Biol. Chem. 275, 39272-39278
41. Loo, T. W., and Clarke, D. M. (2001) J. Biol. Chem. 276, 14972-14979
42. Loo, T. W., and Clarke, D. M. (1996) J. Biol. Chem. 270, 21449-21452
43. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5463-5467
44. Loo, T. W., and Clarke, D. M. (1997) J. Biol. Chem. 272, 709-712
45. Chifflet, S., Torriglia, A., Chiesa, R., and Tolosa, S. (1988) Anal. Biochem. 168, 1-4
46. Kenyon, G. L., and Bruice, T. W. (1977) Methods Enzymol. 47, 407-430
47. Bruice, T. W., and Kenyon, G. L. (1982) J. Protein Chem. 1, 47-58
48. Ambudkar, S. V., Cardarelli, C. O., Pashinsky, I., and Stein, W. D. (1997) J. Biol. Chem. 272, 21160-21166
49. Loo, T. W., and Clarke, D. M. (1996) J. Biol. Chem. 271, 27482-27487
50. Loo, T. W., and Clarke, D. M. (1997) J. Biol. Chem. 272, 20986-20989
51. Chan, H. S., Grogan, T. M., DeBoer, G., Haddad, G., Gallie, B. L., and Ling, V. (1996) Eur. J. Cancer 6, 1051-1061
52. Bau, R., and Jin, K. K. (2000) J. Chem. Soc. Perkin Trans. I, 2079-2082
53. Jegorov, A., Cvak, L., Husek, A., Simek, P., Heydova, A., Ondracek, J., Pakhomova, S., Husak, M., Kratochvil, B., Sedmera, P., and Havlicek, V. (2000) Collect. Czech. Chem. Commun. 65, 1317-1326
54. Loo, T. W., and Clarke, D. M. (2000) J. Biol. Chem. 275, 5253-5256
55. Green, N. S., Reisler, E., and Houk, K. N. (2001) Protein. Sci. 10, 1293-1304
56. Rosenberg, M. F., Callaghan, R., Ford, R. C., and Higgins, C. F. (1997) J. Biol. Chem. 272, 10685-10694
57. Loo, T. W., and Clarke, D. M. (2001) J. Biol. Chem. 276, 31800-31805