P-glycoprotein regulated transport of glutamate at blood-brain barrier

Acta Pharmacologica Sinica

Volumn 22, Issue 2, 2001, Pages 111-116

  Liu, X D ^a   Liu, G Q ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Cyclosporins; Glutamates; Glycoproteins; Verapamil; Vincristine

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A; GLUTAMIC ACID; GLYCOPROTEIN P; TRITIUM; VERAPAMIL; VINCRISTINE; CYCLOSPORIN;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN PERFUSION; CAPILLARY ENDOTHELIUM; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; MALE; MICROINJECTION; NONHUMAN; PERMEABILITY; RAT; REGULATORY MECHANISM; STEADY STATE; ANIMAL; BRAIN; CELL CULTURE; CYTOLOGY; MULTIDRUG RESISTANCE; RAT STRAIN; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMAL; BLOOD-BRAIN BARRIER; BRAIN; CATTLE; CELLS, CULTURED; CYCLOSPORINE; DRUG RESISTANCE, MULTIPLE; ENDOTHELIUM, VASCULAR; GLUTAMIC ACID; MALE; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; VERAPAMIL; VINCRISTINE;

EID: 0035137293     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Glutamate is transported across the rat blood-brain barrier by a sodium-independent system
2. Glutamate transport across blood brain barrier after transient global ischemia/reperfusion in rats
3. Functional involvement of P-glycoprotein in blood-brain barrier
4. The multidrug-resistance P-glycoprotein is an early marker of blood-brain development in the microvessels of the developing human brain
5. Restricted transport of cyclosprin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein
6. The effects of verapamil on the transport of peptides across the blood-brain barrier in rats: Kinetic evidence for an apically polarized efflux mechanism
7. In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier
8. 3H]GABA across blood-brain barrier after cerebral ischemiareperfusion in rats
9. An in situ brain perfusion technique to study cerebrovascular transport in the rat
10. Transport of monocarboxylic acids at the blood-brain barrier: Studies with monolayers of primary cultured bovine brain capillary endothelial cells
11. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
12. Competive interaction of Cyclosporins with the vinca alkaloid-binding site of P-glycoprotein in multidrugresistant cells
13. Biochemical discrimination between luminal and abluminal enzyme and transport activities of the blood-brain barrier
14. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the bloodbrain barrier and to increased sensitivity to drugs
15. Evidence for the involvement of P-glycoprotein on the extrusion of taken up L-DOPA in cyclosporine A treated LLC-PK1 cells