A practical total synthesis of hapalosin, a 12-membered cyclic depsipeptide with multidrug resistance-reversing activity, by employing improved segment coupling and macrolactonization

Journal of Organic Chemistry

Volumn 69, Issue 12, 2004, Pages 4126-4134

  Palomo, Claudio ^a   Oiarbide, Mikel ^a   García, Jesús M ^b   González, Alberto ^b   Pazos, Raquel ^a   Odriozola, José M ^b   Bañuelos, Patricia ^b   Tello, Mónica ^b   Linden, Anthony ^c  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b PUBLIC UNIVERSITY OF NAVARRE   (Spain)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBOXYLIC ACIDS; DRUG PRODUCTS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

HAPALOSIN; MULTIDRUG RESISTANCE;

AROMATIC COMPOUNDS;

ACETIC ACID; AMINO ACID; CAMPHOR; GAMMA AMINO BETA HYDROXYCARBOXYLIC ACID; HAPALOSIN; LITHIUM ACETATE; UNCLASSIFIED DRUG;

ADDITION REACTION; ALDOL REACTION; CHIRALITY; CONFERENCE PAPER; CYCLIZATION; DEPROTECTION REACTION; DRUG ACTIVITY; DRUG SYNTHESIS; MACROLACTONIZATION; MULTIDRUG RESISTANCE; STEREOCHEMISTRY;

DEPSIPEPTIDES; DRUG RESISTANCE, MULTIPLE; LACTAMS; LACTONES; PEPTIDES, CYCLIC;

EID: 2942564141     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0497499     Document Type: Conference Paper

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