A structural model for the open conformation of the mdr1 P-glycoprotein based on the MsbA crystal structure

Journal of Biological Chemistry

Volumn 278, Issue 32, 2003, Pages 30115-30124

  Seigneuret, Michel ^a,c   Garnier Suillerot, Arlette ^b  

^a CNRS   (France)

^b UNIVERSITÉ PARIS 13   (France)

^c INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; DIMERS; ESCHERICHIA COLI; LIPIDS; PROTEINS;

INTRACELLULAR DOMAIN;

BIOCHEMISTRY;

CARRIER PROTEIN; GLYCOPROTEIN P; MSBA PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEOTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ESCHERICHIA COLI; MOLECULAR MODEL; MOLECULAR SIZE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TRANSPORT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; CRYSTALLOGRAPHY, X-RAY; CYTOPLASM; DIMERIZATION; ESCHERICHIA COLI; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI;

EID: 0042531543     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302443200     Document Type: Article

References (66)

1. Higgins, C. F. (2001) Res. Microbiol. 152, 365-374
2. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I., and Gottesman, M. M. (1999) Annu. Rev. Pharmacol. Toxicol. 39, 361-398
3. Borst, P., Zelcer, N., and Van Helvoort, A. (2000) Biochim. Biophys. Acta 1486, 128-144
4. Small, D. M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4-6
5. Higgins, C. F., and Gottesman, M. M. (1992) Trends Biochem. Sci. 17, 18-21
6. Pohl, A., Lage, H., Muller, P., Pomorski, T., and Herrmann, A. (2002) Biochem. J. 365, 259-268
7. Garrigues A., Escargueil A. E., and Orlowski, S. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 10347-10352
8. Loo, T. W., and Clarke, D. M. (1999) Biochim. Biophys. Acta 1461, 315-325
9. Rosenberg, M. F., Callaghan, R., Ford, R. C., and Higgins, C. F. (1997) J. Biol. Chem. 272, 10685-10694
10. Chang, G., and Roth, C. B. (2001) Science 293, 1793-1800
11. Chami, M., Steinfels, E., Orelle, C., Jault, J. M., Di Pietro, A., and Rigaud, J. L. (2002) J. Mol. Biol. 315, 1075-1085
12. Lee, J. Y., Urbatsch, I. L., Senior, A. E., and Wilkens, S. (2002) J. Biol. Chem. 277, 40125-40131
13. Locher, K. P., Lee, A. T., and Rees, D. C. (2002) Science 296, 1091-1098
14. Rosenberg, M. F., Kamis, A. B., Callaghan, R., Higgins, C. F., and Ford, R. C. (2003) J. Biol. Chem. 278, 8294-8299
15. Jones, P. M., and George, A. M. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 12639-12644
16. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res., 24, 4876-4882
17. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
18. Koradi, R., Billeter, M., and Wuthrich, K. (1996) J. Mol. Graph. 51, 29-32
19. Vriend, G. J. (1990) Mol. Graph. 8, 526-529
20. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
21. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
22. Gaudet, R., and Wiley, D. C. (2001) EMBO J. 20, 4964-4972
23. Hrycyna, C. A., Airan, L. E., Germann, U. A., Ambudkar, S. V., Pastan, I., and Gottesman, M. M. (1998) Biochemistry 37, 13660-13673
24. Fiser, A., Do, R. K., and Sali, A. (2000) Protein Sci. 9, 1753-1773
25. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
26. Nicholls, A., Sharp, K., and Honig, B. (1991) Proteins 11, 281-287
27. Yang, A. S., and Honig, B. (2000) J. Mol. Biol. 301, 679-689
28. McDonald, M. K., Cowley, S. C., and Nano, F. E. (1997) J. Bacteriol. 179, 7638-7643
29. Poelarends, G. J., Mazurkiewicz, P., and Konings, W. N. (2002) Biochim. Biophys. Acta 1555, 13-17
30. Sakamoto, K., Golles, A., Van Veen, H. W., and Konings, W. N. (2001) J. Bacteriol. 183, 5371-5375
31. Otto, M., and Gotz, F. (2001) Res. Microbiol. 152, 351-356
32. Klucken, J., Buchler, C., Orso, E., Kaminski, W. E., Porsch Ozcurumez, M., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M., Allikmets, R., and Schmitz, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 817-821
33. Rost, B. (1996) Methods Enzymol. 266, 525-539
34. Senes, A., Gerstein, M., and Engelman, D. M. (2000) J. Mol. Biol. 296, 921-936
35. Eilers, M., Shekar, S. C., Shieh, T., Smith, S. O., and Fleming, P. J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5796-5801
36. Dawson, J. P., Weinger, J. S and Engelman, D. M. (2002) J. Mol. Biol. 316, 799-805
37. Liang, J. (2002) Curr. Opin. Chem. Biol. 6, 878-884
38. Eilers, M., Patel, A. B., Liu, W., and Smith, S. O. (2002) Biophys. J. 82, 2720-2736
39. Mimura, C. S., Holbrook, S. R., and Ames, G. F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 84-88
40. Kwan, T., and Gros, P. (1998) Biochemistry 37, 3337-3350
41. Song, J., and Melera, P. W. (2001) Mol. Pharmacol. 60, 254-261
42. Loo, T. W., and Clarke, D. M. (1999) J. Biol. Chem. 274, 35388-35392
43. Hanna, M., Brault, M., Kwan, T., Kast, C., and Gros, P. (1996) Biochemistry 35, 3625-3635
44. Dey, S., Hafkemeyer, P., Pastan, I., and Gottesman, M. M. (1999) Biochemistry. 38, 6630-6639
45. Klein, I., Sarkadi, B., and Varadi, A. (1999) Biochim. Biophys. Acta 1461, 237-262
46. Loo, T. W., and Clarke, D. M. (1997) J. Biol. Chem. 272, 31945-31948
47. Loo, T. W., and Clarke, D. M. (2001) J. Biol. Chem. 276, 36877-36880
48. Loo, T. W., and Clarke, D. M. (2002) J. Biol. Chem. 277, 44332-44338
49. Currier, S. J., Kane, S. E., Willingham, M. C., Cardarelli, C. O., Pastan, I., and Gottesman, M. M. (1992) J. Biol. Chem. 267, 25153-25159
50. Loo, T. W., and Clarke, D. M. (1993) J. Biol. Chem. 268, (1996) 5-72
51. Kajiji, S., Talbot, F., Grizzuti, K., Van Dyke Phillips, V., Agresti, M., Safa, A. R., and Gros, P. (1993) Biochemistry 32, 4185-4194
52. Loo, T. W., and Clarke, D. M. (1994) Biochemistry 33, 14049-14057
53. Loo, T. W., and Clarke, D. M. (1994) J. Biol. Chem. 269, 7243-7248
54. Taguchi, Y., Morishima, M., Komano, T., and Ueda, K. (1997) FEBS Lett. 413, 142-146
55. Zhou, Y., Gottesman, M. M., and Pastan, I. (1999) Mol. Cell. Biol. 19, 1450-1459
56. Marti-Renom, M. A. Stuart, A. C., Fiser, A., Sanchez, R., Melo, F., and Sali, A. (2000) Annu. Rev. Biophys. Biomol. Struct. 29, 291-325
57. Campbell, J. D., Biggin, P. C., Baaden, M., and Sansom, M. S. (2003) Biochemistry 42, 3666-3673
58. Dunbrack, R. L., Jr, and Karplus, M. (1993) J. Mol. Biol. 230, 543-574
59. Salerno, M., Przewloka, T., Fokt, I., Priebe, W., and Garnier-Suillerot, A. (2002) Biochem. Pharmacol. 63, 1471-1479
60. Pawagi, A. B., Wang, J., Silverman, M., Reithmeier, R. A., and Deber, C. M. (1994) J. Mol. Biol. 235, 554-564
61. Kwan, T., Loughrey, H., Brault, M., Gruenheid, S., Urbatsch, I. L., Senior, A. E., and Gros, P. (2000) Mol. Pharmacol. 58, 37-47
62. Loo, T. W., and Clarke, D. M. (2000) J. Biol. Chem. 275, 19435-19438
63. Higgins, C. F., and Linton, K. J. (2001) Science 293, 1782-1784
64. Urbatsch, I. L., Gimi, K., Wilke-Mounts, S., Lerner-Marmarosh, N., Rousseau, M. E., Gros, P., and Senior, A. E. (2001) J. Biol. Chem. 276, 26980-26987
65. Loo, T. W., Bartlett, M. C., and Clarke, D. M. (2002) J. Biol. Chem. 277, 41303-41306
66. Thomas, P. J., and Hunt, J. F. (2001) Nat. Struct. Biol. 8, 920-923