Structure-activity relationship of P-glycoprotein substrates and modifiers

European Journal of Pharmaceutical Sciences

Volumn 12, Issue 1, 2000, Pages 31-40

  Seelig, Anna ^a   Landwojtowicz, Ewa ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Competitive binding; Drug transport; Hydrogen bond formation; Maximal velocity, V(max); Michaelis Menten constant, K(m); Multidrug resistance; P glycoprotein; P gp ATPase activation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMIODARONE; AMITRIPTYLINE; COLCHICINE; CYCLOSPORIN A; DAUNORUBICIN; DILTIAZEM; GLYCOPROTEIN P; GRAMICIDIN S; PROGESTERONE; PROPRANOLOL; VERAPAMIL; VINBLASTINE;

ARTICLE; CHO CELL; DRUG TRANSPORT; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROPHOBICITY; MICHAELIS MENTEN KINETICS; MULTIDRUG RESISTANCE; PARTITION COEFFICIENT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE;

ADENOSINE TRIPHOSPHATASES; AMIODARONE; AMITRIPTYLINE; ANIMALS; CHO CELLS; COLCHICINE; CRICETINAE; CYCLOSPORINE; DAUNORUBICIN; DILTIAZEM; KINETICS; MICELLES; P-GLYCOPROTEIN; PROGESTERONE; PROPRANOLOL; STRUCTURE-ACTIVITY RELATIONSHIP; VERAPAMIL; VINBLASTINE;

EID: 0033739115     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00177-9     Document Type: Article

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