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Volumn 66, Issue 5, 2004, Pages 1332-1339

Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; VALSPODAR; VERAPAMIL; ZOSUQUIDAR;

EID: 6944256675     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.002329     Document Type: Article
Times cited : (109)

References (41)
  • 1
    • 0035032440 scopus 로고    scopus 로고
    • Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus
    • Arima H, Yunomae K, Hirayama F, and Uekama K (2001) Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus. J Pharmacol Exp Ther 297:547-555.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 547-555
    • Arima, H.1    Yunomae, K.2    Hirayama, F.3    Uekama, K.4
  • 2
    • 0032421354 scopus 로고    scopus 로고
    • Functions of lipid rafts in biological membranes
    • Brown DA and London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14:111-136.
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 111-136
    • Brown, D.A.1    London, E.2
  • 3
    • 0033795486 scopus 로고    scopus 로고
    • Potential role of P-glycoprotein in affecting hepatic metabolism of drugs
    • Chiou WL, Chung SM, and Wu TC (2000) Potential role of P-glycoprotein in affecting hepatic metabolism of drugs. Pharm Res 17:903-905.
    • (2000) Pharm Res , vol.17 , pp. 903-905
    • Chiou, W.L.1    Chung, S.M.2    Wu, T.C.3
  • 4
    • 0033963650 scopus 로고    scopus 로고
    • P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries
    • Demeule M, Jodoin J, Gingras D, and Beliveau R (2000) P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries. FEBS Lett 466:219-224.
    • (2000) FEBS Lett , vol.466 , pp. 219-224
    • Demeule, M.1    Jodoin, J.2    Gingras, D.3    Beliveau, R.4
  • 5
    • 0142063411 scopus 로고    scopus 로고
    • Exclusion of a transmembrane-type peptide from ordered-lipid domains (rafts) detected by fluorescence quenching: Extension of quenching analysis to account for the effects of domain size and domain boundaries
    • Fastenberg ME, Shogomori H, Xu X, Brown DA, and London E (2003) Exclusion of a transmembrane-type peptide from ordered-lipid domains (rafts) detected by fluorescence quenching: extension of quenching analysis to account for the effects of domain size and domain boundaries. Biochemistry 42:12376-12390.
    • (2003) Biochemistry , vol.42 , pp. 12376-12390
    • Fastenberg, M.E.1    Shogomori, H.2    Xu, X.3    Brown, D.A.4    London, E.5
  • 6
    • 0036678454 scopus 로고    scopus 로고
    • The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane
    • Garrigues A, Escargueil AE, and Orlowski S (2002) The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane. Proc Natl Acad Sci USA 99:10347-10352.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10347-10352
    • Garrigues, A.1    Escargueil, A.E.2    Orlowski, S.3
  • 7
    • 3042799345 scopus 로고    scopus 로고
    • An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-glycoprotein) and CD19, causes P-glycoprotein to translocate out of lipid rafts and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line
    • Ghetie MA, Marches R, Kufert S, and Vitetta ES (2004) An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-glycoprotein) and CD19, causes P-glycoprotein to translocate out of lipid rafts and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line. Blood 104:178-183.
    • (2004) Blood , vol.104 , pp. 178-183
    • Ghetie, M.A.1    Marches, R.2    Kufert, S.3    Vitetta, E.S.4
  • 8
    • 0030774729 scopus 로고    scopus 로고
    • Cholesterol as modulator of receptor function
    • Gimpl G, Burger K, and Fahrenholz F (1997) Cholesterol as modulator of receptor function. Biochemistry 36:10959-10974.
    • (1997) Biochemistry , vol.36 , pp. 10959-10974
    • Gimpl, G.1    Burger, K.2    Fahrenholz, F.3
  • 9
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, and Bates SE (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2:48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 10
    • 0028812541 scopus 로고
    • Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor
    • Klein U, Gimpl G, and Fahrenholz F (1995) Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor. Biochemistry 34:13784-13793.
    • (1995) Biochemistry , vol.34 , pp. 13784-13793
    • Klein, U.1    Gimpl, G.2    Fahrenholz, F.3
  • 11
    • 0031691234 scopus 로고    scopus 로고
    • The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs
    • Kusuhara H, Suzuki H, and Sugiyama Y (1998) The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs. J Pharm Sci 87:1025-1040.
    • (1998) J Pharm Sci , vol.87 , pp. 1025-1040
    • Kusuhara, H.1    Suzuki, H.2    Sugiyama, Y.3
  • 12
    • 0032484149 scopus 로고    scopus 로고
    • Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells
    • Lavie Y, Fiucci G, and Liscovitch M (1998) Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells. J Biol Chem 273:32380-32383.
    • (1998) J Biol Chem , vol.273 , pp. 32380-32383
    • Lavie, Y.1    Fiucci, G.2    Liscovitch, M.3
  • 15
    • 0034327486 scopus 로고    scopus 로고
    • Multidrug resistance: A role for cholesterol efflux pathways?
    • Liscovitch M and Lavie Y (2000) Multidrug resistance: a role for cholesterol efflux pathways? Trends Biochem Sci 25:530-534.
    • (2000) Trends Biochem Sci , vol.25 , pp. 530-534
    • Liscovitch, M.1    Lavie, Y.2
  • 16
    • 0034707082 scopus 로고    scopus 로고
    • Insolubility of lipids in triton X-100: Physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts)
    • London E and Brown DA (2000) Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts). Biochim Biophys Acta 1508:182-195.
    • (2000) Biochim Biophys Acta , vol.1508 , pp. 182-195
    • London, E.1    Brown, D.A.2
  • 18
    • 0034604280 scopus 로고    scopus 로고
    • Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains
    • Luker GD, Pica CM, Kumar AS, Covey DF, and Piwnica-Worms D (2000) Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry 39:8692.
    • (2000) Biochemistry , vol.39 , pp. 8692
    • Luker, G.D.1    Pica, C.M.2    Kumar, A.S.3    Covey, D.F.4    Piwnica-Worms, D.5
  • 20
    • 0037072273 scopus 로고    scopus 로고
    • Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking
    • Pike LJ and Casey L (2002) Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking. Biochemistry 41:10315-10322.
    • (2002) Biochemistry , vol.41 , pp. 10315-10322
    • Pike, L.J.1    Casey, L.2
  • 21
    • 0036646107 scopus 로고    scopus 로고
    • Transport of phosphatidylserine via MDR1 (multidrug resistance 1) P-glycoprotein in a human gastric carcinoma cell line
    • Pohl A, Lage H, Muller P, Pomorski T, and Herrmann A (2002) Transport of phosphatidylserine via MDR1 (multidrug resistance 1) P-glycoprotein in a human gastric carcinoma cell line. Biochem J 365:259-268.
    • (2002) Biochem J , vol.365 , pp. 259-268
    • Pohl, A.1    Lage, H.2    Muller, P.3    Pomorski, T.4    Herrmann, A.5
  • 22
    • 0036733284 scopus 로고    scopus 로고
    • Caveolae: From cell biology to animal physiology
    • Razani B, Woodman SE, and Lisanti MP (2002) Caveolae: from cell biology to animal physiology. Pharmacol Rev 54:431-467.
    • (2002) Pharmacol Rev , vol.54 , pp. 431-467
    • Razani, B.1    Woodman, S.E.2    Lisanti, M.P.3
  • 23
    • 0033556083 scopus 로고    scopus 로고
    • Membrane fluidization by ether, other anesthetics and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells
    • Regev R, Assaraf YG, and Eytan GD (1999) Membrane fluidization by ether, other anesthetics and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells. Eur J Biochem 259:18-24.
    • (1999) Eur J Biochem , vol.259 , pp. 18-24
    • Regev, R.1    Assaraf, Y.G.2    Eytan, G.D.3
  • 24
    • 0033602840 scopus 로고    scopus 로고
    • The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter
    • Romsicki Y and Sharom FJ (1999) The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry 38:6887-6896.
    • (1999) Biochemistry , vol.38 , pp. 6887-6896
    • Romsicki, Y.1    Sharom, F.J.2
  • 25
    • 0035849506 scopus 로고    scopus 로고
    • Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter
    • Romsicki Y and Sharom FJ (2001) Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter. Biochemistry 40:6937-6947.
    • (2001) Biochemistry , vol.40 , pp. 6937-6947
    • Romsicki, Y.1    Sharom, F.J.2
  • 27
    • 0026625250 scopus 로고
    • Specific drug binding by purified lipid-reconstituted P-glycoprotein: Dependence on the lipid composition
    • Saeki T, Shimabuku AM, Ueda K, and Komano T (1992) Specific drug binding by purified lipid-reconstituted P-glycoprotein: dependence on the lipid composition. Biochim Biophys Acta 1107:105-110.
    • (1992) Biochim Biophys Acta , vol.1107 , pp. 105-110
    • Saeki, T.1    Shimabuku, A.M.2    Ueda, K.3    Komano, T.4
  • 28
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • Schinkel AH and Jonker JW (2003) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 55:3-29.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 30
    • 0029892497 scopus 로고    scopus 로고
    • P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    • Schinkel AH, Wagenaar E, Mol CA, and van Deemter L (1996) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Investig 97:2517-2524.
    • (1996) J Clin Investig , vol.97 , pp. 2517-2524
    • Schinkel, A.H.1    Wagenaar, E.2    Mol, C.A.3    Van Deemter, L.4
  • 31
    • 0034304851 scopus 로고    scopus 로고
    • Lipid rafts and signal transduction
    • Simons K and Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-39.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 31-39
    • Simons, K.1    Toomre, D.2
  • 32
    • 0026469337 scopus 로고
    • Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles
    • Sinicrope FA, Dudeja PK, Bissonnette BM, Safa AR, and Brasitus TA (1992) Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles. J Biol Chem 267:24995-25002.
    • (1992) J Biol Chem , vol.267 , pp. 24995-25002
    • Sinicrope, F.A.1    Dudeja, P.K.2    Bissonnette, B.M.3    Safa, A.R.4    Brasitus, T.A.5
  • 33
    • 0036279556 scopus 로고    scopus 로고
    • Alterations in membrane cholesterol that affect structure and function of caveolae
    • Smart EJ and Anderson RG (2002) Alterations in membrane cholesterol that affect structure and function of caveolae. Methods Enzymol 353:131-139.
    • (2002) Methods Enzymol , vol.353 , pp. 131-139
    • Smart, E.J.1    Anderson, R.G.2
  • 34
    • 15844401780 scopus 로고    scopus 로고
    • Expression of caveolin-3 in skeletal, cardiac and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins
    • Song KS, Scherer PE, Tang Z, Okamoto T, Li S, Chafel M, Chu C, Kohtz DS, and Lisanti MP (1996) Expression of caveolin-3 in skeletal, cardiac and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem 271:15160-15165.
    • (1996) J Biol Chem , vol.271 , pp. 15160-15165
    • Song, K.S.1    Scherer, P.E.2    Tang, Z.3    Okamoto, T.4    Li, S.5    Chafel, M.6    Chu, C.7    Kohtz, D.S.8    Lisanti, M.P.9
  • 36
    • 1642322672 scopus 로고    scopus 로고
    • Cholesterol modulates P-glycoprotein activity in human peripheral blood mononuclear cells
    • Troost J, Albermann N, Haefeli WE, and Weiss J (2004) Cholesterol modulates P-glycoprotein activity in human peripheral blood mononuclear cells. Biochem Biophys Res Commun 316:705-711.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 705-711
    • Troost, J.1    Albermann, N.2    Haefeli, W.E.3    Weiss, J.4
  • 37
    • 0032101275 scopus 로고    scopus 로고
    • The pharmacological role of P-glycoprotein in the intestinal epithelium
    • van Asperen J, van Tellingen O, and Beijnen JH (1998) The pharmacological role of P-glycoprotein in the intestinal epithelium. Pharmacol Res 37:429-435.
    • (1998) Pharmacol Res , vol.37 , pp. 429-435
    • Van Asperen, J.1    Van Tellingen, O.2    Beijnen, J.H.3
  • 38
    • 0037012905 scopus 로고    scopus 로고
    • Cell biology. The different hues of lipid rafts
    • van Meer G (2002) Cell biology. The different hues of lipid rafts. Science (Wash DC) 296:855-857.
    • (2002) Science (Wash DC) , vol.296 , pp. 855-857
    • Van Meer, G.1
  • 41
    • 0037432169 scopus 로고    scopus 로고
    • Involvement of cholesterol in the inhibitory effect of dimethyl-beta-cyclodextrin on P-glycoprotein and MRP2 function in Caco-2 cells
    • Yunomae K, Arima H, Hirayama F, and Uekama K (2003) Involvement of cholesterol in the inhibitory effect of dimethyl-beta-cyclodextrin on P-glycoprotein and MRP2 function in Caco-2 cells. FEBS Lett 536:225-231.
    • (2003) FEBS Lett , vol.536 , pp. 225-231
    • Yunomae, K.1    Arima, H.2    Hirayama, F.3    Uekama, K.4


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