Effects of geographical origin, varietal and farming system on the chemical composition and functional properties of purple grape juices: A review

Trends in Food Science and Technology

Volumn 52, Issue , 2016, Pages 31-48

  Granato, Daniel ^a,b   de Magalhães Carrapeiro, Mariana ^c   Fogliano, Vincenzo ^b   van Ruth, Saskia M ^b  

^a STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c University Center Estácio do Ceará   (Brazil)

Author keywords

Antioxidant activity; Bioactivity; Biodynamic farming; Organic viticulture; Phenolic compounds; Vitis labrusca; Vitis vinifera

Indexed keywords

ANTIOXIDANTS; BIOACTIVITY; FRUIT JUICES; PHENOLS;

ANTI-OXIDANT ACTIVITIES; BIODYNAMIC FARMING; ORGANIC VITICULTURE; PHENOLIC COMPOUNDS; VITIS LABRUSCA; VITIS VINIFERA;

CHEMICAL COMPOUNDS;

EID: 85032069294     PISSN: 09242244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tifs.2016.03.013     Document Type: Review

References (156)

1. Abe L.T., Da Mota R.V., Lajolo F.M., Genovese M.I. Phenolic compounds and antioxidant activity of Vitis labrusca and Vitis vinifera cultivars. Ciencia e Tecnologia de Alimentos 2007, 27(2):394-400.
2. Akçay Y.D., Yildirim H.K., Güvenç U., Sözmen E.Y. The effects of consumption of organic and nonorganic red wine on low-density lipoprotein oxidation and antioxidant capacity in humans. Nutrition Research 2004, 24(7):541-554.
3. Alaei H., Siahmard Z., Reisi P. Red grape juice and Alzheimer's disease. Diet and nutrition in dementia and cognitive decline 2015, 935-942. Academic Press. 1st ed. C.R. Martin, V.R. Preedy (Eds.).
4. Alam M.D., Bristi N.J., Rafiquzzman M. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharmaceutical Journal 2013, 21:143-152.
5. Albers A.R., Varghese S., Vitseva O., Vita J.A., Freedman J.E. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arteriosclerosis Thrombosis and Vascular Biology 2004, 24:e179-e180.
6. Andersen P.C., Crocker T.E., Breman J. The Muscadine grape 2003, Available at, Access 15.03.15. http://edis.ifas.ufl.edu/pdffiles/HS/HS10000.pdf.
7. Andrade E.R., Cruz I.B.M., Andrade V.V.R., Piccoli J.C.E., González-Gallego J., Barrio J.P., et al. Evaluation of the potential protective effects of ad libitum black grape juice against liver oxidative damage in whole-body acute X-irradiated rats. Food and Chemical Toxicology 2011, 49(4):1026-1032.
8. Apak R., Gorinstein S., Böhm V., Schaich K.M., Özyürek M., Güçlü K. Methods of measurement and evaluation of natural antioxidant capacity/activity (IUPAC Technical Report). Pure and Applied Chemistry 2013, 85(5):957-998.
9. Apak R., Özyürek M., Güçlü K., Çapanoglu E. Antioxidant activity/capacity measurement. 2. Hydrogen atom transfer (HAT)-based, mixed-mode (electron transfer (ET)/HAT), and lipid peroxidation assays. Journal of Agricultural and Food Chemistry 2016, 64(5):1028-1045.
10. Banini A.E., Boyd L.C., Allen J.C., Allen H.G., Sauls D.L. Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Nutrition 2006, 22(11-12):1137-1145.
11. Borrás E., Ferré J., Boqué R., Mestres M., Aceña L., Busto O. Data fusion methodologies for food and beverage authentication and quality assessment - a review. Analytica Chimica Acta 2015, 891:1-14.
12. Brandt K., Mølgaard J.P. Organic agriculture: does it enhance or reduce the nutritional value of plant foods?. Journal of the Science of Food and Agriculture 2001, 81(9):924-931.
13. o 19, de 19 de junho de 2013, Available at, Access 10.02.15. http://www.sucodeuvadobrasil.com.br/legislacao/INSTRUCAO_NORMATIVA_No_19_DE_19_DE_JUNHO_DE_2013___pic_bebidas_n_alcoolicas.pdf.
14. Brouillard R., Chassaing S., Fougerousse A. Why are grape/fresh wine anthocyanins so simple and why is it that red wine color lasts so long?. Phytochemistry 2003, 64(7):1179-1186.
15. Buchner I., Medeiros N., Lacerda D.S., Normann C.A.B.M., Gemelli T., Rigon P., et al. Hepatoprotective and antioxidant potential of organic and conventional grape juices in rats fed a high-fat diet. Antioxidants 2014, 3:323-338.
16. Bunea C.I., Pop N., Babes A.C., Matea C., Dulf F.V., Bunea A. Carotenoids, total polyphenols and antioxidant activity of grapes (Vitis vinifera) cultivated in organic and conventional systems. Chemistry Central Journal 2012, 6:1-9.
17. Burin V.M., Falcão L.D., Gonzaga L.V., Fett R., Rosier J.P., Bordignon-Luiz M.T. Colour, phenolic content and antioxidant activity of grape juice. Ciencia e Tecnologia de Alimentos 2010, 30(4):1027-1032.
18. Burin V.M., Ferreira-Lima N.E., Panceri C.P., Bordignon-Luiz M.T. Bioactive compounds and antioxidant activity of Vitis vinifera and Vitis labrusca grapes: evaluation of different extraction methods. Microchemical Journal 2014, 114:155-163.
19. Capuano E., Boerringter-Eenling R., van der Veer G., van Ruth S.M. Analytical authentication of organic products: an overview of markers. Journal of the Science of Food and Agriculture 2013, 93(1):12-28.
20. Carbonell-Capella J.M., Buniowska M., Barba F.J., Esteve M.J., Frígola A. Analytical methods for determining bioavailability and bioaccessibility of bioactive compounds from fruits and vegetables: a review. Comprehensive Reviews in Food Science and Food Safety 2014, 13(2):155-171.
21. Chou E.J., Keevil J.G., Aeschlimann S., Wiebe D.A., Folts J.D., Stein J.H. Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. American Journal of Cardiology 2001, 88(5):553-555.
22. Chuang C.C., Bumrungpert A., Kennedy A., Overman A., West T., Dawson B., et al. Grape powder extract attenuates tumor necrosis factor α-mediated inflammation and insulin resistance in primary cultures of human adipocytes. The Journal of Nutritional Biochemistry 2011, 22(1):89-94.
23. Coetzee P.P., van Jaarsveld F.P., Vanhaecke F. Intraregional classification of wine via ICP-MS elemental fingerprinting. Food Chemistry 2014, 164:485-492.
24. Codex Alimentarius. CODEX general standard for fruit juices and nectars (CODEX STAN 247-2005). Available at. http://www.codexalimentarius.org/input/download/standards/10154/CXS_247e.pdf.
25. Dani C., Oliboni L.S., Umezu F.M., Pasquali M.A.B., Salvador M., Moreira J.C.F., et al. Antioxidant and antigenotoxic activities of purple grape juice-organic and conventional-in adult rats. Journal of Medicinal Food 2009, 12(5):1111-1118.
26. Dani C., Oliboni L.S., Vanderlinde R., Bonatto D., Salvador M., Henriques J.A.P. Phenolic content and antioxidant activities of white and purple juices manufactured with organically or conventionally-produced grapes. Food Chemical Toxicology 2007, 45:2574-2580.
27. Daniells, S. US organic food market to grow 14% from 2013-18. Available at. Accessed 14.03.15. http://www.foodnavigator-usa.com/Markets/US-organic-food-market-to-grow-14-from-2013-18.
28. Dávalos A., Bartolomé B., Gómez-Cordovés C. Antioxidant properties of commercial grape juice and vinegars. Food Chemistry 2005, 93:325-330.
29. Dávalos A., Fernández-Hernando C., Cerrato F., Martínez-Botas J., Gómez-Coronado D., Gómez-Cordovés C., et al. Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. Journal of Nutrition 2006, 136:1766-1773.
30. Della Corte C.L., Carvalho N.R., Amaral G.P., Puntel G.O., Silva L.F.A., Retamoso L.T., et al. Antioxidant effect of organic purple grape juice on exhaustive exercise. Applied Physiology, Nutrition, and Metabolism 2013, 38(5):558-565.
31. Demeter International eV. Production standards. For the use of demeter, biodynamic and related trademarks 2012, Available at, Accessed 19.02.15). http://www.demeter.net/certification/standards.
32. Dillenburg D.R., Mostarda C., Moraes-Silva I.C., Ferreira D., Bós D.S.G., Duarte A.A.M., et al. Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats. Autonomic Neuroscience 2013, 179(1-2):9-13.
33. EC Council Regulation (EC) No 834/2007 of 28 June 2007 on organic production and labelling of organic products and repealing Regulation (EEC) No 2092/91. Official Journal of the European Union, L 2007, 189:1-23.
34. EC Commission implementing regulation (EU) No 203/2012 of 8 March 2012 amending Regulation (EC) No 889/2008 laying down detailed rules for the implementation of Council Regulation (EC) No 834/2007, as regards detailed rules on organic wine. Official Journal of the European Union, L 2012, 71:42-47.
35. El-Kassas F.B., Ali A.M., Mostafa S.E. Phenolic compounds as antioxidants of some products manufactured from two cultivated Egyptian varieties of seedless grapes. Annals of Agricultural Sciences 2014, 59(2):195-199.
36. Eur-Lex. Fruit juices and similar products - Council directive 2001/112/EC. Available at. http://eur-lex.europa.eu/legal-content/EN/TXT/?uri=URISERV:l21132.
37. European Commission Proposal for a regulation of the European Parliament and of the Council on organic production and labeling of organic products, amending Regulation (EU) No XXX/XXX of the European Parliament and of the Council (Official controls Regulation) and repealing Council regulation (EC) No 834/2007 2014, European Commission, Brussels.
38. European Commission Action plan for the future of organic production in the European union 2014, European Commission, Brussels.
39. European Commission Organics: Commission proposal for more and better. Press release of March 25, 2014 2014, Website of the European Commission, Brussels.
40. European Fruit Juice Association Market report 2012, Available at, Access on 12.03.14. http://www.aijn.org/pages/main/file.handler?f=AIJNMarketReport2012.pdf.
41. European Fruit Juice Association (AIJN) Market report 2013, Available at, Access on 10.02.15. http://www.aijn.org/pages/main/facts-figures.html.
42. Fagundes Assumpcao C.F., Hermes V.S., Bortolin R.C., Moreira J.C.F., Manfroi V., Jablonski A., et al. Carotenoid content and antioxidant activity of organic and conventional grape juice processing waste. Current Bioactive Compounds 2015, 11(4):249-255.
43. Folts J.D. Antithrombotic potential of grape juice and red wine for preventing heart attacks. Pharmaceutical Biology 1998, 36(Supplement 1):21-27.
44. Food and Agriculture Organization (FAO).2011 Production of grapes. Available at. Access on 12.03.14. http://faostat.fao.org/site/339/default.aspx.
45. Forman H.J., Davies K.J.A., Ursini F. How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radical Biology and Medicine 2014, 66:24-35.
46. Fragopoulou E., Antonopoulou S., Nomikos T., Demopoulos C.A. Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. Biochimica et Biophysica Acta 2003, 1632:90-99.
47. Freedman J.E., Parker C., Li L., Perlman J.A., Frei B., Ivanov V., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001, 103(23):2792-2798.
48. Garaguso I., Nardini M. Polyphenols content, phenolics profile and antioxidant activity of organic red wines produced without sulfur dioxide/sulfites addition in comparison to conventional red wines. Food Chemistry 2015, 179:336-342.
49. Garde-Cerdán T., Arias-Gil M., Marsellés-Fontanet R., Ancín-Azpilicueta C., Martín-Belloso O. Effects of thermal and non-thermal processing treatments on fatty acids and free amino acids of grape juice. Food Chemistry 2007, 18:473-479.
50. Garrido J., Borges F. Wine and grape polyphenols - A chemical perspective. Food Research International 2013, 54(2):1844-1858.
51. Geana E.I., Marinescu A., Iordache A.M., Sandru C., Ionete R.E., Bala C. Differentiation of Romanian wines on geographical origin and wine variety by elemental composition and phenolic components. Food Analytical Methods 2014, 7:2064-2074.
52. Genova G., Tosetti R., Tonutti P. Berry ripening, pre-processing and thermal treatments affect the phenolic composition and antioxidant capacity of grape (Vitis vinifera L.) juice. Journal of the Science of Food and Agriculture 2016, 96(2):664-671.
53. Genovese M.I., Hassimotto N.M.A., Lajolo F.M. Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. Nutrition Research 2008, 28:198-207.
54. Granato D., Katayama F., Castro I.A. Phenolic composition of South American red wines classified according to their antioxidant activity, retail price and sensory quality. Food Chemistry 2011, 129:366-373.
55. Granato D., Koot A., Schnitzler E., van Ruth S.M. Authentication of geographical origin and farming system of grape juices by phenolic compounds and antioxidant activity using chemometrics. Journal of Food Science 2015, 80:C584-C593.
56. Granato D., Koot A., van Ruth S.M. Geographical provenancing of purple grape juices from different farming systems by proton transfer reaction mass spectrometry using supervised statistical techniques. Journal of the Science of Food and Agriculture 2015, 95(13):2668-2677.
57. Granato D., Margraf T., Brotzakis I., Capuano E., van Ruth S.M. Characterization of conventional, biodynamic, and organic purple grape juices by chemical markers, antioxidant capacity, and instrumental taste profile. Journal of Food Science 2015, 80:C55-C65.
58. Granese T., Cardinale F., Cozzolino A., Pepe S., Ombra M.N., Nazzaro F., et al. Variation of polyphenols, anthocyanins and antioxidant power in the strawberry grape (Vitis labrusca) after simulated gastro-intestinal transit and evaluation of in vitro antimicrobial activity. Food and Nutrition Sciences 2014, 5(1):1-6.
59. Greene, C. Growth patterns in the US organic industry. Available at. Access 14.03.15.2013. http://www.ers.usda.gov/amber-waves/2013-october/growth-patterns-in-the-us-organic-industry.aspx#.VQSV_uFUUwQ.
60. Greene C., Kremen A. U.S. Organic farming in 2000-2001: adoption of certified systems. USDA Agriculture Informative Bulletin 2003, 780:1-50.
61. Hallmann E., Rembiałkowska E. Characterisation of antioxidant compounds in sweet bell pepper (Capsicum annuum L.) under organic and conventional growing systems. Journal of the Science of Food and Agriculture 2012, 92(12):2409-2415.
62. Hernandz-Orte P., Ibarz M.J., Cacho J., Ferreira V. Amino acid determination in grape juices and wines by HPLC using a modification of the 6-aminoquinolyl-n -hydroxysuccinimidyl carbamate (AQC) method. Chromatographia 2003, 58(1-2):29-35.
63. Hollman P.C.H. Evidence for health benefits of plant phenols: local or systemic effects?. Journal of the Science of Food and Agriculture 2001, 81(9):842-852.
64. Hopfer H., Nelson J., Collins T.S., Heymann H., Ebeler S.E. The combined impact of vineyard origin and processing winery on the elemental profile of red wines. Food Chemistry 2015, 172:486-496.
65. Huang K.S., Lin M. Oligostilbenes from the roots of Vitis amurensis. Journal of Asian Natural Products Research 1999, 2(1):21-28.
66. Huber B., Schmid O., Mannigel C. Standards and regulations. IFOAM: The world of organic agriculture. Statistics & emerging trends 2015 2015, Available at: International Federation of Organic Agriculture Movements.
67. Hugh J., Robinson J. The world Atlas of wine 2013, 400. Mitchell Beazley, England. 7th ed.
68. Ibravin. (2014). Instituto Brasileiro do Vinho. Estatísticas. Available at:. Access on 08.02.14. http://www.ibravin.org.br/dados-estatisticos.
69. Iyer M.M., Sacks G.L., Padilla-Zakour O.I. Impact of harvesting and processing conditions on green leaf volatile development and phenolics in Concord grape juice. Journal of Food Science 2010, 75(3):C297-C304.
70. Jayani R.S., Saxena S., Gupta R. Microbial pectinolytic enzymes: a review. Process Biochemistry 2005, 40(9):2931-2944.
71. Jung K.J., Wallig M.A., Singletary K.W. Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Letters 2006, 233:279-288.
72. Kahl J., Baars T., Bügel S., Busscher N., Huber M., Kusche D., et al. Organic food quality: a framework for concept, definition and evaluation from the European perspective. Journal of the Science of Food and Agriculture 2012, 92(14):2760-2765.
73. Karapinar M., Sengun I.Y. Antimicrobial effect of koruk (unripe grape - Vitis vinifera) juice against Salmonella typhimurium on salad vegetables. Food Control 2007, 18(6):702-706.
74. Koepf H., Schaumann W., Haccius M. Agricoltura Biodinamica: Antroposofica Editrice 2001.
75. Kokornaczyk M.O., Parpinello G.P., Versari A., Rombolá A.D., Betti L. Qualitative discrimination between organic and biodynamic Sangiovese red wines using droplet evaporation approach. Analytical Methods 2014, 6:7484-7488.
76. Krikorian R., Nash T.A., Shidler M.D., Shukitt-Hale B., Joseph J.A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Brazilian Journal of Nutrition 2010, 103(5):730-734.
77. Kuepper, G., & Gegner, L. Organic crop production overview. Available at:. Access on 09.10.14.2004. https://attra.ncat.org/attra-pub/summaries/summary.php?pub=66.
78. Lachman J., Sulc M., Schilla M. Comparison of the total antioxidant status of Bohemian wines during the wine-making process. Food Chemistry 2007, 103:802-807.
79. Lacombe P., Thomash M.R. Historical origins and genetic diversity of wine grapes. Trends in Genetics 2006, 22(9):511-519.
80. Leblanc M.R., Johnson C.E., Wilson P.W. Influence of pressing method on juice stilbene content in Muscadine and Bunch grapes. Journal of Food Science 2008, 73(4):H58-H62.
81. Lima M.S., Dutra M.C.P., Toaldo I.M., Corrêa L.C., Pereira G.E., Oliveira D., et al. Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. Food Chemistry 2015, 188:384-392.
82. Lima M., Silani I., Toaldo I.M., Corrêa L., Biasoto A., Pereira G., et al. Phenolic compounds, organic acids, and antioxidant activity of grape juices produced from new Brazilian varieties planted in the Northeast region of Brazil. Food Chemistry 2014, 161:94-103.
83. López-Alarcón C., Denicola A. Evaluating the antioxidant capacity of natural products. A review on chemical and cellular-based assays. Analytica Chimica Acta 2013, 763:1-10.
84. Luthria D., Singh A.P., Wilson T., Vorsa N., Banuelos G.S., Vinyard B.T. Influence of conventional and organic agricultural practices on the phenolic content in eggplant pulp: plant-to-plant variation. Food Chemistry 2010, 121:406-411.
85. Lutz M., Jorquera K., Cancino B., Ruby R., Henriquez C. Phenolics and antioxidant capacity of table grape (Vitis vinifera L.) cultivars grown in Chile. Journal of Food Science 2011, 76(7):C1088-C1093.
86. Macedo L.F.L., Rogero M.M., Guimarães J.P., Granato D., Lobato L.P., Castro I.A. Effect of red wines with different in vitro antioxidant activity on oxidative stress of high-fat diet rats. Food Chemistry 2013, 137:122-129.
87. Machado M.M., Montagner G.F.F.S., Bolignon A., Athayde M.L., Rocha M.I.U.M., Lera J.P.B., et al. Determination of polyphenol contents and antioxidant capacity of no-alcoholic red grape products (Vitis labrusca) from conventional and organic crops. Química Nova 2011, 34(5):798-803.
88. Malacrida C.R., Motta S. Compostos fenólicos totais e antocianinas em suco de uva. Ciencia e Tecnologia de Alimentos 2005, 25:659-664.
89. Marchi P., Paiotti A.P.R., Neto R.A., Oshima C.T.F., Ribeiro D.A. Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis. Environmental Toxicology and Pharmacology 2014, 37(2):819-827.
90. Margalef M., Guerrero L., Pons Z., Bravo F.I., Arola L., Muguerza B., et al. A dose-response study of the bioavailability of grape seed proanthocyanidin in rat and lipid-lowering effects of generated metabolites in HepG2 cells. Food Research International 2014, 64:500-507.
91. Margraf T., Karnopp A.R., Rosso N.D., Granato D. Comparison between Folin-Ciocalteu and Prussian Blue assays to estimate the total phenolic content of juices and teas using 96-well microplates. Journal of Food Science 2015, 80(11):C2397-C2403.
92. Margraf T., Santos E.N.T., Andrade E.F., van Ruth S.M., Granato D. Effects of geographical origin, variety and farming system on the chemical markers and in vitro antioxidant capacity of Brazilian purple grape juices. Food Research International 2016, 82:145-155.
93. Martins N., Barros L., Ferreira I.C.F.R. In vivo antioxidant activity of phenolic compounds: facts and gaps. Trends in Food Science & Technology 2016, 48:1-12.
94. Mondavi R.G., McGovern P.E. Ancient wine: The search for the origins of viniculture 2007, 392. Princeton University Press, Princeton.
95. Monrad J.K., Suárez M., Motilva M.J., King J.W., Srinivas K., Howard L.R. Extraction of anthocyanins and flavan-3-ols from red grape pomace continuously by coupling hot water extraction with a modified expeller. Food Research International 2014, 65:77-87.
96. Moreno-Montoro M., Olalla-Herrera M., Gimenez-Martinez R., Navarro-Alarcon M., Rufián-Henares J.A. Phenolic compounds and antioxidant activity of Spanish commercial grape juices. Journal of Food Composition and Analysis 2015, 38:19-26.
97. Morris J.R. Factors influencing grape juice quality. Hort Technology 1998, 8(4):471-478.
98. Morris J.R., Striegler K. Grape juice: factors that influence quality, processing technology, and economics. Processing fruits: Science and technology 1996, 585. CRC Press, Boca Raton, FL. 2nd ed. D.M. Barrett, L. Somogyi, H. Ramaswamy (Eds.).
99. Munõz-Espada A.C., Wood K.V., Bordelon B., Watkins B.A. Anthocyanin quantification and radical scavenging capacity of concord, Norton, and Marechal Foch grapes and wines. Journal of Agricultural and Food Chemistry 2004, 52:6779-6786.
100. Nan L., Liu L., Zhao X., Qiu S., Wang H., Li H. Effect of alternative new pruning system and harvesting times on aroma compounds of young wines from Ecolly (Vitis vinifera) in a new grape growing region of the Weibei Plateau in China. Scientia Horticulturae 2013, 162:181-187.
101. Natividade M.M.P., Corrêa L.C., Souza S.V.C., Pereira G.E., Lima L.C.O. Simultaneous analysis of 25 phenolic compounds in grape juice for HPLC: method validation and characterization of São Francisco Valley samples. Microchemical Journal 2013, 110:665-674.
102. OIV, Office International de la Vigne et du Vin Recueil des Méthodes Internationales d'Analyse des Vins et des MoÛts 1990, Office International de la Vigne et du Vin, Paris.
103. Oliboni L.S., Vanderlinde R., Bonatto D., Salvador M., Henriques J.A.P. Phenolic content and antioxidant activities of white and purple juices manufactures with organically or conventionally-produced grapes. Food and Chemical and Toxicology 2007, 45:2574-2580.
104. Oliveira C.C., Calado V.M.A., Ares G., Granato D. Statistical approaches to assess the association between phenolic compounds and the in vitro antioxidant activity of Camellia sinensis and Ilex paraguariensis teas. Critical Reviews in Food Science and Nutrition 2015, 55(10):1456-1473.
105. Organics Brasil. Available at. Access 14.03.15. http://www.organicsbrasil.org/dnfile/rdvutgnenb3wbt9yiima/pdf/downloads/0/arquivo-rdvutgnenb3wbt9yiima.pdf.
106. Organic Trade Association. Market analysis. Available at. Access 14.03.15. https://ota.com/what-ota-does/market-analysis.
107. Osman H.E., Maalej N., Shanmuganayagam D., Folts J.D. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. Journal of Nutrition 1998, 128(12):2307-2312.
108. O'Byrne D.J., Devaraj S., Grundy S.M., Jialal I. Comparison of the antioxidant effects of Concord grape juice flavonoids α-tocopherol on markers of oxidative stress in healthy adults. American Journal of Clinical Nutrition 2002, 76(6):1367-1374.
109. Paranjpe S.S., Ferruzzi M., Morgan M.T. Effect of a flash vacuum expansion process on grape juice yield and quality. LWT - Food Science and Technology 2012, 48(2):147-155.
110. Park Y.K., Park E., Kim J.S., Kang M.H. Daily grape juice consumption reduces oxidative DNA damage and plasma free radical levels in healthy Koreans. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2003, 529(1-2):77-86.
111. Parpinello G.P., Rombolá A.D., Simoni M., Versari A. Chemical and sensory characterisation of Sangiovese red wines: comparison between biodynamic and organic management. Food Chemistry 2015, 167:145-152.
112. Pereira G.E., Lima L.C.O., Regina M.A., Rosier J.P., Ferraz V., Mourão M. Potential evaluation of five American cultivars for grape juices in the south of Minas Gerais state. Ciencia e Agrotecnologia 2008, 32(5):1531-1537.
113. Pisano P.L., Silva M.F., Olivieri A.C. Anthocyanins as markers for the classification of Argentinean wines according to botanical and geographical origin. Chemometric modeling of liquid chromatography-mass spectrometry data. Food Chemistry 2015, 175:174-180.
114. Rathburn I.M., Morris J.R. Evaluation of varietal grape juice - influence of processing method, sugar and acid adjustment, and carbonation. Journal of Food Quality 1990, 13(6):395-409.
115. Rhodes P.L., Mitchell J.W., Wilson M.W., Melton L.D. Antilisterial activity of grape juice and grape extracts derived from Vitis vinifera variety Ribier. International Journal of Food Microbiology 2006, 107(3):281-286.
116. Robinson J. Vines, Grapes and wines: the wine drinker's guide to grape varieties 2003, 280. Mitchell Beazley, England.
117. Rodrigues A.D., Scheffel T.B., Scola G., Santos M.T., Fank B., Dani C., et al. Purple grape juices prevent pentylenetetrazol-induced oxidative damage in the liver and serum of Wistar rats. Nutrition Research 2013, 33(2):120-125.
118. Rodrigues A.D., Scheffel T.B., Scola G., Santos M.T., Fank B., Freitas S.C.V., et al. Neuroprotective and anticonvulsant effects of organic and conventional purple grape juices on seizures in Wistar rats induced by pentylenetetrazole. Neurochemistry International 2012, 60:799-805.
119. Rowe C.A., Nantz M.P., Nieves C., West R.L., Percival S.S. Regular consumption of Concord grape juice benefits human immunity. Journal of Medicinal Food 2011, 14(1-2):69-78.
120. Schaich K.M., Tian X., Xie J. Hurdles and pitfalls in measuring antioxidant efficacy: a critical evaluation of ABTS, DPPH, and ORAC assays. Journal of Functional Foods 2015, 14:111-125.
121. Sengul H., Surek E., Nilufer-Erdil D. Investigating the effects of food matrix and food components on bioaccessibility of pomegranate (Punica granatum) phenolics and anthocyanins using an in vitro gastrointestinal digestion model. Food Research International 2014, 62:1069-1079.
122. Seufert V., Ramankutty N., Foley J.A. Comparing the yields of organic and conventional agriculture. Nature 2012, 485:229-232.
123. Shahidi F., Naczk M. Phenolics in food and nutraceticals 2004, 365. CRC Press, New York.
124. Shahidi F., Zhong Y. Measurement of antioxidant activity. Journal of Functional Foods 2015, 18:757-781.
125. Shanmuganayagam D., Warner T.F., Krueger C.G., Reed J.D., Folts J.D. Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits. Atherosclerosis 2007, 190(1):135-142.
126. Siahmard Z., Alaei H., Reisi P., Pilehvarian A.A. The effect of red grape juice on Alzheimer's disease in rats. Advances in Biomedical Research 2012, 1(4):1-4.
127. Silva J.K., Cazarin C.B.B., Correa L.C., Batista A.G., Furlan C.P.B., Biasoto A.C.T., et al. Bioactive compounds of juices from two Brazilian grape cultivars. Journal of the Science of Food and Agriculture 2016, 96(6):1990-1996.
128. Snyder A.B., Sweeney C.F., Rodriguez-Saona L.E., Giusti M.M. Rapid authentication of concord juice concentration in a grape juice blend using Fourier-Transform infrared spectroscopy and chemometric analysis. Food Chemistry 2014, 147:295-301.
129. Stalmach A., Edwards C.A., Wightman J.D., Crozier A. Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. Journal of Agricultural and Food Chemistry 2011, 59(17):9512-9522.
130. Stein J.H., Keevil J.G., Wiebe D.A., Aeschlimann S., Folts J.D. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999, 100(10):1050-1055.
131. Steiner R., Gardner M. Spiritual foundations for the renewal of agriculture: A course of lectures held at Koberwitz, Silesia, June 7 to June 16, 1924 1993, Bio-Dynamic Farming and Gardening Association, Kimberton, Pennsylvania.
132. Sugiyama A., Saitoh M., Takahara A., Satoh Y., Hashimoto K. Acute cardiovascular effects of a new beverage made of wine vinegar and grape juice, assessed using an in vivo rat. Nutrition Research 2003, 23(9):1291-1296.
133. Tabela Brasileira de Composição de Alimentos (TACO) Brazilian food composition table 2009, Available at, Access on 28.06.15. http://www.unicamp.br/nepa/taco/contar/taco_4_edicao_ampliada_e_revisada.
134. Tamborra P., Esti M. Authenticity markers in Aglianico, Uva di Troia, Negroamaro and Primitivo grapes. Analytica Chimica Acta 2010, 660(1-2):221-226.
135. Tarko T., Duda-Chodak A., Sroka P., Satora P., Michalik J. Transformations of phenolic compounds in an in vitro model simulating the human alimentary tract. Food Technology and Biotechnology 2009, 47(4):456-463.
136. Tassoni A., Tango N., Ferri M. Comparison of biogenic amine and polyphenol profiles of grape berries and wines obtained following conventional, organic and biodynamic agricultural and oenological practices. Food Chemistry 2013, 139:405-413.
137. Technical University of Denmark (DTU Food) Danish food composition table 2011, Available at, Access on 28.06.15. http://www.foodcomp.dk/v7/fcdb_details.asp?FoodId=1087.
138. Teixeira A., Eiras-Dias J., Castellarin S.D., Gerós H. Berry phenolics of grapevine under challenging environments. International Journal of Molecular Sciences 2013, 14(9):18711-18739.
139. Toaldo I.M., Cruz F.A., Alves T.L., Gois J.S., Borges D.L.G., Cunha H.P., et al. Bioactive potential of Vitis labrusca L. grape juices from the Southern Region of Brazil: phenolic and elemental composition and effect on lipid peroxidation in healthy subjects. Food Chemistry 2015, 173:527-535.
140. Tres A., O'Neill R., van Ruth S.M. Fingerprinting of fatty acid composition for the verification of the identity of organic eggs. Lipid Technology 2011, 23(2):40-42.
141. Vallverdú-Queralt A., Medina-Remón A., Casals-Ribes I., Lamuela-Raventos R.M. Is there any difference between the phenolic content of organic and conventional tomato juices?. Food Chemistry 2012, 130(1):222-227.
142. Vardin H., Tay A., Ozen B., Mauer L. Authentication of pomegranate juice concentrate using FTIR spectroscopy and chemometrics. Food Chemistry 2008, 108(2):742-748.
143. Versari A., Laurie V.F., Ricci A., Laghi L., Parpinello G.P. Progress in authentication, typification and traceability of grapes and wines by chemometric approaches. Food Research International 2014, 60:2-18.
144. Vilas Boas A.C., Henrique P.C., Lima L.C.O., Neto A.D. Antioxidant activity, anthocyanins and organic acids content of grape juices produced in Southwest of Minas Gerais, Brazil. Ciencia e Agrotecnologia 2014, 38(5):480-486.
145. Vinson J.A., Teufel K., Wu N. Red wine, dealcoholized red wine, and especially grape juice, inhibit atheroclerosis in a hamster model. Atherosclerosis 2001, 156:67-72.
146. Wahlberg I., Eklund A.M. Carotenoids: biosynthesis and metabolism. Pfander Basel Boston 1998, 195-216. Birkäuser Verlag. Degraded carotenoids, Berlin. G. Britton, S. Liaaen-Jensen (Eds.).
147. Wightman J.D., Heuberger R.A. Effect of grape and other berries on cardiovascular health. Journal of the Science of Food and Agriculture 2015, 95(8):1584-1597.
148. Willer, H., & Lernoud, J. The European market for organic food. Available at. Access 14.03.15.2014. http://www.biofach.fibl.org/fileadmin/documents/de/news/2014/willer-schaack-2014-biofach-europe-market.pdf.
149. Willer H., Meredith S. Organic farming in Europe. IFOAM: The world of organic agriculture. Statistics & emerging trends 2015 2015, International Federation of Organic Agriculture Movements, Available at.
150. Xiang L., Xiao L., Wang Y., Li H., Huang Z. Health benefits of wine: don't expect resveratrol too much. Food Chemistry 2014, 156:258-263.
151. Yoon J.H., Kim K., Lee D.S. Chemometric aspects of sugar profiles in fruit juices using HPLC and GC. Bulletin of the Korean Chemistry Society 1997, 18(7):695-702.
152. Yuan F., Qian M.C. Development of C13-norisoprenoids, carotenoids and other volatile compounds in Vitis vinifera L. Cv. Pinot Noir grapes. Food Chemistry 2016, 192:633-641.
153. Zhang P., Barlow S., Krstic M., Herderich M., Fuentes S., Howell K. Within-vineyard, within-vine, and within-bunch variability of the rotundone concentration in berries of Vitis vinifera L. cv. Shiraz. Journal of Agricultural and Food Chemistry 2015, 63(17):4276-4283.
154. Zhao M., Liu X., Luo Y., Guo H., Hu X., Chen F. Evaluation of protective effect of freeze-dried strawberry, grape, and blueberry powder on acrylamide toxicity in mice. Journal of Food Science 2015, 80(4):H869-H874.
155. Zhou K., Raffoul J.J. Potential anticancer properties of grape antioxidants - a review. Journal of Oncology 2012, 2012:1-8.
156. ZibaeeNezhad M.J., Mohammadi E., Beigi M.A.B., Mirzamohammadi F., Salehi O. The effects of unripe grape juice on lipid profile improvement. Cholesterol 2012, 2012:1-3.