Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro

Journal of Nutrition

Volumn 136, Issue 7, 2006, Pages 1766-1773

  Dávalos, Alberto ^a   Fernández Hernando, Carlos ^a,d   Cerrato, Francisca ^a   Martínez Botas, Javier ^a   Gómez Coronado, Diego ^a   Gómez Cordovés, Carmen ^b   Lasunción, Miguel A ^a,c  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b INSTITUTO DE FERMENTACIONES INDUSTRIALES CSIC   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesterol trafficking; LDL cholesterol; LDL receptor; Red grape juice polyphenols

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN B; BINDING PROTEIN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CYTOCHROME P450; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTOR; POLYPHENOL DERIVATIVE; PROTEIN ABCG5; RED GRAPE JUICE POLYPHENOL DERIVATIVE; S 58035; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; FLUORESCENCE MICROSCOPE; GENE EXPRESSION; GRAPE JUICE; HEART PROTECTION; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; REAL TIME POLYMERASE CHAIN REACTION; RED GRAPE JUICE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

VITIS SP.;

EID: 33745652051     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.7.1766     Document Type: Article

References (48)

1. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary artery heart disease. Lancet. 1992;339:1523-6.
2. Rimm E, Giovannucci E, Willet W, Coldits G. Acheriori A, Rosner B, Stampfer M. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet. 1991;338:464-8.
3. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 1993;342:1007-11.
4. Folts JD. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Biol. 2002;505:95-111.
5. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991;88:1785-92.
6. De Whalley CV, Rankin SM, Hoult RS, Jessup W, Leake DS. Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. Biochem Pharmacol. 1990;39:1743-50.
7. Frankel EN, Kanner J, German JB, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet. 1993;341:454-7.
8. Vinson JA, Teufel K, Wu N. Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in hamster model. Atherosclerosis. 2001;156:67-72.
9. O'Byrne DJ, Devaraj S, Grundy SM, Jialal I. Comparison of antioxidant effects of Concord grape juice flavonoides and α-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr. 2002;76:1367-74.
10. Demrow H, Slane PR, Folts JD. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation. 1995;91:1182-88.
11. Osman HE, Maalej N, Shanmuganayagam D, Folts JD. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkey. J Nutr. 1998;128:2307-12.
12. Freedman JE, Parker, III C, Li L, Perlman JA, Frei B, Ivanov V, Deak LR, Iafrati MD, Folts JD. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 2001;103:2792-98.
13. Yang TT, Koo MWL. Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion. Life Sci. 2000;66:411-23.
14. Del Bas JM, Fernández-Larrea J, Blay M, Ardevol A, Salvadó MJ, Arola L, Blade C. Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. FASEB J. 2005;19:479-81.
15. Kim HJ, Oh GT, Park YB, Lee MK, Seo HJ, Choi MS. Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. Life Sci. 2004;74:1621-34.
16. Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004;52:2879-86.
17. Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernández ML. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005;135:1911-7.
18. Naissides M, Mamo JCL, James AP, Pal S. The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women. Atherosclerosis. 2006;185:438-45.
19. Kuhn DJ, Burns AC, Kazi A, Dou QP. Direct inhibition of the ubiquitin-proteosome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor. Biochim Biophys Acta. 2004;1682:1-10.
20. Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, Allister E. Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of apoB100 from human HepG2 cells. J Nutr. 2003;133:700-6.
21. Theriault A, Wang Q, Van Iderstine SC, Chen B, Franke AA, Adeli K. Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. J Lipid Res. 2000;41:1969-79.
22. Casaschi A, Wang Q, Dang K, Richards A, Theriault AG. Intestinal apolipoprotein B secretion is inhibited by the flavonoid quercetin: potential role of microsomal triglyceride transfer protein and diacylglycerol acyltransferase. Lipids. 2002;37:647-52.
23. Borradaile NM, de Dreu LE, Barrett PHR, Behrsin CD, Huff MW. Hepatocyte apoB-containing lipoprotein secretion is decreased by grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry. 2003;42:1283-91.
24. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997;89:331-40.
25. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acids synthesis in the liver. J Clin Invest. 2002;109:1125-31.
26. Monagas M, Gómez-Cordovés C, Bartolomé B. Evolution of polyphenols in red wines from Vitis vinifera L. during aging in the bottle. II. Non-anthocyanin phenolic compounds. Eur Food Res Technol. 2005;220:331-40.
27. Monagas M, Gómez-Cordovés C, Bartolomé B. Evolution of polyphenols in red wines from Vitis vinifera L. during aging in the bottle. I. Anthocyanins and pyranoanthocyanins. Eur Food Res Technol. 2005;220:607-14.
28. Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA. Human CD63 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J Lipid Res. 1998;39:777-88.
29. Suárez Y, Fernández C, Gómez-Coronado D, Ferruelo AJ, Dávalos A, Martínez-Botas J, Lasunción MA. Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. Cardiovasc Res. 2004;64:346-55.
30. 24-reductase in mammalian cells. Biochem J. 2002;366:109-19.
31. Contreras JA, Castro M, Bocos C, Herrera E, Lasunción MA. Combination of an enzymatic method and HPLC for the quantitation of cholesterol in cultured cells. J Lipid Res. 1992;33:931-6.
32. Yin L, Zhang Y, Hillgartner FB. Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes. J Biol Chem. 2002;277:19554-65.
33. Suárez Y, González L, Cuadrado A, Berciano M, Lafarga M, Muñoz A. Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Mol Cancer Ther. 2003;2:863-72.
34. Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998;273:20121-27.
35. Brown MS, Goldstein JL. Lowering plasma cholesterol by raising LDL receptor. Atheroscler Suppl. 2004;5:57-9.
36. Bursill C, Roach PD, Bottema CD, Pal S. Green tea upregulates the low-density lipoprotein receptor through the sterol-regulated element binding protein in HepG2 liver cells. J Agric Food Chem. 2001;49:5639-45.
37. Bursill CA, Roach PD. Modulation of cholesterol metabolism by green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells. J Agric Food Chem. 2006;54:1621-6.
38. Liao H, Langmann T, Schmitz G, Zhu Y. Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2002;22:127-32.
39. Hoekstra M, Out R, Kruijt JK, Van Eck M, Van Berkel TJC. Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. J Hepatol. 2005;42:400-7.
40. Tabas I, Weiland DA, Tall AR. Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation. J Biol Chem. 1986;261:3147-55.
41. Havekes LM, De Wit ECM, Princen HMG. Cellular free cholesterol in HepG2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity. Biochem J. 1987;247:739-46.
42. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science. 1986;232:34-47.
43. Sugii S, Reid PC, Ohgami N, Du H, Chang TY. Distinct endosomal compartment in early trafficking of low density lipoprotein-derived cholesterol. J Biol Chem. 2003;278:27180-89.
44. Issandou M, Guillard R, Boullay A-B, Linhart V, López-Pérez E. Upregulation of low-density lipoproteins receptor in human hepatocytes induced by sequestration of free cholesterol in the endosomal/lysosomal compartments. Biochem Pharmacol. 2004;67:2281-89.
45. Zhang J, Dudley-Rucker N, Crowley JR, López-Pérez E, Issandou M, Schaffer JE, Ory DS. The steroidal analog GW707 activates SREBP pathway through disruption of intracellular cholesterol trafficking. J Lipid Res. 2004;45:223-31.
46. Schroeder F, Gallegos AM, Atshaves BP, Storey SM, McIntosh AL, Petrescu AD, Huang H, Starodub O, Chao H, et al. Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol trafficking. Exp Biol Med (Maywood). 2001;226:873-90.
47. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005;81:317S-25.
48. Caimi G, Carollo C, Lo Presti R. Wine and endothelial function. Drugs Exp Clin Res. 2003;29:235-42.