Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis

Environmental Toxicology and Pharmacology

Volumn 37, Issue 2, 2014, Pages 819-827

  Marchi, Patrícia ^a   Paiotti, Ana Paula Ribeiro ^a   Neto, Ricardo Artigiani ^a   Oshima, Celina Tizuko Fujiyama ^a   Ribeiro, Daniel Araki ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Grape juice; Inflammatory bowel disease; TNBS colitis

Indexed keywords

CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; PHENOL DERIVATIVE; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; NOS2 PROTEIN, RAT; PLANT EXTRACT; PTGS2 PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELLULAR DISTRIBUTION; COMET ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DNA DAMAGE; DOWN REGULATION; EPITHELIUM CELL; EXPERIMENTAL COLITIS; GENOTOXICITY; GRAPE JUICE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INFLAMMATORY CELL; MALE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; BEVERAGE; CHEMICALLY INDUCED; COLITIS; COLON; DRUG EFFECTS; FRUIT; IMMUNOLOGY; PATHOLOGY; PHYTOTHERAPY; VITIS; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BEVERAGES; COLITIS; COLON; COMET ASSAY; CYCLOOXYGENASE 2; DNA DAMAGE; FRUIT; MALE; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANT EXTRACTS; RATS, WISTAR; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR-ALPHA; VITIS;

EID: 84896125231     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.02.006     Document Type: Article

References (39)

1. Aguiar O., Gollücke A.P., de Moraes B.B., Pasquini G., Catharino R.R., Riccio M.F., et al. Grape juice concentrate prevents oxidative DNA damage in peripheral blood cells of rats subjected to a high-cholesterol diet. Br. J. Nutr. 2011, 105(5):694-702.
2. Andrade R.G., Ginani J.S., Lopes G.K., Dutra F., Alonso A., Hermes-Lima M. Tannic acid inhibits in vitro iron-dependent free radical formation. Biochimie 2006, 88(9):1287-1296.
3. Appleyard C.B., Wallace J.L. Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs. Am. J. Physiol. 1995, 269(1 Pt 1):G119-G125.
4. Araujo L.F., Soeiro A.M., Fernandes J.L., Serrano C.V. Cardiovascular events: a class effect by COX-2 inhibitors. Arq. Bras. Cardiol. 2005, 85(3):222-229.
5. Aviello G., Canadanovic-Brunet J.M., Milic N., Capasso R., Fattorusso E., Taglialatela-Scafati O., et al. Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa. PLoS ONE 2011, 6(5):e19628.
6. Bisht K., Wagner K.H., Bulmer A.C. Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds. Toxicology 2010, 278(1):88-100.
7. Cross R.K., Wilson K.T. Nitric oxide in inflammatory bowel disease. Inflamm. Bowel Dis. 2003, 9(3):179-189.
8. Cui X., Jin Y., Hofseth A.B., Pena E., Habiger J., Chumanevich A., et al. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prev. Res. (Phila) 2010, 3(4):549-559.
9. Duthie G.G., Duthie S.J., Kyle J.A. Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants. Nutr. Res. Rev. 2000, 13(1):79-106.
10. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998, 115(1):182-205.
11. Geier M.S., Butler R.N., Howarth G.S. Inflammatory bowel disease: current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics. Int. J. Food Microbiol. 2007, 115(1):1-11.
12. Gollücke A.P., Souza J.C., Tavares D.Q. +-Catechin and (-)-epicatechin levels of concentrated and ready-to drink grape juices through storage. Int. J. Food Sci. Technol. 2008, 43(10):1855-1859.
13. Grisham M.B., Pavlick K.P., Laroux F.S., Hoffman J., Bharwani S., Wolf R.E. Nitric oxide and chronic gut inflammation: controversies in inflammatory bowel disease. J. Investig. Med. 2002, 50(4):272-283.
14. Hasler C.M., Bloch A.S., Thomson C.A., Enrione E., Manning C. Position of the American Dietetic Association: functional foods. J. Am. Diet. Assoc. 2004, 5:814-826.
15. Head K.A., Jurenka J.S. Inflammatory bowel disease. Part 1: Ulcerative colitis-pathophysiology and conventional and alternative treatment options. Altern. Med. Rev. 2003, 8(3):247-283.
16. Head K., Jurenka J.S. Inflammatory bowel disease. Part II: Crohn's disease-pathophysiology and conventional and alternative treatment options. Altern. Med. Rev. 2004, 9(4):360-401.
17. Hendrickson B.A., Gokhale R., Cho J.H. Clinical aspects and pathophysiology of inflammatory bowel disease. Clin. Microbiol. Rev. 2002, 15(1):79-94.
18. Hogaboam C.M., Jacobson K., Collins S.M., Blennerhassett M.G. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am. J. Physiol. 1995, 268(4 Pt. 1):G673-G684.
19. Jaworski A.W., Lee C.Y. Fractionation and HPLC determination of grape phenolics. J. Agric. Food Chem. 1987, 35:257-259.
20. Katz J.A., Itoh J., Fiocchi C. Pathogenesis of inflammatory bowel disease. Curr. Opin. Gastroenterol. 1999, 15(4):291-297.
21. Kummer C.L., Coelho T.C. Cycloxygenase-2 inhibitors nonsteroid anti-inflammatory drugs: current issues. Rev. Bras. Anestesiol. 2002, 52(4):498-512.
22. Martín A.R., Villegas I., Sánchez-Hidalgo M., de la Lastra C.A. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br. J. Pharmacol. 2006, 147(8):873-885.
23. Middleton E., Kandaswami C., Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000, 52(4):673-751.
24. Morris G.P., Beck P.L., Herridge M.S., Depew W.T., Szewczuk M.R., Wallace J.L. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989, 96(3):795-803.
25. Olive P.L., Banáth J.P., Durand R.E. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat. Res. 1990, 178(2):AV35-AV42.
26. Paiotti A.P., Artigiani Neto R., Forones N.M., Oshima C.T., Miszputen S.J., Franco M. Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis. Braz. J. Med. Biol. Res. 2007, 40(7):911-918.
27. Papalois A., Gioxari A., Kaliora A.C., Lymperopoulou A., Agrogiannis G., Papada E., Andrikopoulos N.K. Chios mastic fractions in experimental colitis: implication of the nuclear factor κB pathway in cultured HT29 cells. J. Med. Food 2012, 15(11):974-983.
28. Peran L., Camuesco D., Comalada M., et al. Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis. World J. Gastroenterol. 2005, 11:5185-5192.
29. Rosillo M.A., Sanchez-Hidalgo M., Cárdeno A., de la Lastra C.A. Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease. Biochem. Pharmacol. 2011, 82(7):737-745.
30. Salas A., Gironella M., Soriano A., Sans M., Iovanna J., Piqué J.M., et al. Nitric oxide supplementation ameliorates dextran sulfate sodium-induced colitis in mice. Lab. Invest. 2002, 82(5):597-607.
31. Sandborn W.J., Yednock T.A. Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin. Am. J. Gastroenterol. 2003, 98(11):2372-2382.
32. Sasaki M., Elrod J.W., Jordan P., Itoh M., Joh T., Minagar A., et al. CYP450 dietary inhibitors attenuate TNF-alpha-stimulated endothelial molecule expression and leukocyte adhesion. Am. J. Physiol. Cell Physiol. 2004, 286(4):C931-C939.
33. Singh U.P., Singh N.P., Singh B., Hofseth L.J., Price R.L., Nagarkatti M., et al. Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis. J. Pharmacol. Exp. Ther. 2010, 332(3):829-839.
34. Singleton V.L., Esau P. Phenolic substances in grapes and wine, and their significance. Adv. Food Res. Suppl. 1969, 1:1-261.
35. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35(3):206-221.
36. Van Deventer S.J. Tumour necrosis factor and Crohn's disease. Gut 1997, 40(4):443-448.
37. Westbrook A.M., Wei B., Braun J., Schiestl R.H. Intestinal mucosal inflammation leads to systemic genotoxicity in mice. Cancer Res. 2009, 69(11):4827-4834.
38. Xiong B., Sun T.J., Hu W.D., Cheng F.L., Mao M., Zhou Y.F. Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. World J. Gastroenterol. 2005, 11(8):1105-1108.
39. Zhou Y.H., Yu J.P., Liu Y.F., Teng X.J., Ming M., Lv P., et al. Effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Mediators Inflamm. 2006, 5:92642.