Grape powder extract attenuates tumor necrosis factor α-mediated inflammation and insulin resistance in primary cultures of human adipocytes

Journal of Nutritional Biochemistry

Volumn 22, Issue 1, 2011, Pages 89-94

  Chuang, Chia Chi ^a   Bumrungpert, Akkarach ^b   Kennedy, Arion ^a   Overman, Angel ^a   West, Tiffany ^a   Dawson, Brent ^a   McIntosh, Michael K ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Adipocytes; Grape powder extract; Grapes; Inflammation; Insulin resistance

Indexed keywords

CYCLOOXYGENASE 2; GRAPE EXTRACT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLANT EXTRACT; PROTEIN TYROSINE PHOSPHATASE 1B; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GLUCOSE TRANSPORT; GRAPE; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; PROTEIN PHOSPHORYLATION;

ABDOMINAL FAT; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-OBESITY AGENTS; CELLS, CULTURED; FEMALE; FRUIT; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MIDDLE AGED; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VITIS; YOUNG ADULT;

VITACEAE;

EID: 78649916463     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.12.002     Document Type: Article

References (50)

1. Hotamisligil G.S., Arner P., Caro J.F., Atkinson R.L., Spiegelman B.M. Increased adipose expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995, 95:2409-2415.
2. Arkan M.C., Hevener A.L., Greten F.R., Maeda S., Li Z.W., Long J.M., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005, 11:191-198.
3. Gil A., María Aguilera C., Gil-Campos M., Cañete R. Altered signaling and gene expression associated with the immune system and the inflammatory response in obesity. Br J Nutr 2007, 98:S121-S126.
4. Tilg H., Moschen A.R. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 2008, 14:222-231.
5. Wang B., Jenkins J.R., Trayhurn P. Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha. Am J Physiol Endocrinol Metab 2005, 288:E731-E740.
6. Vitseva O.I., Tanriverdi K., Tchkonia T.T., Kirkland J.L., McDonnell M.E., Apovian C.M., et al. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity 2008, 16:932-937.
7. Paik J., Lee J.Y., Hwang D. Signaling pathways for TNFα-induced COX-2 expression: mediation through MAP kinases and NFκB, and inhibition by certain nonsteroidal anti-inflammatory drugs. Adv Exp Med Biol 2002, 507:503-508.
8. Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
9. Uysal K.T., Wiesbrock S.M., Marino M.W., Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-614.
10. Klover P.J., Clementi A.H., Mooney R.A. Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 2005, 146:3417-3427.
11. Weisberg S.P., Hunter D., Huber R., Lemieux J., Slaymaker S., Vaddi K., et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006, 116:115-124.
12. Hsieh P.S., Jin J.S., Chiang C.F., Chan P.C., Chen C.H., Shih K.C. COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity 2009, 17:1150-1157.
13. Tsukumo D.M., Carvalho-Filho M.A., Carvalheira J.B., Prada P.O., Hirabara S.M., Schenka A.A., et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007, 56:1986-1998.
14. Engelman J.A., Berg A.H., Lewis R.Y., Lisanti M.P., Scherer P.E. Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Mol Endocrinol 2000, 14:1557-1569.
15. Hirosumi J., Tuncman G., Chang L., Görgün C.Z., Uysal K.T., Maeda K., et al. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
16. Fujishiro M., Gotoh Y., Katagiri H., Sakoda H., Ogihara T., Anai M., et al. Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol Endocrinol 2003, 17:487-497.
17. Aguirre V., Werner E.D., Giraud J., Lee Y.H., Shoelson S.E., White M.F. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002, 277:1531-1537.
18. Aguirre V., Uchida T., Yenush L., Davis R., White M.F. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 2000, 275:9047-9054.
19. Fernández-Veledo S., Nieto-Vazquez I., Rondinone C.M., Lorenzo M. Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression. Diabetologia 2006, 49:3038-3048.
20. Zabolotny J.M., Kim Y.B., Welsh L.A., Kershaw E.E., Neel B.G., Kahn B.B. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 2008, 283:14230-14241.
21. Goldstein B.J., Bittner-Kowalczyk A., White M.F., Harbeck M. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem 2000, 275:4283-4289.
22. Zern T.L., Wood R.J., Greene C., West K.L., Liu Y., Aggarwal D., et al. Grape polyphenols exert a cardioprotective effect in pre-and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 2005, 135:1911-1917.
23. Cui J., Cordis G.A., Tosaki A., Maulik N., Das D.K. Reduction of myocardial ischemia reperfusion injury with regular consumption of grapes. Ann N Y Acad Sci 2002, 957:302-307.
24. Fuhrman B., Volkova N., Coleman R., Aviram M. Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity. J Nutr 2005, 135:722-728.
25. Seymour E.M., Singer A.A., Bennink M.R., Parikh R.V., Kirakosyan A., Kaufman P.B., et al. Chronic intake of a phytochemical-enriched diet reduces cardiac fibrosis and diastolic dysfunction caused by prolonged salt-sensitive hypertension. J Gerontol A Biol Sci Med Sci 2008, 63:1034-1042.
26. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
27. Stewart L.K., Soileau J.L., Ribnicky D., Wang Z.Q., Raskin I., Poulev A., et al. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism 2008, 57:S39-S46.
28. Rivera L., Morón R., Sánchez M., Zarzuelo A., Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity 2008, 16:2081-2087.
29. Brown J.M., Halvorsen Y.D., Lea-Currie Y.R., Geigerman C., McIntosh M. Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. J Nutr 2001, 131:2316-2321.
30. Brown J.M., Boysen M.S., Jensen S.S., Morrison R.F., Storkson J., Lea-Currie R., et al. Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. J Lipid Res 2003, 44:1287-1300.
31. Pérez-Jiménez J., Saura-Calixto F. Grape products and cardiovascular disease risk factors. Nutr Res Rev 2008, 21:158-173.
32. Sakurai T., Kitadate K., Nishioka H., Fujii H., Kizaki T., Kondoh Y., et al. Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages. J Nutr Biochem 2010, 21:47-54.
33. Lee K.W., Kang N.J., Heo Y.S., Rogozin E.A., Pugliese A., Hwang M.K., et al. Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res 2008, 68:946-955.
34. Nieto-Vazquez I., Fernández-Veledo S., Krämer D.K., Vila-Bedmar R., Garcia-Guerra L., Lorenzo M. Insulin resistance associated to obesity: the link TNF-alpha. Arch Physiol Biochem 2008, 114:183-194.
35. Nieto-Vazquez I., Fernández-Veledo S., de Alvaro C., Rondinone C., Valverde A., Lorenzo M. Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-α-induced insulin resistance. Diabetes 2007, 56:404-413.
36. Ahn J., Lee H., Kim S., Park J., Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun 2008, 373:545-549.
37. Day A.J., Williamson G. Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma. Br J Nutr 2001, 86(Suppl 1):S105-S110.
38. Boyer J., Brown D., Liu R.H. Uptake of quercetin and quercetin 3-glucoside from whole onion and apple peel extracts by Caco-2 cell monolayers. J Agric Food Chem 2004, 52:7172-7179.
39. Castilla P., Echarri R., Dávalos A., Cerrato F., Ortega H., Teruel J.L., et al. Concentrated red grape juice exerts antioxidant, hypolipidemic, and anti-inflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr 2006, 84:252-262.
40. Lakhanpal P., Rai D.K. Quercetin: a versatile flavonoid. Internet J Med Update 2007, 2:20-35.
41. Sun C., Zhang F., Ge X., Yan T., Chen X., Shi X., et al. SIRT1 improves insulin sensitivity under insulin resistance conditions by repressing PTP1B. Cell Metab 2007, 6:307-319.
42. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127:1109-1122.
43. Ahn J., Lee H., Kim S., Ha T. Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2007, 364:972-977.
44. Park C.E., Kim M.J., Lee J.H., Min B.I., Bae H., Choe W., et al. Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med 2007, 39:222-229.
45. Kode A., Rajendrasozhan S., Caito S., Yang S.R., Megson I.L., Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008, 294:L478-L488.
46. Robb E.L., Page M.M., Wiens B.E., Stuart J.A. Molecular mechanisms of oxidative stress resistance induced by resveratrol: specific and progressive induction of MnSOD. Biochem Biophys Res Commun 2008, 367:406-412.
47. Tabata Y., Takano K., Ito T., Iinuma M., Yoshimoto T., Miura H., et al. Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum stress and inflammation. Am J Physiol Cell Physiol 2007, 293:C411-C418.
48. Yu H., Pan C., Zhao S., Wang Z., Zhang H., Wu W. Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother 2008, 62:366-372.
49. Csiszar A., Smith K., Labinskyy N., Orosz Z., Rivera A., Ungvari Z. Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. Am J Physiol Heart Circ Physiol 2006, 291:H1694-H1699.
50. Kroon P.A., Clifford M.N., Crozier A., Day A.J., Donovan J.L., Manach C., et al. How should we assess the effects of exposure to dietary polyphenols in vitro?. Am J Clin Nutr 2004, 80:15-21.