-
1
-
-
0033594961
-
Neurosecretory control of aging in Caenorhabditis elegans
-
Ailion M, Inoue T, Weaver CI, Holdcraft RW, Thomas JH (1999) Neurosecretory control of aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A 96(13): 7394-7397
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.13
, pp. 7394-7397
-
-
Ailion, M.1
Inoue, T.2
Weaver, C.I.3
Holdcraft, R.W.4
Thomas, J.H.5
-
2
-
-
77956645419
-
EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity
-
Alam H, Williams TW, Dumas KJ, Guo C, Yoshina S, Mitani S, Hu PJ (2010) EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab 12(1): 30-41. doi: 10.1016/j.cmet.2010.05.004
-
(2010)
Cell Metab
, vol.12
, Issue.1
, pp. 30-41
-
-
Alam, H.1
Williams, T.W.2
Dumas, K.J.3
Guo, C.4
Yoshina, S.5
Mitani, S.6
Hu, P.J.7
-
3
-
-
0347854376
-
Regulation of C. elegans longevity by specific gustatory and olfactory neurons
-
Alcedo J, Kenyon C (2004) Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41(1): 45-55
-
(2004)
Neuron
, vol.41
, Issue.1
, pp. 45-55
-
-
Alcedo, J.1
Kenyon, C.2
-
4
-
-
0034659485
-
daf-12 encodes a nuclear receptor that regulates the Dauer diapause and developmental age in C. elegans
-
Antebi A, Yeh WH, Tait D, Hedgecock EM, Riddle DL (2000) daf-12 encodes a nuclear receptor that regulates the Dauer diapause and developmental age in C. elegans. Genes Dev 14 (12): 1512-1527
-
(2000)
Genes Dev
, vol.14
, Issue.12
, pp. 1512-1527
-
-
Antebi, A.1
Yeh, W.H.2
Tait, D.3
Hedgecock, E.M.4
Riddle, D.L.5
-
5
-
-
0033576579
-
Regulation of lifespan by sensory perception in Caenorhabditis elegans
-
Apfeld J, Kenyon C (1999) Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402(6763): 804-809. doi: 10.1038/45544
-
(1999)
Nature
, vol.402
, Issue.6763
, pp. 804-809
-
-
Apfeld, J.1
Kenyon, C.2
-
6
-
-
10644282295
-
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
-
Apfeld J, O’Connor G, McDonagh T, DiStefano PS, Curtis R (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev 18(24): 3004-3009
-
(2004)
Genes Dev
, vol.18
, Issue.24
, pp. 3004-3009
-
-
Apfeld, J.1
O’Connor, G.2
McDonagh, T.3
DiStefano, P.S.4
Curtis, R.5
-
7
-
-
43649107519
-
14-3-3 regulates life span by both DAF-16-dependent andindependent mechanisms in Caenorhabditis elegans
-
Araiz C, Chaˆteau MT, Galas S (2008) 14-3-3 regulates life span by both DAF-16-dependent andindependent mechanisms in Caenorhabditis elegans. Exp Gerontol 43(6): 505-519. doi: 10.1016/j.exger.2008.03.001
-
(2008)
Exp Gerontol
, vol.43
, Issue.6
, pp. 505-519
-
-
Araiz, C.1
Chaˆteau, M.T.2
Galas, S.3
-
8
-
-
0037127026
-
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
-
Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C (2002) Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295(5554): 502-505. doi: 10.1126/science.1065768
-
(2002)
Science
, vol.295
, Issue.5554
, pp. 502-505
-
-
Arantes-Oliveira, N.1
Apfeld, J.2
Dillin, A.3
Kenyon, C.4
-
9
-
-
84864065342
-
Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2
-
Baker BM, Nargund AM, Sun T, Haynes CM (2012) Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2. PLoS Genet 8(6), e1002760. doi: 10.1371/journal.pgen.1002760
-
(2012)
PLoS Genet
, vol.8
, Issue.6
, pp. 1002760
-
-
Baker, B.M.1
Nargund, A.M.2
Sun, T.3
Haynes, C.M.4
-
10
-
-
84901731023
-
CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants
-
Baruah A, Chang H, Hall M, Yuan J, Gordon S, Johnson E, Shtessel LL, Yee C, Hekimi S, Derry WB, Lee SS (2014) CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants. PLoS Genet 10(2), e1004097. doi: 10.1371/journal.pgen.1004097
-
(2014)
PLoS Genet
, vol.10
, Issue.2
, pp. 1004097
-
-
Baruah, A.1
Chang, H.2
Hall, M.3
Yuan, J.4
Gordon, S.5
Johnson, E.6
Shtessel, L.L.7
Yee, C.8
Hekimi, S.9
Derry, W.B.10
Lee, S.S.11
-
11
-
-
84905822745
-
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
-
Bennett CF, Vander Wende H, Simko M, Klum S, Barfield S, Choi H, Pineda VV, Kaeberlein M (2014) Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Nat Commun 5: 3483. doi: 10.1038/ncomms4483
-
(2014)
Nat Commun
, vol.5
, pp. 3483
-
-
Bennett, C.F.1
Vander Wende, H.2
Simko, M.3
Klum, S.4
Barfield, S.5
Choi, H.6
Pineda, V.V.7
Kaeberlein, M.8
-
12
-
-
33744976074
-
elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
-
Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L (2006). elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125(6): 1165-1177. doi: 10.1016/j.cell.2006.04.036
-
(2006)
Cell
, vol.125
, Issue.6
, pp. 1165-1177
-
-
Berdichevsky, A.1
Viswanathan, M.2
Horvitz, H.R.3
Guarente, L.4
-
13
-
-
33644772542
-
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling
-
Berman JR, Kenyon C (2006) Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell 124(5): 1055-1068. doi: 10.1016/j.cell.2006.01.039
-
(2006)
Cell
, vol.124
, Issue.5
, pp. 1055-1068
-
-
Berman, J.R.1
Kenyon, C.2
-
14
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop NA, Guarente L (2007) Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447(7144): 545-549. doi: 10.1038/nature05904
-
(2007)
Nature
, vol.447
, Issue.7144
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
15
-
-
29344467120
-
A developmental timing microRNA and its target regulate life span in C. elegans
-
Boehm M, Slack F (2005) A developmental timing microRNA and its target regulate life span in C. elegans. Science 310(5756): 1954-1957. doi: 10.1126/science.1115596
-
(2005)
Science
, vol.310
, Issue.5756
, pp. 1954-1957
-
-
Boehm, M.1
Slack, F.2
-
16
-
-
84859466185
-
The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO
-
Boulias K, Horvitz HR (2012) The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. Cell Metab 15(4): 439-450. doi: 10.1016/j.cmet.2012.02.014
-
(2012)
Cell Metab
, vol.15
, Issue.4
, pp. 439-450
-
-
Boulias, K.1
Horvitz, H.R.2
-
17
-
-
0033529032
-
Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans
-
Braeckman BP, Houthoofd K, De Vreese A, Vanfleteren JR (1999) Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans. Curr Biol 9 (9): 493-496
-
(1999)
Curr Biol
, vol.9
, Issue.9
, pp. 493-496
-
-
Braeckman, B.P.1
Houthoofd, K.2
De Vreese, A.3
Vanfleteren, J.R.4
-
18
-
-
70349999253
-
A role for C. elegans Eph RTK signaling in PTEN regulation
-
Brisbin S, Liu J, Boudreau J, Peng J, Evangelista M, Chin-Sang I (2009) A role for C. elegans Eph RTK signaling in PTEN regulation. Dev Cell 17(4): 459-469. doi: 10.1016/j.devcel.2009.08.009
-
(2009)
Dev Cell
, vol.17
, Issue.4
, pp. 459-469
-
-
Brisbin, S.1
Liu, J.2
Boudreau, J.3
Peng, J.4
Evangelista, M.5
Chin-Sang, I.6
-
19
-
-
33746653423
-
Genetic regulation of unsaturated fatty acid composition in C. elegans
-
Brock TJ, Browse J, Watts JL (2006) Genetic regulation of unsaturated fatty acid composition in C. elegans. PLoS Genet 2(7), e108. doi: 10.1371/journal.pgen.0020108
-
(2006)
PLoS Genet
, vol.2
, Issue.7
, pp. 108
-
-
Brock, T.J.1
Browse, J.2
Watts, J.L.3
-
20
-
-
47549100826
-
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans
-
Budovskaya YV, Wu K, Southworth LK, Jiang M, Tedesco P, Johnson TE, Kim SK (2008) An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 134(2): 291-303. doi: 10.1016/j.cell.2008.05.044
-
(2008)
Cell
, vol.134
, Issue.2
, pp. 291-303
-
-
Budovskaya, Y.V.1
Wu, K.2
Southworth, L.K.3
Jiang, M.4
Tedesco, P.5
Johnson, T.E.6
Kim, S.K.7
-
21
-
-
80053168829
-
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
-
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477 (7365): 482-485. doi: 10.1038/nature10296
-
(2011)
Nature
, vol.477
, Issue.7365
, pp. 482-485
-
-
Burnett, C.1
Valentini, S.2
Cabreiro, F.3
Goss, M.4
Somogyvari, M.5
Piper, M.D.6
Hoddinott, M.7
Sutphin, G.L.8
Leko, V.9
McElwee, J.J.10
Vazquez-Manrique, R.P.11
Orfila, A.M.12
Ackerman, D.13
Au, C.14
Vinti, G.15
Riesen, M.16
Howard, K.17
Neri, C.18
Bedalov, A.19
Kaeberlein, M.20
Soti, C.21
Partridge, L.22
Gems, D.23
more..
-
22
-
-
84860390185
-
Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage
-
Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP, Gems D (2011) Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med 51(8): 1575-1582. doi: 10.1016/j.freeradbiomed.2011.07.020
-
(2011)
Free Radic Biol Med
, vol.51
, Issue.8
, pp. 1575-1582
-
-
Cabreiro, F.1
Ackerman, D.2
Doonan, R.3
Araiz, C.4
Back, P.5
Papp, D.6
Braeckman, B.P.7
Gems, D.8
-
23
-
-
0141447476
-
Age of ovary determines remaining life expectancy in old ovariectomized mice
-
Cargill SL, Carey JR, Muller HG, Anderson G (2003) Age of ovary determines remaining life expectancy in old ovariectomized mice. Aging Cell 2(3): 185-190
-
(2003)
Aging Cell
, vol.2
, Issue.3
, pp. 185-190
-
-
Cargill, S.L.1
Carey, J.R.2
Muller, H.G.3
Anderson, G.4
-
24
-
-
67651004289
-
A conserved ubiquitination pathway determines longevity in response to diet restriction
-
Carrano AC, Liu Z, Dillin A, Hunter T (2009) A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460(7253): 396-399. doi: 10.1038/nature08130
-
(2009)
Nature
, vol.460
, Issue.7253
, pp. 396-399
-
-
Carrano, A.C.1
Liu, Z.2
Dillin, A.3
Hunter, T.4
-
25
-
-
84900017249
-
A Kruppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans
-
Carrano AC, Dillin A, Hunter T (2014) A Kruppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. Nat Commun 5: 3772. doi: 10.1038/ncomms4772
-
(2014)
Nat Commun
, vol.5
, pp. 3772
-
-
Carrano, A.C.1
Dillin, A.2
Hunter, T.3
-
26
-
-
84905041609
-
A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans
-
Chamoli M, Singh A, Malik Y, Mukhopadhyay A (2014) A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans. Aging Cell 13(4): 641-655. doi: 10.1111/acel.12218
-
(2014)
Aging Cell
, vol.13
, Issue.4
, pp. 641-655
-
-
Chamoli, M.1
Singh, A.2
Malik, Y.3
Mukhopadhyay, A.4
-
27
-
-
67149107430
-
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
-
Chen D, Thomas EL, Kapahi P (2009) HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet 5(5), e1000486. doi: 10.1371/journal.pgen.1000486
-
(2009)
PLoS Genet
, vol.5
, Issue.5
, pp. 1000486
-
-
Chen, D.1
Thomas, E.L.2
Kapahi, P.3
-
28
-
-
84883787635
-
Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation
-
Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ (2013a) Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell 12(5): 932-940. doi: 10.1111/acel.12120
-
(2013)
Aging Cell
, vol.12
, Issue.5
, pp. 932-940
-
-
Chen, A.T.1
Guo, C.2
Dumas, K.J.3
Ashrafi, K.4
Hu, P.J.5
-
29
-
-
84890973318
-
Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans
-
Chen D, Li PW, Goldstein BA, Cai W, Thomas EL, Chen F, Hubbard AE, Melov S, Kapahi P (2013b) Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep 5(6): 1600-1610. doi: 10.1016/j.celrep.2013.11.018
-
(2013)
Cell Rep
, vol.5
, Issue.6
, pp. 1600-1610
-
-
Chen, D.1
Li, P.W.2
Goldstein, B.A.3
Cai, W.4
Thomas, E.L.5
Chen, F.6
Hubbard, A.E.7
Melov, S.8
Kapahi, P.9
-
30
-
-
84862930510
-
HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity
-
Chiang WC, Ching TT, Lee HC, Mousigian C, Hsu AL (2012) HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. Cell 148(1-2): 322-334. doi: 10.1016/j.cell.2011.12.019
-
(2012)
Cell
, vol.148
, Issue.1-2
, pp. 322-334
-
-
Chiang, W.C.1
Ching, T.T.2
Lee, H.C.3
Mousigian, C.4
Hsu, A.L.5
-
31
-
-
77957226879
-
drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans
-
Ching TT, Paal AB, Mehta A, Zhong L, Hsu AL (2010) drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans. Aging Cell 9 (4): 545-557. doi: 10.1111/j.1474-9726.2010.00580.x
-
(2010)
Aging Cell
, vol.9
, Issue.4
, pp. 545-557
-
-
Ching, T.T.1
Paal, A.B.2
Mehta, A.3
Zhong, L.4
Hsu, A.L.5
-
32
-
-
66149087761
-
A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
-
Cristina D, Cary M, Lunceford A, Clarke C, Kenyon C (2009) A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet 5(4), e1000450. doi: 10.1371/journal.pgen.1000450
-
(2009)
PLoS Genet
, vol.5
, Issue.4
, pp. 1000450
-
-
Cristina, D.1
Cary, M.2
Lunceford, A.3
Clarke, C.4
Kenyon, C.5
-
33
-
-
34247569105
-
Lifespan regulation by evolutionarily conserved genes essential for viability
-
Curran SP, Ruvkun G (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3(4), e56. doi: 10.1371/journal.pgen.0030056
-
(2007)
PLoS Genet
, vol.3
, Issue.4
, pp. 56
-
-
Curran, S.P.1
Ruvkun, G.2
-
34
-
-
67649491263
-
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
-
Curran SP, Wu X, Riedel CG, Ruvkun G (2009) A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459(7250): 1079-1084. doi: 10.1038/nature08106
-
(2009)
Nature
, vol.459
, Issue.7250
, pp. 1079-1084
-
-
Curran, S.P.1
Wu, X.2
Riedel, C.G.3
Ruvkun, G.4
-
35
-
-
33646926969
-
Aging networks in Caenorhabditis elegans: AMPactivated protein kinase (aak-2) links multiple aging and metabolism pathways
-
Curtis R, O’Connor G, Di Stefano PS (2006) Aging networks in Caenorhabditis elegans: AMPactivated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell 5 (2): 119-126. doi: 10.1111/j.1474-9726.2006.00205.x
-
(2006)
Aging Cell
, vol.5
, Issue.2
, pp. 119-126
-
-
Curtis, R.1
O’Connor, G.2
Di Stefano, P.S.3
-
36
-
-
8544242688
-
Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans
-
de Jong L, Meng Y, Dent J, Hekimi S (2004) Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics 168(2): 845-854. doi: 10.1534/genetics.104.028605
-
(2004)
Genetics
, vol.168
, Issue.2
, pp. 845-854
-
-
De Jong, L.1
Meng, Y.2
Dent, J.3
Hekimi, S.4
-
37
-
-
78650490230
-
MicroRNAs both promote and antagonize longevity in C. elegans
-
de Lencastre A, Pincus Z, Zhou K, Kato M, Lee SS, Slack FJ (2010) MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol 20(24): 2159-2168. doi: 10.1016/j.cub.2010.11.015
-
(2010)
Curr Biol
, vol.20
, Issue.24
, pp. 2159-2168
-
-
De Lencastre, A.1
Pincus, Z.2
Zhou, K.3
Kato, M.4
Lee, S.S.5
Slack, F.J.6
-
38
-
-
0037174629
-
Timing requirements for insulin/IGF-1 signaling in C. elegans
-
Dillin A, Crawford DK, Kenyon C (2002a) Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298(5594): 830-834. doi: 10.1126/science.1074240
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 830-834
-
-
Dillin, A.1
Crawford, D.K.2
Kenyon, C.3
-
39
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002b) Rates of behavior and aging specified by mitochondrial function during development. Science 298(5602): 2398-2401. doi: 10.1126/science.1077780
-
(2002)
Science
, vol.298
, Issue.5602
, pp. 2398-2401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
Lehrer-Graiwer, J.4
Hsin, H.5
Fraser, A.G.6
Kamath, R.S.7
Ahringer, J.8
Kenyon, C.9
-
40
-
-
0028807085
-
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
-
Dorman JB, Albinder B, Shroyer T, Kenyon C (1995) The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141(4): 1399-1406
-
(1995)
Genetics
, vol.141
, Issue.4
, pp. 1399-1406
-
-
Dorman, J.B.1
Albinder, B.2
Shroyer, T.3
Kenyon, C.4
-
41
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chainmediated longevity
-
Durieux J, Wolff S, Dillin A (2011) The cell-non-autonomous nature of electron transport chainmediated longevity. Cell 144(1): 79-91. doi: 10.1016/j.cell.2010.12.016
-
(2011)
Cell
, vol.144
, Issue.1
, pp. 79-91
-
-
Durieux, J.1
Wolff, S.2
Dillin, A.3
-
42
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ (2011) Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331(6016): 456-461. doi: 10.1126/science.1196371
-
(2011)
Science
, vol.331
, Issue.6016
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
Asara, J.M.11
Fitzpatrick, J.12
Dillin, A.13
Viollet, B.14
Kundu, M.15
Hansen, M.16
Shaw, R.J.17
-
43
-
-
18844382368
-
Functional interaction between beta-catenin and FOXO in oxidative stress signaling
-
Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308(5725): 1181-1184. doi: 10.1126/science.1109083
-
(2005)
Science
, vol.308
, Issue.5725
, pp. 1181-1184
-
-
Essers, M.A.1
De Vries-Smits, L.M.2
Barker, N.3
Polderman, P.E.4
Burgering, B.M.5
Korswagen, H.C.6
-
44
-
-
84921357250
-
A long noncoding RNA on the ribosome is required for lifespan extension
-
Essers Paul B, Nonnekens J, Goos Yvonne J, Betist Marco C, Viester Marjon D, Mossink B, Lansu N, Korswagen Hendrik C, Jelier R, Brenkman Arjan B, MacInnes Alyson W (2015) A long noncoding RNA on the ribosome is required for lifespan extension. Cell Rep 10(3): 339-345. doi: 10.1016/j.celrep.2014.12.029
-
(2015)
Cell Rep
, vol.10
, Issue.3
, pp. 339-345
-
-
Essers Paul, B.1
Nonnekens, J.2
Goos Yvonne, J.3
Betist Marco, C.4
Betist Marco, C.5
Mossink, B.6
Lansu, N.7
Korswagen Hendrik, C.8
Jelier, R.9
Brenkman Arjan, B.10
MacInnes Alyson, W.11
-
45
-
-
79952455618
-
TOR signaling never gets old: Aging, longevity and TORC1 activity
-
Evans DS, Kapahi P, Hsueh WC, Kockel L (2011) TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev 10(2): 225-237. doi: 10.1016/j.arr.2010.04.001
-
(2011)
Ageing Res Rev
, vol.10
, Issue.2
, pp. 225-237
-
-
Evans, D.S.1
Kapahi, P.2
Hsueh, W.C.3
Kockel, L.4
-
46
-
-
84925488579
-
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
-
Ewald CY, Landis JN, Abate JP, Murphy CT, Blackwell TK (2014) Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. doi: 10.1038/nature14021
-
(2014)
Nature
-
-
Ewald, C.Y.1
Landis, J.N.2
Abate, J.P.3
Murphy, C.T.4
Blackwell, T.K.5
-
47
-
-
0031030678
-
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
-
Ewbank JJ, Barnes TM, Lakowski B, Lussier M, Bussey H, Hekimi S (1997) Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science 275 (5302): 980-983
-
(1997)
Science
, vol.275
, Issue.5302
, pp. 980-983
-
-
Ewbank, J.J.1
Barnes, T.M.2
Lakowski, B.3
Lussier, M.4
Bussey, H.5
Hekimi, S.6
-
48
-
-
0035515923
-
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
-
Feng J, Bussiere F, Hekimi S (2001) Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 1(5): 633-644
-
(2001)
Dev Cell
, vol.1
, Issue.5
, pp. 633-644
-
-
Feng, J.1
Bussiere, F.2
Hekimi, S.3
-
49
-
-
84897413383
-
An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology
-
Fernandes de Abreu DA, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, Lopez-Moyado IF, Vaggi F, Cornils A, Regenass M, Neagu A, Ostojic I, Liu C, Cho Y, Sifoglu D, Shen Y, Fontana W, Lu H, Csikasz-Nagy A, Murphy CT, Antebi A, Blanc E, Apfeld J, Zhang Y, Alcedo J, Chʼng Q (2014) An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet 10(3), e1004225. doi: 10.1371/journal.pgen.1004225
-
(2014)
PLoS Genet
, vol.10
, Issue.3
, pp. 1004225
-
-
Fernandes De Abreu, D.A.1
Caballero, A.2
Fardel, P.3
Stroustrup, N.4
Chen, Z.5
Lee, K.6
Keyes, W.D.7
Nash, Z.M.8
Lopez-Moyado, I.F.9
Vaggi, F.10
Cornils, A.11
Regenass, M.12
Neagu, A.13
Ostojic, I.14
Liu, C.15
Cho, Y.16
Sifoglu, D.17
Shen, Y.18
Fontana, W.19
Lu, H.20
Csikasz-Nagy, A.21
Murphy, C.T.22
Antebi, A.23
Blanc, E.24
Apfeld, J.25
Zhang, Y.26
Alcedo, J.27
Chʼng, Q.28
more..
-
50
-
-
33646908532
-
The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms
-
Fisher AL, Lithgow GJ (2006) The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. Aging Cell 5(2): 127-138. doi: 10.1111/j.1474-9726.2006.00203.x
-
(2006)
Aging Cell
, vol.5
, Issue.2
, pp. 127-138
-
-
Fisher, A.L.1
Lithgow, G.J.2
-
51
-
-
44049098020
-
Drosophila germ-line modulation of insulin signaling and lifespan
-
Flatt T, Min KJ, D’Alterio C, Villa-Cuesta E, Cumbers J, Lehmann R, Jones DL, Tatar M (2008) Drosophila germ-line modulation of insulin signaling and lifespan. Proc Natl Acad Sci U S A 105(17): 6368-6373. doi: 10.1073/pnas.0709128105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.17
, pp. 6368-6373
-
-
Flatt, T.1
Min, K.J.2
D’Alterio, C.3
Villa-Cuesta, E.4
Cumbers, J.5
Lehmann, R.6
Jones, D.L.7
Tatar, M.8
-
52
-
-
0023678537
-
Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
-
Friedman DB, Johnson TE (1988) Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol 43(4): B102-B109
-
(1988)
J Gerontol
, vol.43
, Issue.4
, pp. B102-B109
-
-
Friedman, D.B.1
Johnson, T.E.2
-
53
-
-
84872023523
-
Genes that act downstream of sensory neurons to influence longevity, Dauer formation, and pathogen responses in Caenorhabditis elegans
-
Gaglia MM, Jeong DE, Ryu EA, Lee D, Kenyon C, Lee SJ (2012) Genes that act downstream of sensory neurons to influence longevity, Dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet 8(12), e1003133. doi: 10.1371/journal.pgen.1003133
-
(2012)
PLoS Genet
, vol.8
, Issue.12
, pp. 1003133
-
-
Gaglia, M.M.1
Jeong, D.E.2
Ryu, E.A.3
Lee, D.4
Kenyon, C.5
Lee, S.J.6
-
54
-
-
0036021375
-
Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation
-
Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002) Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161(3): 1101-1112
-
(2002)
Genetics
, vol.161
, Issue.3
, pp. 1101-1112
-
-
Garigan, D.1
Hsu, A.L.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Kenyon, C.6
-
55
-
-
0038047438
-
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens
-
Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM (2003) Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 300 (5627): 1921. doi: 10.1126/science.1080147
-
(2003)
Science
, vol.300
, Issue.5627
, pp. 1921
-
-
Garsin, D.A.1
Villanueva, J.M.2
Begun, J.3
Kim, D.H.4
Sifri, C.D.5
Calderwood, S.B.6
Ruvkun, G.7
Ausubel, F.M.8
-
56
-
-
0031685525
-
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans
-
Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, Larsen PL, Riddle DL (1998) Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150(1): 129-155
-
(1998)
Genetics
, vol.150
, Issue.1
, pp. 129-155
-
-
Gems, D.1
Sutton, A.J.2
Sundermeyer, M.L.3
Albert, P.S.4
King, K.V.5
Edgley, M.L.6
Larsen, P.L.7
Riddle, D.L.8
-
57
-
-
0035656274
-
A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
-
Gerisch B, Weitzel C, Kober-Eisermann C, Rottiers V, Antebi A (2001) A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev Cell 1(6): 841-851
-
(2001)
Dev Cell
, vol.1
, Issue.6
, pp. 841-851
-
-
Gerisch, B.1
Weitzel, C.2
Kober-Eisermann, C.3
Rottiers, V.4
Antebi, A.5
-
58
-
-
34247563364
-
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
-
Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A (2007) A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A 104(12): 5014-5019. doi: 10.1073/pnas.0700847104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.12
, pp. 5014-5019
-
-
Gerisch, B.1
Rottiers, V.2
Li, D.3
Motola, D.L.4
Cummins, C.L.5
Lehrach, H.6
Mangelsdorf, D.J.7
Antebi, A.8
-
59
-
-
84880506958
-
Loss of the Birt-Hogg-Dube gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner
-
Gharbi H, Fabretti F, Bharill P, Rinschen MM, Brinkkotter S, Frommolt P, Burst V, Schermer B, Benzing T, Muller RU (2013) Loss of the Birt-Hogg-Dube gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner. Aging Cell 12(4): 593-603. doi: 10.1111/acel.12081
-
(2013)
Aging Cell
, vol.12
, Issue.4
, pp. 593-603
-
-
Gharbi, H.1
Fabretti, F.2
Bharill, P.3
Rinschen, M.M.4
Brinkkotter, S.5
Frommolt, P.6
Burst, V.7
Schermer, B.8
Benzing, T.9
Muller, R.U.10
-
60
-
-
34250882745
-
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
-
Ghazi A, Henis-Korenblit S, Kenyon C (2007) Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A 104(14): 5947-5952. doi: 10.1073/pnas.0700638104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.14
, pp. 5947-5952
-
-
Ghazi, A.1
Henis-Korenblit, S.2
Kenyon, C.3
-
61
-
-
70349668985
-
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans
-
Ghazi A, Henis-Korenblit S, Kenyon C (2009) A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet 5 (9), e1000639. doi: 10.1371/journal.pgen.1000639
-
(2009)
PLoS Genet
, vol.5
, Issue.9
, pp. 1000639
-
-
Ghazi, A.1
Henis-Korenblit, S.2
Kenyon, C.3
-
62
-
-
79953683136
-
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans
-
Goudeau J, Bellemin S, Toselli-Mollereau E, Shamalnasab M, Chen Y, Aguilaniu H (2011) Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. PLoS Biol 9(3), e1000599. doi: 10.1371/journal.pbio.1000599
-
(2011)
PLoS Biol
, vol.9
, Issue.3
, pp. 1000599
-
-
Goudeau, J.1
Bellemin, S.2
Toselli-Mollereau, E.3
Shamalnasab, M.4
Chen, Y.5
Aguilaniu, H.6
-
63
-
-
84907212907
-
Metabolic control of cell death
-
Green DR, Galluzzi L, Kroemer G (2014) Metabolic control of cell death. Science 345 (6203): 1250256
-
(2014)
Science
, vol.345
, Issue.6203
, pp. 1250256
-
-
Green, D.R.1
Galluzzi, L.2
Kroemer, G.3
-
64
-
-
63549108476
-
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
-
Greer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8(2): 113-127. doi: 10.1111/j.1474-9726.2009.00459.x
-
(2009)
Aging Cell
, vol.8
, Issue.2
, pp. 113-127
-
-
Greer, E.L.1
Brunet, A.2
-
65
-
-
34848850156
-
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
-
Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, Brunet A (2007) An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 17(19): 1646-1656. doi: 10.1016/j.cub.2007.08.047
-
(2007)
Curr Biol
, vol.17
, Issue.19
, pp. 1646-1656
-
-
Greer, E.L.1
Dowlatshahi, D.2
Banko, M.R.3
Villen, J.4
Hoang, K.5
Blanchard, D.6
Gygi, S.P.7
Brunet, A.8
-
66
-
-
67651172980
-
Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans
-
Hahm JH, Kim S, Paik YK (2009) Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans. Aging Cell 8(4): 473-483. doi: 10.1111/j.1474-9726.2009.00495.x
-
(2009)
Aging Cell
, vol.8
, Issue.4
, pp. 473-483
-
-
Hahm, J.H.1
Kim, S.2
Paik, Y.K.3
-
67
-
-
22344443522
-
A systematic RNAi screen for longevity genes in C. elegans
-
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS (2005) A systematic RNAi screen for longevity genes in C. elegans. Genes Dev 19(13): 1544-1555. doi: 10.1101/gad.1308205
-
(2005)
Genes Dev
, vol.19
, Issue.13
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
Liu, W.4
Odell, I.5
Ruvkun, G.6
Lee, S.S.7
-
68
-
-
33645472504
-
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
-
Hansen M, Hsu AL, Dillin A, Kenyon C (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1(1): 119-128. doi: 10.1371/journal.pgen.0010017
-
(2005)
PLoS Genet
, vol.1
, Issue.1
, pp. 119-128
-
-
Hansen, M.1
Hsu, A.L.2
Dillin, A.3
Kenyon, C.4
-
69
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6(1): 95-110. doi: 10.1111/j.1474-9726.2006.00267.x
-
(2007)
Aging Cell
, vol.6
, Issue.1
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
Kenyon, C.6
-
70
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4(2), e24. doi: 10.1371/journal.pgen.0040024
-
(2008)
PLoS Genet
, vol.4
, Issue.2
, pp. 24
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
Onken, B.4
Driscoll, M.5
Kenyon, C.6
-
71
-
-
84919621076
-
AMPK-sensing energy while talking to other signaling pathways
-
Hardie DG (2014) AMPK-sensing energy while talking to other signaling pathways. Cell Metab 20(6): 939-952. doi: 10.1016/j.cmet.2014.09.013
-
(2014)
Cell Metab
, vol.20
, Issue.6
, pp. 939-952
-
-
Hardie, D.G.1
-
72
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11 (3): 298-300
-
(1956)
J Gerontol
, vol.11
, Issue.3
, pp. 298-300
-
-
Harman, D.1
-
73
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman D (1972) The biologic clock: the mitochondria? J Am Geriatr Soc 20(4): 145-147
-
(1972)
J Am Geriatr Soc
, vol.20
, Issue.4
, pp. 145-147
-
-
Harman, D.1
-
74
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460(7253): 392-395. doi: 10.1038/nature08221
-
(2009)
Nature
, vol.460
, Issue.7253
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
Pahor, M.11
Javors, M.A.12
Fernandez, E.13
Miller, R.A.14
-
75
-
-
33947401070
-
Autophagy regulates ageing in C. elegans
-
Hars ES, Qi H, Ryazanov AG, Jin S, Cai L, Hu C, Liu LF (2007) Autophagy regulates ageing in C. elegans. Autophagy 3(2): 93-95
-
(2007)
Autophagy
, vol.3
, Issue.2
, pp. 93-95
-
-
Hars, E.S.1
Qi, H.2
Ryazanov, A.G.3
Jin, S.4
Cai, L.5
Hu, C.6
Liu, L.F.7
-
76
-
-
66749103175
-
Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans
-
Hashimoto Y, Ookuma S, Nishida E (2009) Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. Genes Cells 14(6): 717-726. doi: 10.1111/j.1365-2443.2009.01306.x
-
(2009)
Genes Cells
, vol.14
, Issue.6
, pp. 717-726
-
-
Hashimoto, Y.1
Ookuma, S.2
Nishida, E.3
-
77
-
-
84879602902
-
Evaluating and responding to mitochondrial dysfunction: The mitochondrial unfolded-protein response and beyond
-
Haynes CM, Fiorese CJ, Lin YF (2013) Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends Cell Biol 23(7): 311-318. doi: 10.1016/j.tcb.2013.02.002
-
(2013)
Trends Cell Biol
, vol.23
, Issue.7
, pp. 311-318
-
-
Haynes, C.M.1
Fiorese, C.J.2
Lin, Y.F.3
-
78
-
-
84880798936
-
Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans
-
Heestand BN, Shen Y, Liu W, Magner DB, Storm N, Meharg C, Habermann B, Antebi A (2013) Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet 9(7), e1003651. doi: 10.1371/journal.pgen.1003651
-
(2013)
PLoS Genet
, vol.9
, Issue.7
, pp. 1003651
-
-
Heestand, B.N.1
Shen, Y.2
Liu, W.3
Magner, D.B.4
Storm, N.5
Meharg, C.6
Habermann, B.7
Antebi, A.8
-
79
-
-
0035846604
-
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
Henderson ST, Johnson TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11(24): 1975-1980
-
(2001)
Curr Biol
, vol.11
, Issue.24
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
80
-
-
77953091249
-
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
-
Henis-Korenblit S, Zhang P, Hansen M, McCormick M, Lee SJ, Cary M, Kenyon C (2010) Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A 107(21): 9730-9735. doi: 10.1073/pnas.1002575107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.21
, pp. 9730-9735
-
-
Henis-Korenblit, S.1
Zhang, P.2
Hansen, M.3
McCormick, M.4
Lee, S.J.5
Cary, M.6
Kenyon, C.7
-
81
-
-
11144355021
-
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
-
Hertweck M, Gobel C, Baumeister R (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6(4): 577-588
-
(2004)
Dev Cell
, vol.6
, Issue.4
, pp. 577-588
-
-
Hertweck, M.1
Gobel, C.2
Baumeister, R.3
-
82
-
-
0032782364
-
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
-
Honda Y, Honda S (1999) The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J 13(11): 1385-1393
-
(1999)
FASEB J
, vol.13
, Issue.11
, pp. 1385-1393
-
-
Honda, Y.1
Honda, S.2
-
83
-
-
59649120539
-
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
-
Honjoh S, Yamamoto T, Uno M, Nishida E (2009) Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature 457(7230): 726-730. doi: 10.1038/nature07583
-
(2009)
Nature
, vol.457
, Issue.7230
, pp. 726-730
-
-
Honjoh, S.1
Yamamoto, T.2
Uno, M.3
Nishida, E.4
-
84
-
-
84857124521
-
C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling
-
Honnen SJ, Buchter C, Schroder V, Hoffmann M, Kohara Y, Kampkotter A, Bossinger O (2012) C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling. PLoS One 7(2), e32183. doi: 10.1371/journal.pone.0032183
-
(2012)
PLoS One
, vol.7
, Issue.2
, pp. 32183
-
-
Honnen, S.J.1
Buchter, C.2
Schroder, V.3
Hoffmann, M.4
Kohara, Y.5
Kampkotter, A.6
Bossinger, O.7
-
85
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497 (7450): 451-457. doi: 10.1038/nature12188
-
(2013)
Nature
, vol.497
, Issue.7450
, pp. 451-457
-
-
Houtkooper, R.H.1
Mouchiroud, L.2
Ryu, D.3
Moullan, N.4
Katsyuba, E.5
Knott, G.6
Williams, R.W.7
Auwerx, J.8
-
86
-
-
0033609291
-
Signals from the reproductive system regulate the lifespan of C. elegans
-
Hsin H, Kenyon C (1999) Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399(6734): 362-366. doi: 10.1038/20694
-
(1999)
Nature
, vol.399
, Issue.6734
, pp. 362-366
-
-
Hsin, H.1
Kenyon, C.2
-
87
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu AL, Murphy CT, Kenyon C (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300(5622): 1142-1145. doi: 10.1126/science.1083701
-
(2003)
Science
, vol.300
, Issue.5622
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
88
-
-
79955563685
-
The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans
-
Huang X, Zhang H, Zhang H (2011) The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. Development 138(10): 2059-2068. doi: 10.1242/dev.057109
-
(2011)
Development
, vol.138
, Issue.10
, pp. 2059-2068
-
-
Huang, X.1
Zhang, H.2
Zhang, H.3
-
89
-
-
84867756222
-
Mitochondria and organismal longevity
-
Hwang AB, Jeong DE, Lee SJ (2012) Mitochondria and organismal longevity. Curr Genomics 13 (7): 519-532. doi: 10.2174/138920212803251427
-
(2012)
Curr Genomics
, vol.13
, Issue.7
, pp. 519-532
-
-
Hwang, A.B.1
Jeong, D.E.2
Lee, S.J.3
-
90
-
-
84908068704
-
Feedback regulation via AMPK and HIF-1 mediates ROSdependent longevity in Caenorhabditis elegans
-
Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ (2014) Feedback regulation via AMPK and HIF-1 mediates ROSdependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A 111(42): E4458-E4467. doi: 10.1073/pnas.1411199111
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.42
, pp. E4458-E4467
-
-
Hwang, A.B.1
Ryu, E.A.2
Artan, M.3
Chang, H.W.4
Kabir, M.H.5
Nam, H.J.6
Lee, D.7
Yang, J.S.8
Kim, S.9
Mair, W.B.10
Lee, C.11
Lee, S.S.12
Lee, S.J.13
-
91
-
-
84872017766
-
Regulation of lifespan by chemosensory and thermosensory systems: Findings in invertebrates and their implications in mammalian aging
-
Jeong DE, Artan M, Seo K, Lee SJ (2012) Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet 3: 218. doi: 10.3389/fgene.2012.00218
-
(2012)
Front Genet
, vol.3
, pp. 218
-
-
Jeong, D.E.1
Artan, M.2
Seo, K.3
Lee, S.J.4
-
92
-
-
0036333147
-
DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity
-
Jia K, Albert PS, Riddle DL (2002) DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development 129(1): 221-231
-
(2002)
Development
, vol.129
, Issue.1
, pp. 221-231
-
-
Jia, K.1
Albert, P.S.2
Riddle, D.L.3
-
93
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131 (16): 3897-3906. doi: 10.1242/dev.01255
-
(2004)
Development
, vol.131
, Issue.16
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
94
-
-
35848937781
-
Autophagy is required for dietary restriction-mediated life span extension in C. elegans
-
Jia K, Levine B (2007) Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3(6): 597-599
-
(2007)
Autophagy
, vol.3
, Issue.6
, pp. 597-599
-
-
Jia, K.1
Levine, B.2
-
95
-
-
70149085849
-
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance
-
Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, Gilpin C, Levine B (2009) Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci U S A 106(34): 14564-14569. doi: 10.1073/pnas.0813319106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.34
, pp. 14564-14569
-
-
Jia, K.1
Thomas, C.2
Akbar, M.3
Sun, Q.4
Adams-Huet, B.5
Gilpin, C.6
Levine, B.7
-
96
-
-
79960936857
-
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway
-
Jin C, Li J, Green CD, Yu X, Tang X, Han D, Xian B, Wang D, Huang X, Cao X, Yan Z, Hou L, Liu J, Shukeir N, Khaitovich P, Chen CD, Zhang H, Jenuwein T, Han JD (2011) Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab 14(2): 161-172. doi: 10.1016/j.cmet.2011.07.001
-
(2011)
Cell Metab
, vol.14
, Issue.2
, pp. 161-172
-
-
Jin, C.1
Li, J.2
Green, C.D.3
Yu, X.4
Tang, X.5
Han, D.6
Xian, B.7
Wang, D.8
Huang, X.9
Cao, X.10
Yan, Z.11
Hou, L.12
Liu, J.13
Shukeir, N.14
Khaitovich, P.15
Chen, C.D.16
Zhang, H.17
Jenuwein, T.18
Han, J.D.19
-
97
-
-
84872527628
-
mTOR is a key modulator of ageing and agerelated disease
-
Johnson SC, Rabinovitch PS, Kaeberlein M (2013) mTOR is a key modulator of ageing and agerelated disease. Nature 493(7432): 338-345. doi: 10.1038/nature11861
-
(2013)
Nature
, vol.493
, Issue.7432
, pp. 338-345
-
-
Johnson, S.C.1
Rabinovitch, P.S.2
Kaeberlein, M.3
-
98
-
-
84901303171
-
The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals
-
Johnson DW, Llop JR, Farrell SF, Yuan J, Stolzenburg LR, Samuelson AV (2014) The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals. PLoS Genet 10(4), e1004278. doi: 10.1371/journal.pgen.1004278
-
(2014)
PLoS Genet
, vol.10
, Issue.4
, pp. 1004278
-
-
Johnson, D.W.1
Llop, J.R.2
Farrell, S.F.3
Yuan, J.4
Stolzenburg, L.R.5
Samuelson, A.V.6
-
99
-
-
77954855717
-
The role of insulin/IGF-like signaling in C. elegans longevity and aging
-
Kaletsky R, Murphy CT (2010) The role of insulin/IGF-like signaling in C. elegans longevity and aging. Dis Model Mech 3(7-8): 415-419. doi: 10.1242/dmm.001040
-
(2010)
Dis Model Mech
, vol.3
, Issue.7-8
, pp. 415-419
-
-
Kaletsky, R.1
Murphy, C.T.2
-
100
-
-
77955747346
-
With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging
-
Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L (2010) With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 11 (6): 453-465. doi: 10.1016/j.cmet.2010.05.001
-
(2010)
Cell Metab
, vol.11
, Issue.6
, pp. 453-465
-
-
Kapahi, P.1
Chen, D.2
Rogers, A.N.3
Katewa, S.D.4
Li, P.W.5
Thomas, E.L.6
Kockel, L.7
-
101
-
-
0033885953
-
Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans
-
Kawano T, Ito Y, Ishiguro M, Takuwa K, Nakajima T, Kimura Y (2000) Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Biochem Biophys Res Commun 273(2): 431-436. doi: 10.1006/bbrc.2000.2971
-
(2000)
Biochem Biophys Res Commun
, vol.273
, Issue.2
, pp. 431-436
-
-
Kawano, T.1
Ito, Y.2
Ishiguro, M.3
Takuwa, K.4
Nakajima, T.5
Kimura, Y.6
-
102
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366(6454): 461-464. doi: 10.1038/366461a0
-
(1993)
Nature
, vol.366
, Issue.6454
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
103
-
-
77950200010
-
The genetics of ageing
-
Kenyon CJ (2010) The genetics of ageing. Nature 464(7288): 504-512. doi: 10.1038/nature08980
-
(2010)
Nature
, vol.464
, Issue.7288
, pp. 504-512
-
-
Kenyon, C.J.1
-
104
-
-
84886733138
-
TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants
-
Khan MH, Ligon M, Hussey LR, Hufnal B, Farber R 2nd, Munkacsy E, Rodriguez A, Dillow A, Kahlig E, Rea SL (2013) TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging 5(10): 741-758
-
(2013)
Aging
, vol.5
, Issue.10
, pp. 741-758
-
-
Khan, M.H.1
Ligon, M.2
Hussey, L.R.3
Hufnal, B.4
Farber 2nd, R.5
Munkacsy, E.6
Rodriguez, A.7
Dillow, A.8
Kahlig, E.9
Rea, S.L.10
-
105
-
-
84872847245
-
Reconciliation of daf-2 suppression by elt-3 in Caenorhabditis elegans from Tonsaker et al. (2012) and Kim et al. (2012)
-
Kim SK, Budovskaya YV, Johnson TE (2013) Reconciliation of daf-2 suppression by elt-3 in Caenorhabditis elegans from Tonsaker et al. (2012) and Kim et al. (2012). Mech Ageing Dev 134(1-2): 64-65. doi: 10.1016/j.mad.2012.12.004
-
(2013)
Mech Ageing Dev
, vol.134
, Issue.1-2
, pp. 64-65
-
-
Kim, S.K.1
Budovskaya, Y.V.2
Johnson, T.E.3
-
106
-
-
34447636066
-
Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan
-
Kim Y, Sun H (2007) Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan. Aging Cell 6(4): 489-503. doi: 10.1111/j.1474-9726.2007.00302.x
-
(2007)
Aging Cell
, vol.6
, Issue.4
, pp. 489-503
-
-
Kim, Y.1
Sun, H.2
-
107
-
-
12144264839
-
Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress
-
Lamitina ST, Strange K (2005) Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Am J Physiol Cell Physiol 288(2): C467-C474. doi: 10.1152/ajpcell.00451.2004
-
(2005)
Am J Physiol Cell Physiol
, vol.288
, Issue.2
, pp. C467-C474
-
-
Lamitina, S.T.1
Strange, K.2
-
108
-
-
0037204066
-
Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase
-
Lanjuin A, Sengupta P (2002) Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase. Neuron 33(3): 369-381
-
(2002)
Neuron
, vol.33
, Issue.3
, pp. 369-381
-
-
Lanjuin, A.1
Sengupta, P.2
-
109
-
-
33847421281
-
Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans
-
Lans H, Jansen G (2007) Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. Dev Biol 303(2): 474-482. doi: 10.1016/j.ydbio.2006.11.028
-
(2007)
Dev Biol
, vol.303
, Issue.2
, pp. 474-482
-
-
Lans, H.1
Jansen, G.2
-
110
-
-
80053312481
-
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans
-
Lapierre LR, Gelino S, Melendez A, Hansen M (2011) Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol 21(18): 1507-1514. doi: 10.1016/j.cub.2011.07.042
-
(2011)
Curr Biol
, vol.21
, Issue.18
, pp. 1507-1514
-
-
Lapierre, L.R.1
Gelino, S.2
Melendez, A.3
Hansen, M.4
-
111
-
-
84883063789
-
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
-
Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M (2013a) The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun 4: 2267. doi: 10.1038/ncomms3267
-
(2013)
Nat Commun
, vol.4
, pp. 2267
-
-
Lapierre, L.R.1
De Magalhaes Filho, C.D.2
McQuary, P.R.3
Chu, C.C.4
Visvikis, O.5
Chang, J.T.6
Gelino, S.7
Ong, B.8
Davis, A.E.9
Irazoqui, J.E.10
Dillin, A.11
Hansen, M.12
-
112
-
-
84877086717
-
Autophagy genes are required for normal lipid levels in C. elegans
-
Lapierre LR, Silvestrini MJ, Nunez L, Ames K, Wong S, Le TT, Hansen M, Melendez A (2013b) Autophagy genes are required for normal lipid levels in C. elegans. Autophagy 9(3): 278-286. doi: 10.4161/auto.22930
-
(2013)
Autophagy
, vol.9
, Issue.3
, pp. 278-286
-
-
Lapierre, L.R.1
Silvestrini, M.J.2
Nunez, L.3
Ames, K.4
Wong, S.5
Le, T.T.6
Hansen, M.7
Melendez, A.8
-
113
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149(2): 274-293. doi: 10.1016/j.cell.2012.03.017
-
(2012)
Cell
, vol.149
, Issue.2
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
114
-
-
0028930267
-
Genes that regulate both development and longevity in Caenorhabditis elegans
-
Larsen PL, Albert PS, Riddle DL (1995) Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139(4): 1567-1583
-
(1995)
Genetics
, vol.139
, Issue.4
, pp. 1567-1583
-
-
Larsen, P.L.1
Albert, P.S.2
Riddle, D.L.3
-
115
-
-
0032573178
-
The genetics of caloric restriction in Caenorhabditis elegans
-
Lakowski B, Hekimi S (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci 95(22): 13091-13096
-
(1998)
Proc Natl Acad Sci
, vol.95
, Issue.22
, pp. 13091-13096
-
-
Lakowski, B.1
Hekimi, S.2
-
116
-
-
55449120240
-
A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan
-
Lee BH, Ashrafi K (2008) A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. PLoS Genet 4(10), e1000213. doi: 10.1371/journal.pgen.1000213
-
(2008)
PLoS Genet
, vol.4
, Issue.10
, pp. 1000213
-
-
Lee, B.H.1
Ashrafi, K.2
-
117
-
-
65549165654
-
Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans
-
Lee SJ, Kenyon C (2009) Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol 19(9): 715-722. doi: 10.1016/j.cub.2009.03.041
-
(2009)
Curr Biol
, vol.19
, Issue.9
, pp. 715-722
-
-
Lee, S.J.1
Kenyon, C.2
-
118
-
-
0035846601
-
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
-
Lee RY, Hench J, Ruvkun G (2001) Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol 11(24): 1950-1957
-
(2001)
Curr Biol
, vol.11
, Issue.24
, pp. 1950-1957
-
-
Lee, R.Y.1
Hench, J.2
Ruvkun, G.3
-
119
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G (2003) A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33(1): 40-48. doi: 10.1038/ng1056
-
(2003)
Nat Genet
, vol.33
, Issue.1
, pp. 40-48
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Ruvkun, G.6
-
120
-
-
70350365110
-
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression
-
Lee SJ, Murphy CT, Kenyon C (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab 10 (5): 379-391. doi: 10.1016/j.cmet.2009.10.003
-
(2009)
Cell Metab
, vol.10
, Issue.5
, pp. 379-391
-
-
Lee, S.J.1
Murphy, C.T.2
Kenyon, C.3
-
121
-
-
78650177082
-
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity
-
Lee SJ, Hwang AB, Kenyon C (2010) Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol 20(23): 2131-2136. doi: 10.1016/j.cub.2010.10.057
-
(2010)
Curr Biol
, vol.20
, Issue.23
, pp. 2131-2136
-
-
Lee, S.J.1
Hwang, A.B.2
Kenyon, C.3
-
122
-
-
33646934067
-
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
-
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125(5): 987-1001. doi: 10.1016/j.cell.2006.03.046
-
(2006)
Cell
, vol.125
, Issue.5
, pp. 987-1001
-
-
Lehtinen, M.K.1
Yuan, Z.2
Boag, P.R.3
Yang, Y.4
Villen, J.5
Becker, E.B.6
DiBacco, S.7
De La Iglesia, N.8
Gygi, S.9
Blackwell, T.K.10
Bonni, A.11
-
123
-
-
79952582588
-
HIF-1 modulates longevity and healthspan in a temperature-dependent manner
-
Leiser SF, Begun A, Kaeberlein M (2011) HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell 10(2): 318-326. doi: 10.1111/j.1474-9726.2011.00672.x
-
(2011)
Aging Cell
, vol.10
, Issue.2
, pp. 318-326
-
-
Leiser, S.F.1
Begun, A.2
Kaeberlein, M.3
-
124
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine B, Klionsky DJ (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6(4): 463-477
-
(2004)
Dev Cell
, vol.6
, Issue.4
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
125
-
-
33845736825
-
The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans
-
Li J, Tewari M, Vidal M, Lee SS (2007a) The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev Biol 301(1): 82-91
-
(2007)
Dev Biol
, vol.301
, Issue.1
, pp. 82-91
-
-
Li, J.1
Tewari, M.2
Vidal, M.3
Lee, S.S.4
-
126
-
-
33846596646
-
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination
-
Li W, Gao B, Lee SM, Bennett K, Fang D (2007b) RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev Cell 12(2): 235-246. doi: 10.1016/j.devcel.2006.12.002
-
(2007)
Dev Cell
, vol.12
, Issue.2
, pp. 235-246
-
-
Li, W.1
Gao, B.2
Lee, S.M.3
Bennett, K.4
Fang, D.5
-
127
-
-
54749095200
-
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator
-
Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee SS (2008) Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol 6(9), e233. doi: 10.1371/journal.pbio.0060233
-
(2008)
PLoS Biol
, vol.6
, Issue.9
, pp. 233
-
-
Li, J.1
Ebata, A.2
Dong, Y.3
Rizki, G.4
Iwata, T.5
Lee, S.S.6
-
128
-
-
33847259770
-
Regulation of Drosophila life span by olfaction and food-derived odors
-
Libert S, Zwiener J, Chu X, Vanvoorhies W, Roman G, Pletcher SD (2007) Regulation of Drosophila life span by olfaction and food-derived odors. Science 315(5815): 1133-1137. doi: 10.1126/science.1136610
-
(2007)
Science
, vol.315
, Issue.5815
, pp. 1133-1137
-
-
Libert, S.1
Zwiener, J.2
Chu, X.3
Vanvoorhies, W.4
Roman, G.5
Pletcher, S.D.6
-
129
-
-
0030657540
-
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278(5341): 1319-1322
-
(1997)
Science
, vol.278
, Issue.5341
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
130
-
-
0034967720
-
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
-
Lin K, Hsin H, Libina N, Kenyon C (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 28(2): 139-145. doi: 10.1038/88850
-
(2001)
Nat Genet
, vol.28
, Issue.2
, pp. 139-145
-
-
Lin, K.1
Hsin, H.2
Libina, N.3
Kenyon, C.4
-
131
-
-
80054018891
-
Sensory perception and aging in model systems: From the outside in
-
Linford NJ, Kuo TH, Chan TP, Pletcher SD (2011) Sensory perception and aging in model systems: from the outside in. Annu Rev Cell Dev Biol 27: 759-785. doi: 10.1146/annurevcellbio-092910-154240
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 759-785
-
-
Linford, N.J.1
Kuo, T.H.2
Chan, T.P.3
Pletcher, S.D.4
-
132
-
-
0029123058
-
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
-
Lithgow GJ, White TM, Melov S, Johnson TE (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A 92 (16): 7540-7544
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.16
, pp. 7540-7544
-
-
Lithgow, G.J.1
White, T.M.2
Melov, S.3
Johnson, T.E.4
-
133
-
-
79959981053
-
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans
-
Lithgow GJ, Kapahi P (2011) Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab 14(1): 55-66. doi: 10.1016/j.cmet.2011.05.010
-
(2011)
Cell Metab
, vol.14
, Issue.1
, pp. 55-66
-
-
Lithgow, G.J.1
Kapahi, P.2
-
134
-
-
79955910864
-
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans
-
Lucanic M, Held JM, Vantipalli MC, Klang IM, Graham JB, Gibson BW, Lithgow GJ, Gill MS (2011) N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature 473(7346): 226-229. doi: 10.1038/nature10007
-
(2011)
Nature
, vol.473
, Issue.7346
, pp. 226-229
-
-
Lucanic, M.1
Held, J.M.2
Vantipalli, M.C.3
Klang, I.M.4
Graham, J.B.5
Gibson, B.W.6
Lithgow, G.J.7
Gill, M.S.8
-
135
-
-
84881337582
-
The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans
-
Magner DB, Wollam J, Shen Y, Hoppe C, Li D, Latza C, Rottiers V, Hutter H, Antebi A (2013) The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans. Cell Metab 18(2): 212-224. doi: 10.1016/j.cmet.2013.07.007
-
(2013)
Cell Metab
, vol.18
, Issue.2
, pp. 212-224
-
-
Magner, D.B.1
Wollam, J.2
Shen, Y.3
Hoppe, C.4
Li, D.5
Latza, C.6
Rottiers, V.7
Hutter, H.8
Antebi, A.9
-
136
-
-
84891876815
-
Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan
-
Mahanti P, Bose N, Bethke A, Judkins JC, Wollam J, Dumas KJ, Zimmerman AM, Campbell SL, Hu PJ, Antebi A, Schroeder FC (2014) Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab 19(1): 73-83. doi: 10.1016/j.cmet.2013.11.024
-
(2014)
Cell Metab
, vol.19
, Issue.1
, pp. 73-83
-
-
Mahanti, P.1
Bose, N.2
Bethke, A.3
Judkins, J.C.4
Wollam, J.5
Dumas, K.J.6
Zimmerman, A.M.7
Campbell, S.L.8
Hu, P.J.9
Antebi, A.10
Schroeder, F.C.11
-
137
-
-
77952908744
-
A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan
-
Maier W, Adilov B, Regenass M, Alcedo J (2010) A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol 8(5), e1000376. doi: 10.1371/journal.pbio.1000376
-
(2010)
PLoS Biol
, vol.8
, Issue.5
, pp. 1000376
-
-
Maier, W.1
Adilov, B.2
Regenass, M.3
Alcedo, J.4
-
138
-
-
0030007767
-
Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans Dauer formation
-
Malone EA, Inoue T, Thomas JH (1996) Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans Dauer formation. Genetics 143(3): 1193-1205
-
(1996)
Genetics
, vol.143
, Issue.3
, pp. 1193-1205
-
-
Malone, E.A.1
Inoue, T.2
Thomas, J.H.3
-
139
-
-
25844512127
-
Lifespan and Dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18
-
Masse I, Molin L, Billaud M, Solari F (2005) Lifespan and Dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. Dev Biol 286(1): 91-101. doi: 10.1016/j.ydbio.2005.07.010
-
(2005)
Dev Biol
, vol.286
, Issue.1
, pp. 91-101
-
-
Masse, I.1
Molin, L.2
Billaud, M.3
Solari, F.4
-
140
-
-
84863328610
-
Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18
-
Matsunaga Y, Gengyo-Ando K, Mitani S, Iwasaki T, Kawano T (2012) Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18. Biochem Biophys Res Commun 423(3): 478-483. doi: 10.1016/j.bbrc.2012.05.145
-
(2012)
Biochem Biophys Res Commun
, vol.423
, Issue.3
, pp. 478-483
-
-
Matsunaga, Y.1
Gengyo-Ando, K.2
Mitani, S.3
Iwasaki, T.4
Kawano, T.5
-
141
-
-
81155139577
-
The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner
-
Maures TJ, Greer EL, Hauswirth AG, Brunet A (2011) The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. Aging Cell 10 (6): 980-990. doi: 10.1111/j.1474-9726.2011.00738.x
-
(2011)
Aging Cell
, vol.10
, Issue.6
, pp. 980-990
-
-
Maures, T.J.1
Greer, E.L.2
Hauswirth, A.G.3
Brunet, A.4
-
142
-
-
84858341125
-
New genes that extend Caenorhabditis elegans’ lifespan in response to reproductive signals
-
McCormick M, Chen K, Ramaswamy P, Kenyon C (2012) New genes that extend Caenorhabditis elegans’ lifespan in response to reproductive signals. Aging Cell 11(2): 192-202. doi: 10.1111/j.1474-9726.2011.00768.x
-
(2012)
Aging Cell
, vol.11
, Issue.2
, pp. 192-202
-
-
McCormick, M.1
Chen, K.2
Ramaswamy, P.3
Kenyon, C.4
-
143
-
-
66349098677
-
Proteasomal regulation of the hypoxic response modulates aging in C. elegans
-
Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M (2009) Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324(5931): 1196-1198. doi: 10.1126/science.1173507
-
(2009)
Science
, vol.324
, Issue.5931
, pp. 1196-1198
-
-
Mehta, R.1
Steinkraus, K.A.2
Sutphin, G.L.3
Ramos, F.J.4
Shamieh, L.S.5
Huh, A.6
Davis, C.7
Chandler-Brown, D.8
Kaeberlein, M.9
-
144
-
-
0042691506
-
Autophagy genes are essential for Dauer development and life-span extension in C. elegans
-
Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B (2003) Autophagy genes are essential for Dauer development and life-span extension in C. elegans. Science 301 (5638): 1387-1391. doi: 10.1126/science.1087782
-
(2003)
Science
, vol.301
, Issue.5638
, pp. 1387-1391
-
-
Melendez, A.1
Talloczy, Z.2
Seaman, M.3
Eskelinen, E.L.4
Hall, D.H.5
Levine, B.6
-
145
-
-
0033595003
-
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and Dauer formation in an insulin receptor-like signaling pathway
-
Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, Sun H (1999) The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and Dauer formation in an insulin receptor-like signaling pathway. Proc Natl Acad Sci U S A 96(13): 7427-7432
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.13
, pp. 7427-7432
-
-
Mihaylova, V.T.1
Borland, C.Z.2
Manjarrez, L.3
Stern, M.J.4
Sun, H.5
-
146
-
-
0742323000
-
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
-
Morley JF, Morimoto RI (2004) Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell 15(2): 657-664. doi: 10.1091/mbc.E03-07-0532
-
(2004)
Mol Biol Cell
, vol.15
, Issue.2
, pp. 657-664
-
-
Morley, J.F.1
Morimoto, R.I.2
-
147
-
-
0036678146
-
The threshold for polyglutamineexpansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
Morley JF, Brignull HR, Weyers JJ, Morimoto RI (2002) The threshold for polyglutamineexpansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A 99(16): 10417-10422. doi: 10.1073/pnas.152161099
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.16
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
148
-
-
84911447491
-
Dietary restriction involves NAD(+) -dependent mechanisms and a shift toward oxidative metabolism
-
Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK (2014) Dietary restriction involves NAD(+) -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell 13(6): 1075-1085. doi: 10.1111/acel.12273
-
(2014)
Aging Cell
, vol.13
, Issue.6
, pp. 1075-1085
-
-
Moroz, N.1
Carmona, J.J.2
Anderson, E.3
Hart, A.C.4
Sinclair, D.A.5
Blackwell, T.K.6
-
149
-
-
0029768753
-
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382(6591): 536-539. doi: 10.1038/382536a0
-
(1996)
Nature
, vol.382
, Issue.6591
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
150
-
-
33646042547
-
Identification of ligands for DAF-12 that govern Dauer formation and reproduction in C. elegans
-
Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ (2006) Identification of ligands for DAF-12 that govern Dauer formation and reproduction in C. elegans. Cell 124(6): 1209-1223. doi: http://dx.doi.org/10.1016/j.cell.2006.01.037
-
(2006)
Cell
, vol.124
, Issue.6
, pp. 1209-1223
-
-
Motola, D.L.1
Cummins, C.L.2
Rottiers, V.3
Sharma, K.K.4
Li, T.5
Li, Y.6
Suino-Powell, K.7
Xu, H.E.8
Auchus, R.J.9
Antebi, A.10
Mangelsdorf, D.J.11
-
151
-
-
84880517634
-
The NAD(+)/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
-
Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Canto C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J (2013) The NAD(+)/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154 (2): 430-441. doi: 10.1016/j.cell.2013.06.016
-
(2013)
Cell
, vol.154
, Issue.2
, pp. 430-441
-
-
Mouchiroud, L.1
Houtkooper, R.H.2
Moullan, N.3
Katsyuba, E.4
Ryu, D.5
Canto, C.6
Mottis, A.7
Jo, Y.S.8
Viswanathan, M.9
Schoonjans, K.10
Guarente, L.11
Auwerx, J.12
-
152
-
-
27244443371
-
C. elegans tubby regulates life span and fat storage by two independent mechanisms
-
Mukhopadhyay A, Deplancke B, Walhout AJ, Tissenbaum HA (2005) C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metab 2(1): 35-42. doi: 10.1016/j.cmet.2005.06.004
-
(2005)
Cell Metab
, vol.2
, Issue.1
, pp. 35-42
-
-
Mukhopadhyay, A.1
Deplancke, B.2
Walhout, A.J.3
Tissenbaum, H.A.4
-
153
-
-
72049106682
-
The von Hippel Lindau tumor suppressor limits longevity
-
Muller RU, Fabretti F, Zank S, Burst V, Benzing T, Schermer B (2009) The von Hippel Lindau tumor suppressor limits longevity. J Am Soc Nephrol 20(12): 2513-2517. doi: 10.1681/asn.2009050497
-
(2009)
J Am Soc Nephrol
, vol.20
, Issue.12
, pp. 2513-2517
-
-
Muller, R.U.1
Fabretti, F.2
Zank, S.3
Burst, V.4
Benzing, T.5
Schermer, B.6
-
154
-
-
84916203269
-
Insulin/insulin-like growth factor signaling in C. elegans
-
Murphy CT, Hu PJ (2013) Insulin/insulin-like growth factor signaling in C. elegans. WormBook: 1-43. doi: 10.1895/wormbook.1.164.1
-
(2013)
WormBook
, pp. 1-43
-
-
Murphy, C.T.1
Hu, P.J.2
-
155
-
-
37649022616
-
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
-
Murphy CT, Lee SJ, Kenyon C (2007) Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A 104 (48): 19046-19050. doi: 10.1073/pnas.0709613104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.48
, pp. 19046-19050
-
-
Murphy, C.T.1
Lee, S.J.2
Kenyon, C.3
-
156
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424(6946): 277-283. doi: 10.1038/nature01789
-
(2003)
Nature
, vol.424
, Issue.6946
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
157
-
-
27744468105
-
LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans
-
Nanji M, Hopper NA, Gems D (2005) LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans. Aging Cell 4(5): 235-245. doi: 10.1111/j.1474-9726.2005.00166.x
-
(2005)
Aging Cell
, vol.4
, Issue.5
, pp. 235-245
-
-
Nanji, M.1
Hopper, N.A.2
Gems, D.3
-
158
-
-
53549131261
-
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans
-
Neumann-Haefelin E, Qi W, Finkbeiner E, Walz G, Baumeister R, Hertweck M (2008) SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. Genes Dev 22(19): 2721-2735. doi: 10.1101/gad.478408
-
(2008)
Genes Dev
, vol.22
, Issue.19
, pp. 2721-2735
-
-
Neumann-Haefelin, E.1
Qi, W.2
Finkbeiner, E.3
Walz, G.4
Baumeister, R.5
Hertweck, M.6
-
159
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389(6654): 994-999. doi: 10.1038/40194
-
(1997)
Nature
, vol.389
, Issue.6654
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
160
-
-
15444371989
-
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
-
Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA (2005) JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A 102(12): 4494-4499. doi: 10.1073/pnas.0500749102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.12
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
Jiang, F.4
Davis, R.J.5
Tissenbaum, H.A.6
-
161
-
-
77956919284
-
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans
-
Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, Hisamoto N, Matsumoto K, Nishida E (2010) The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem 285(39): 30274-30281. doi: 10.1074/jbc.M110.146274
-
(2010)
J Biol Chem
, vol.285
, Issue.39
, pp. 30274-30281
-
-
Okuyama, T.1
Inoue, H.2
Ookuma, S.3
Satoh, T.4
Kano, K.5
Honjoh, S.6
Hisamoto, N.7
Matsumoto, K.8
Nishida, E.9
-
162
-
-
84878533962
-
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
-
O’Rourke EJ, Ruvkun G (2013) MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol 15(6): 668-676. doi: 10.1038/ncb2741
-
(2013)
Nat Cell Biol
, vol.15
, Issue.6
, pp. 668-676
-
-
O’Rourke, E.J.1
Ruvkun, G.2
-
163
-
-
70350365111
-
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles
-
O’Rourke EJ, Soukas AA, Carr CE, Ruvkun G (2009) C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab 10(5): 430-435. doi: 10.1016/j.cmet.2009.10.002
-
(2009)
Cell Metab
, vol.10
, Issue.5
, pp. 430-435
-
-
O’Rourke, E.J.1
Soukas, A.A.2
Carr, C.E.3
Ruvkun, G.4
-
164
-
-
61349123235
-
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation
-
Padmanabhan S, Mukhopadhyay A, Narasimhan SD, Tesz G, Czech MP, Tissenbaum HA (2009) A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell 136(5): 939-951. doi: 10.1016/j.cell.2009.01.025
-
(2009)
Cell
, vol.136
, Issue.5
, pp. 939-951
-
-
Padmanabhan, S.1
Mukhopadhyay, A.2
Narasimhan, S.D.3
Tesz, G.4
Czech, M.P.5
Tissenbaum, H.A.6
-
165
-
-
84867040616
-
Mitochondrial SKN-1/Nrf mediates a conserved starvation response
-
Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP (2012) Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab 16(4): 526-537. doi: 10.1016/j.cmet.2012.09.007
-
(2012)
Cell Metab
, vol.16
, Issue.4
, pp. 526-537
-
-
Paek, J.1
Lo, J.Y.2
Narasimhan, S.D.3
Nguyen, T.N.4
Glover-Cutter, K.5
Robida-Stubbs, S.6
Suzuki, T.7
Yamamoto, M.8
Blackwell, T.K.9
Curran, S.P.10
-
166
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6(1): 111-119. doi: 10.1111/j.1474-9726.2006.00266.x
-
(2007)
Aging Cell
, vol.6
, Issue.1
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
Lithgow, G.J.6
Kapahi, P.7
-
167
-
-
34249888736
-
PHA-4/Foxa mediates dietrestriction-induced longevity of C. elegans
-
Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A (2007) PHA-4/Foxa mediates dietrestriction-induced longevity of C. elegans. Nature 447(7144): 550-555. doi: 10.1038/nature05837
-
(2007)
Nature
, vol.447
, Issue.7144
, pp. 550-555
-
-
Panowski, S.H.1
Wolff, S.2
Aguilaniu, H.3
Durieux, J.4
Dillin, A.5
-
168
-
-
0033151613
-
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
-
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G (1999) A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13(11): 1438-1452
-
(1999)
Genes Dev
, vol.13
, Issue.11
, pp. 1438-1452
-
-
Paradis, S.1
Ailion, M.2
Toker, A.3
Thomas, J.H.4
Ruvkun, G.5
-
169
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
Paradis S, Ruvkun G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12(16): 2488-2498
-
(1998)
Genes Dev
, vol.12
, Issue.16
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
170
-
-
76149095203
-
Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans
-
Park SK, Link CD, Johnson TE (2010) Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J 24(2): 383-392. doi: 10.1096/fj.09-142984, fj.09-142984 [pii]
-
(2010)
FASEB J
, vol.24
, Issue.2
, pp. 383-392
-
-
Park, S.K.1
Link, C.D.2
Johnson, T.E.3
-
171
-
-
36549006956
-
An antidepressant that extends lifespan in adult Caenorhabditis elegans
-
Petrascheck M, Ye X, Buck LB (2007) An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450(7169): 553-556
-
(2007)
Nature
, vol.450
, Issue.7169
, pp. 553-556
-
-
Petrascheck, M.1
Ye, X.2
Buck, L.B.3
-
172
-
-
0035868890
-
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
-
Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G (2001) Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 15(6): 672-686. doi: 10.1101/gad.867301
-
(2001)
Genes Dev
, vol.15
, Issue.6
, pp. 672-686
-
-
Pierce, S.B.1
Costa, M.2
Wisotzkey, R.3
Devadhar, S.4
Homburger, S.A.5
Buchman, A.R.6
Ferguson, K.C.7
Heller, J.8
Platt, D.M.9
Pasquinelli, A.A.10
Liu, L.X.11
Doberstein, S.K.12
Ruvkun, G.13
-
173
-
-
79960939173
-
Dietary restriction and aging: A unifying perspective
-
Piper MD, Partridge L, Raubenheimer D, Simpson SJ (2011) Dietary restriction and aging: a unifying perspective. Cell Metab 14(2): 154-160. doi: 10.1016/j.cmet.2011.06.013
-
(2011)
Cell Metab
, vol.14
, Issue.2
, pp. 154-160
-
-
Piper, M.D.1
Partridge, L.2
Raubenheimer, D.3
Simpson, S.J.4
-
174
-
-
84901305990
-
Folliculin regulates ampk-dependent autophagy and metabolic stress survival
-
Possik E, Jalali Z, Nouet Y, Yan M, Gingras MC, Schmeisser K, Panaite L, Dupuy F, Kharitidi D, Chotard L, Jones RG, Hall DH, Pause A (2014) Folliculin regulates ampk-dependent autophagy and metabolic stress survival. PLoS Genet 10(4), e1004273. doi: 10.1371/journal.pgen.1004273
-
(2014)
PLoS Genet
, vol.10
, Issue.4
, pp. 1004273
-
-
Possik, E.1
Jalali, Z.2
Nouet, Y.3
Yan, M.4
Gingras, M.C.5
Schmeisser, K.6
Panaite, L.7
Dupuy, F.8
Kharitidi, D.9
Chotard, L.10
Jones, R.G.11
Hall, D.H.12
Pause, A.13
-
175
-
-
77954310408
-
Hypoxia signaling and resistance in C. elegans
-
Powell-Coffman JA (2010) Hypoxia signaling and resistance in C. elegans. Trends Endocrinol Metab 21(7): 435-440. doi: 10.1016/j.tem.2010.02.006
-
(2010)
Trends Endocrinol Metab
, vol.21
, Issue.7
, pp. 435-440
-
-
Powell-Coffman, J.A.1
-
176
-
-
79954500148
-
Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans
-
Rahman MM, Stuchlick O, El-Karim EG, Stuart R, Kipreos ET, Wells L (2010) Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Aging 2(10): 678-690
-
(2010)
Aging
, vol.2
, Issue.10
, pp. 678-690
-
-
Rahman, M.M.1
Stuchlick, O.2
El-Karim, E.G.3
Stuart, R.4
Kipreos, E.T.5
Wells, L.6
-
177
-
-
84919608396
-
Germline signals deploy NHR-49 to modulate fatty-acid beta-oxidation and desaturation in somatic tissues of C. elegans
-
Ratnappan R, Amrit FR, Chen SW, Gill H, Holden K, Ward J, Yamamoto KR, Olsen CP, Ghazi A (2014) Germline signals deploy NHR-49 to modulate fatty-acid beta-oxidation and desaturation in somatic tissues of C. elegans. PLoS Genet 10(12), e1004829. doi: 10.1371/journal.pgen.1004829
-
(2014)
PLoS Genet
, vol.10
, Issue.12
, pp. 1004829
-
-
Ratnappan, R.1
Amrit, F.R.2
Chen, S.W.3
Gill, H.4
Holden, K.5
Ward, J.6
Yamamoto, K.R.7
Olsen, C.P.8
Ghazi, A.9
-
178
-
-
35648947912
-
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
-
Rea SL, Ventura N, Johnson TE (2007) Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol 5 (10), e259. doi: 10.1371/journal.pbio.0050259
-
(2007)
PLoS Biol
, vol.5
, Issue.10
, pp. 259
-
-
Rea, S.L.1
Ventura, N.2
Johnson, T.E.3
-
179
-
-
84901291766
-
TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling
-
Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A (2014) TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. Cell 157(5): 1023-1036. doi: 10.1016/j.cell.2014.03.051
-
(2014)
Cell
, vol.157
, Issue.5
, pp. 1023-1036
-
-
Riera, C.E.1
Huising, M.O.2
Follett, P.3
Leblanc, M.4
Halloran, J.5
Van Andel, R.6
De Magalhaes Filho, C.D.7
Merkwirth, C.8
Dillin, A.9
-
180
-
-
80053460544
-
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
-
Rizki G, Iwata TN, Li J, Riedel CG, Picard CL, Jan M, Murphy CT, Lee SS (2011) The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet 7(9), e1002235. doi: 10.1371/journal.pgen.1002235
-
(2011)
PLoS Genet
, vol.7
, Issue.9
, pp. 1002235
-
-
Rizki, G.1
Iwata, T.N.2
Li, J.3
Riedel, C.G.4
Picard, C.L.5
Jan, M.6
Murphy, C.T.7
Lee, S.S.8
-
181
-
-
84860461929
-
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
-
Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab 15(5): 713-724. doi: 10.1016/j.cmet.2012.04.007
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 713-724
-
-
Robida-Stubbs, S.1
Glover-Cutter, K.2
Lamming, D.W.3
Mizunuma, M.4
Narasimhan, S.D.5
Neumann-Haefelin, E.6
Sabatini, D.M.7
Blackwell, T.K.8
-
182
-
-
79959981053
-
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans
-
Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P (2011) Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab 14(1): 55-66. doi: 10.1016/j.cmet.2011.05.010
-
(2011)
Cell Metab
, vol.14
, Issue.1
, pp. 55-66
-
-
Rogers, A.N.1
Chen, D.2
McColl, G.3
Czerwieniec, G.4
Felkey, K.5
Gibson, B.W.6
Hubbard, A.7
Melov, S.8
Lithgow, G.J.9
Kapahi, P.10
-
183
-
-
33645527191
-
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase
-
Rottiers V, Motola DL, Gerisch B, Cummins CL, Nishiwaki K, Mangelsdorf DJ, Antebi A (2006) Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev Cell 10(4): 473-482. doi: 10.1016/j.devcel.2006.02.008
-
(2006)
Dev Cell
, vol.10
, Issue.4
, pp. 473-482
-
-
Rottiers, V.1
Motola, D.L.2
Gerisch, B.3
Cummins, C.L.4
Nishiwaki, K.5
Mangelsdorf, D.J.6
Antebi, A.7
-
184
-
-
48249110913
-
Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains
-
Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G (2007) Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol 72: 489-497. doi: 10.1101/sqb.2007.72.068
-
(2007)
Cold Spring Harb Symp Quant Biol
, vol.72
, pp. 489-497
-
-
Samuelson, A.V.1
Klimczak, R.R.2
Thompson, D.B.3
Carr, C.E.4
Ruvkun, G.5
-
185
-
-
84872566075
-
Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans
-
Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condo I, Bei R, Rea SL, Braeckman BP, Tavernarakis N, Testi R, Ventura N (2013) Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol 48(2): 191-201. doi: 10.1016/j.exger.2012.12.002
-
(2013)
Exp Gerontol
, vol.48
, Issue.2
, pp. 191-201
-
-
Schiavi, A.1
Torgovnick, A.2
Kell, A.3
Megalou, E.4
Castelein, N.5
Guccini, I.6
Marzocchella, L.7
Gelino, S.8
Hansen, M.9
Malisan, F.10
Condo, I.11
Bei, R.12
Rea, S.L.13
Braeckman, B.P.14
Tavernarakis, N.15
Testi, R.16
Ventura, N.17
-
186
-
-
84886476382
-
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
-
Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol 9(11): 693-700. doi: 10.1038/nchembio.1352
-
(2013)
Nat Chem Biol
, vol.9
, Issue.11
, pp. 693-700
-
-
Schmeisser, K.1
Mansfeld, J.2
Kuhlow, D.3
Weimer, S.4
Priebe, S.5
Heiland, I.6
Birringer, M.7
Groth, M.8
Segref, A.9
Kanfi, Y.10
Price, N.L.11
Schmeisser, S.12
Schuster, S.13
Pfeiffer, A.F.14
Guthke, R.15
Platzer, M.16
Hoppe, T.17
Cohen, H.Y.18
Zarse, K.19
Sinclair, D.A.20
Ristow, M.21
more..
-
187
-
-
77953186247
-
Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1
-
Schreiber MA, Pierce-Shimomura JT, Chan S, Parry D, McIntire SL (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet 6(5), e1000972. doi: 10.1371/journal.pgen.1000972
-
(2010)
PLoS Genet
, vol.6
, Issue.5
, pp. 1000972
-
-
Schreiber, M.A.1
Pierce-Shimomura, J.T.2
Chan, S.3
Parry, D.4
McIntire, S.L.5
-
188
-
-
0037189303
-
Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2
-
Scott BA, Avidan MS, Crowder CM (2002) Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science 296(5577): 2388-2391. doi: 10.1126/science.1072302
-
(2002)
Science
, vol.296
, Issue.5577
, pp. 2388-2391
-
-
Scott, B.A.1
Avidan, M.S.2
Crowder, C.M.3
-
189
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326 (5949): 140-144. doi: 10.1126/science.1177221
-
(2009)
Science
, vol.326
, Issue.5949
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
Claret, M.7
Al-Qassab, H.8
Carmignac, D.9
Ramadani, F.10
Woods, A.11
Robinson, I.C.12
Schuster, E.13
Batterham, R.L.14
Kozma, S.C.15
Thomas, G.16
Carling, D.17
Okkenhaug, K.18
Thornton, J.M.19
Partridge, L.20
Gems, D.21
Withers, D.J.22
more..
-
190
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148(3): 399-408. doi: 10.1016/j.cell.2012.01.021
-
(2012)
Cell
, vol.148
, Issue.3
, pp. 399-408
-
-
Semenza, G.L.1
-
191
-
-
84888134171
-
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans
-
Seo K, Choi E, Lee D, Jeong DE, Jang SK, Lee SJ (2013) Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell 12(6): 1073-1081. doi: 10.1111/acel.12140
-
(2013)
Aging Cell
, vol.12
, Issue.6
, pp. 1073-1081
-
-
Seo, K.1
Choi, E.2
Lee, D.3
Jeong, D.E.4
Jang, S.K.5
Lee, S.J.6
-
192
-
-
34848868499
-
The C. elegans TGF-beta dauer pathway regulates longevity via insulin signaling
-
Shaw WM, Luo S, Landis J, Ashraf J, Murphy CT (2007) The C. elegans TGF-beta dauer pathway regulates longevity via insulin signaling. Curr Biol 17(19): 1635-1645. doi: 10.1016/j.cub.2007.08.058
-
(2007)
Curr Biol
, vol.17
, Issue.19
, pp. 1635-1645
-
-
Shaw, W.M.1
Luo, S.2
Landis, J.3
Ashraf, J.4
Murphy, C.T.5
-
193
-
-
52049093450
-
The target of rapamycin pathway antagonizes pha-4/FoxA to control development and aging
-
Sheaffer KL, Updike DL, Mango SE (2008) The target of rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr Biol 18(18): 1355-1364. doi: 10.1016/j.cub.2008.07.097
-
(2008)
Curr Biol
, vol.18
, Issue.18
, pp. 1355-1364
-
-
Sheaffer, K.L.1
Updike, D.L.2
Mango, S.E.3
-
194
-
-
84871101784
-
A steroid receptor-microRNA switch regulates life span in response to signals from the gonad
-
Shen Y, Wollam J, Magner D, Karalay O, Antebi A (2012) A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. Science 338(6113): 1472-1476. doi: 10.1126/science.1228967
-
(2012)
Science
, vol.338
, Issue.6113
, pp. 1472-1476
-
-
Shen, Y.1
Wollam, J.2
Magner, D.3
Karalay, O.4
Antebi, A.5
-
195
-
-
84908179554
-
MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors
-
Smith-Vikos T, de Lencastre A, Inukai S, Shlomchik M, Holtrup B, Slack FJ (2014) MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors. Curr Biol 24(19): 2238-2246. doi: 10.1016/j.cub.2014.08.013
-
(2014)
Curr Biol
, vol.24
, Issue.19
, pp. 2238-2246
-
-
Smith-Vikos, T.1
De Lencastre, A.2
Inukai, S.3
Shlomchik, M.4
Holtrup, B.5
Slack, F.J.6
-
196
-
-
61449244533
-
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
-
Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G (2009) Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev 23(4): 496-511. doi: 10.1101/gad.1775409
-
(2009)
Genes Dev
, vol.23
, Issue.4
, pp. 496-511
-
-
Soukas, A.A.1
Kane, E.A.2
Carr, C.E.3
Melo, J.A.4
Ruvkun, G.5
-
197
-
-
69949084209
-
The TOR pathway comes of age
-
Stanfel MN, Shamieh LS, Kaeberlein M, Kennedy BK (2009) The TOR pathway comes of age. Biochim Biophys Acta 1790(10): 1067-1074. doi: 10.1016/j.bbagen.2009.06.007
-
(2009)
Biochim Biophys Acta
, vol.1790
, Issue.10
, pp. 1067-1074
-
-
Stanfel, M.N.1
Shamieh, L.S.2
Kaeberlein, M.3
Kennedy, B.K.4
-
198
-
-
43449138491
-
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
-
Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M (2008) Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7(3): 394-404. doi: 10.1111/j.1474-9726.2008.00385.x
-
(2008)
Aging Cell
, vol.7
, Issue.3
, pp. 394-404
-
-
Steinkraus, K.A.1
Smith, E.D.2
Davis, C.3
Carr, D.4
Pendergrass, W.R.5
Sutphin, G.L.6
Kennedy, B.K.7
Kaeberlein, M.8
-
199
-
-
33847199335
-
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
-
Syntichaki P, Troulinaki K, Tavernarakis N (2007) eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445(7130): 922-926. doi: 10.1038/nature05603
-
(2007)
Nature
, vol.445
, Issue.7130
, pp. 922-926
-
-
Syntichaki, P.1
Troulinaki, K.2
Tavernarakis, N.3
-
200
-
-
79955608146
-
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16
-
Takahashi Y, Daitoku H, Hirota K, Tamiya H, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Shimada T, Watanabe S, Yamagata K, Yasuda K, Ishii N, Fukamizu A (2011) Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metab 13(5): 505-516. doi: 10.1016/j.cmet.2011.03.017
-
(2011)
Cell Metab
, vol.13
, Issue.5
, pp. 505-516
-
-
Takahashi, Y.1
Daitoku, H.2
Hirota, K.3
Tamiya, H.4
Yokoyama, A.5
Kako, K.6
Nagashima, Y.7
Nakamura, A.8
Shimada, T.9
Watanabe, S.10
Yamagata, K.11
Yasuda, K.12
Ishii, N.13
Fukamizu, A.14
-
201
-
-
84879343155
-
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity
-
Taylor RC, Dillin A (2013) XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell 153(7): 1435-1447. doi: 10.1016/j.cell.2013.05.042
-
(2013)
Cell
, vol.153
, Issue.7
, pp. 1435-1447
-
-
Taylor, R.C.1
Dillin, A.2
-
202
-
-
84881175076
-
PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity
-
Tepper RG, Ashraf J, Kaletsky R, Kleemann G, Murphy CT, Bussemaker HJ (2013) PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell 154(3): 676-690. doi: 10.1016/j.cell.2013.07.006
-
(2013)
Cell
, vol.154
, Issue.3
, pp. 676-690
-
-
Tepper, R.G.1
Ashraf, J.2
Kaletsky, R.3
Kleemann, G.4
Murphy, C.T.5
Bussemaker, H.J.6
-
203
-
-
84923315335
-
Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans
-
Thondamal M, Witting M, Schmitt-Kopplin P, Aguilaniu H (2014) Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans. Nat Commun 5: 4879. doi: 10.1038/ncomms5879
-
(2014)
Nat Commun
, vol.5
, pp. 4879
-
-
Thondamal, M.1
Witting, M.2
Schmitt-Kopplin, P.3
Aguilaniu, H.4
-
204
-
-
78049425268
-
ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans
-
Thyagarajan B, Blaszczak AG, Chandler KJ, Watts JL, Johnson WE, Graves BJ (2010) ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. PLoS Genet 6(9), e1001125. doi: 10.1371/journal.pgen.1001125
-
(2010)
PLoS Genet
, vol.6
, Issue.9
, pp. 1001125
-
-
Thyagarajan, B.1
Blaszczak, A.G.2
Chandler, K.J.3
Watts, J.L.4
Johnson, W.E.5
Graves, B.J.6
-
205
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum HA, Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410(6825): 227-230. doi: 10.1038/35065638
-
(2001)
Nature
, vol.410
, Issue.6825
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
206
-
-
84856228489
-
Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans
-
Tonsaker T, Pratt RM, McGhee JD (2012) Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans. Mech Ageing Dev 133(1): 50-53. doi: 10.1016/j.mad.2011.09.006
-
(2012)
Mech Ageing Dev
, vol.133
, Issue.1
, pp. 50-53
-
-
Tonsaker, T.1
Pratt, R.M.2
McGhee, J.D.3
-
207
-
-
77953356853
-
A role for p53 in mitochondrial stress response control of longevity in C. elegans
-
Torgovnick A, Schiavi A, Testi R, Ventura N (2010) A role for p53 in mitochondrial stress response control of longevity in C. elegans. Exp Gerontol 45(7-8): 550-557. doi: 10.1016/j.exger.2010.02.007
-
(2010)
Exp Gerontol
, vol.45
, Issue.7-8
, pp. 550-557
-
-
Torgovnick, A.1
Schiavi, A.2
Testi, R.3
Ventura, N.4
-
208
-
-
41449102024
-
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans
-
Toth ML, Sigmond T, Borsos E, Barna J, Erdelyi P, Takacs-Vellai K, Orosz L, Kovacs AL, Csikos G, Sass M, Vellai T (2008) Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy 4(3): 330-338
-
(2008)
Autophagy
, vol.4
, Issue.3
, pp. 330-338
-
-
Toth, M.L.1
Sigmond, T.2
Borsos, E.3
Barna, J.4
Erdelyi, P.5
Takacs-Vellai, K.6
Orosz, L.7
Kovacs, A.L.8
Csikos, G.9
Sass, M.10
Vellai, T.11
-
209
-
-
0035943727
-
Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span
-
Tsang WY, Sayles LC, Grad LI, Pilgrim DB, Lemire BD (2001) Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. J Biol Chem 276(34): 32240-32246. doi: 10.1074/jbc.M103999200
-
(2001)
J Biol Chem
, vol.276
, Issue.34
, pp. 32240-32246
-
-
Tsang, W.Y.1
Sayles, L.C.2
Grad, L.I.3
Pilgrim, D.B.4
Lemire, B.D.5
-
210
-
-
84901741224
-
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans
-
Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D (2014) DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet 10(2), e1004109. doi: 10.1371/journal.pgen.1004109
-
(2014)
PLoS Genet
, vol.10
, Issue.2
, pp. 1004109
-
-
Tullet, J.M.1
Araiz, C.2
Sanders, M.J.3
Au, C.4
Benedetto, A.5
Papatheodorou, I.6
Clark, E.7
Schmeisser, K.8
Jones, D.9
Schuster, E.F.10
Thornton, J.M.11
Gems, D.12
-
211
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132(6): 1025-1038. doi: 10.1016/j.cell.2008.01.030
-
(2008)
Cell
, vol.132
, Issue.6
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
212
-
-
34247166642
-
The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival
-
van der Horst A, Schavemaker JM, Pellis-van Berkel W, Burgering BM (2007) The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival. Mech Ageing Dev 128 (4): 346-349. doi: 10.1016/j.mad.2007.01.004
-
(2007)
Mech Ageing Dev
, vol.128
, Issue.4
, pp. 346-349
-
-
Van Der Horst, A.1
Schavemaker, J.M.2
Pellis-Van Berkel, W.3
Burgering, B.M.4
-
213
-
-
15744386624
-
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans
-
Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3(2), e53. doi: 10.1371/journal.pbio.0030053
-
(2005)
PLoS Biol
, vol.3
, Issue.2
, pp. 53
-
-
Van Gilst, M.R.1
Hadjivassiliou, H.2
Jolly, A.3
Yamamoto, K.R.4
-
214
-
-
61449184625
-
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
-
Van Raamsdonk JM, Hekimi S (2009) Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 5(2), e1000361. doi: 10.1371/journal.pgen.1000361
-
(2009)
PLoS Genet
, vol.5
, Issue.2
, pp. 1000361
-
-
Van Raamsdonk, J.M.1
Hekimi, S.2
-
215
-
-
84859575436
-
Superoxide dismutase is dispensable for normal animal lifespan
-
Van Raamsdonk JM, Hekimi S (2012) Superoxide dismutase is dispensable for normal animal lifespan. Proc Natl Acad Sci U S A 109(15): 5785-5790. doi: 10.1073/pnas.1116158109
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.15
, pp. 5785-5790
-
-
Van Raamsdonk, J.M.1
Hekimi, S.2
-
216
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426(6967): 620. doi: 10.1038/426620a
-
(2003)
Nature
, vol.426
, Issue.6967
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
217
-
-
22144462536
-
Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans
-
Ventura N, Rea S, Henderson ST, Condo I, Johnson TE, Testi R (2005) Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans. Aging Cell 4(2): 109-112
-
(2005)
Aging Cell
, vol.4
, Issue.2
, pp. 109-112
-
-
Ventura, N.1
Rea, S.2
Henderson, S.T.3
Condo, I.4
Johnson, T.E.5
Testi, R.6
-
218
-
-
67651174517
-
p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
-
Ventura N, Rea SL, Schiavi A, Torgovnick A, Testi R, Johnson TE (2009) p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell 8 (4): 380-393. doi: 10.1111/j.1474-9726.2009.00482.x
-
(2009)
Aging Cell
, vol.8
, Issue.4
, pp. 380-393
-
-
Ventura, N.1
Rea, S.L.2
Schiavi, A.3
Torgovnick, A.4
Testi, R.5
Johnson, T.E.6
-
219
-
-
80053134340
-
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
-
Viswanathan M, Guarente L (2011) Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477(7365): E1-E2. doi: 10.1038/nature10440
-
(2011)
Nature
, vol.477
, Issue.7365
, pp. E1-E2
-
-
Viswanathan, M.1
Guarente, L.2
-
220
-
-
84884661996
-
Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan
-
Vora M, Shah M, Ostafi S, Onken B, Xue J, Ni JZ, Gu S, Driscoll M (2013) Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan. PLoS Genet 9(8), e1003737. doi: 10.1371/journal.pgen.1003737
-
(2013)
PLoS Genet
, vol.9
, Issue.8
, pp. 1003737
-
-
Vora, M.1
Shah, M.2
Ostafi, S.3
Onken, B.4
Xue, J.5
Ni, J.Z.6
Gu, S.7
Driscoll, M.8
-
221
-
-
79959791906
-
The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans
-
Walter L, Baruah A, Chang HW, Pace HM, Lee SS (2011) The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans. PLoS Biol 9(6), e1001084. doi: 10.1371/journal.pbio.1001084
-
(2011)
PLoS Biol
, vol.9
, Issue.6
, pp. 1001084
-
-
Walter, L.1
Baruah, A.2
Chang, H.W.3
Pace, H.M.4
Lee, S.S.5
-
222
-
-
77957583314
-
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition
-
Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK (2010) RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet 6(8). doi: 10.1371/journal.pgen.1001048
-
(2010)
PLoS Genet
, vol.6
, Issue.8
-
-
Wang, J.1
Robida-Stubbs, S.2
Tullet, J.M.3
Rual, J.F.4
Vidal, M.5
Blackwell, T.K.6
-
223
-
-
55849101681
-
Fat metabolism links germline stem cells and longevity in C. elegans
-
Wang MC, O’Rourke EJ, Ruvkun G (2008) Fat metabolism links germline stem cells and longevity in C. elegans. Science 322(5903): 957-960. doi: 10.1126/science.1162011
-
(2008)
Science
, vol.322
, Issue.5903
, pp. 957-960
-
-
Wang, M.C.1
O’Rourke, E.J.2
Ruvkun, G.3
-
224
-
-
28244475950
-
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
-
Wang Y, Tissenbaum HA (2006) Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech Ageing Dev 127(1): 48-56. doi: 10.1016/j.mad.2005.09.005
-
(2006)
Mech Ageing Dev
, vol.127
, Issue.1
, pp. 48-56
-
-
Wang, Y.1
Tissenbaum, H.A.2
-
225
-
-
33746245679
-
elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
-
Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA (2006). elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev 127(9): 741-747. doi: 10.1016/j.mad.2006.05.005
-
(2006)
Mech Ageing Dev
, vol.127
, Issue.9
, pp. 741-747
-
-
Wang, Y.1
Oh, S.W.2
Deplancke, B.3
Luo, J.4
Walhout, A.J.5
Tissenbaum, H.A.6
-
226
-
-
33644750381
-
SMK-1, an essential regulator of DAF-16-mediated longevity
-
Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A (2006) SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124(5): 1039-1053. doi: 10.1016/j.cell.2005.12.042
-
(2006)
Cell
, vol.124
, Issue.5
, pp. 1039-1053
-
-
Wolff, S.1
Ma, H.2
Burch, D.3
Maciel, G.A.4
Hunter, T.5
Dillin, A.6
-
227
-
-
0346668317
-
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway
-
Wolkow CA, Munoz MJ, Riddle DL, Ruvkun G (2002) Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem 277(51): 49591-49597. doi: 10.1074/jbc.M207866200
-
(2002)
J Biol Chem
, vol.277
, Issue.51
, pp. 49591-49597
-
-
Wolkow, C.A.1
Munoz, M.J.2
Riddle, D.L.3
Ruvkun, G.4
-
228
-
-
84859991779
-
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity
-
Wollam J, Magner DB, Magomedova L, Rass E, Shen Y, Rottiers V, Habermann B, Cummins CL, Antebi A (2012) A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. PLoS Biol 10(4), e1001305. doi: 10.1371/journal.pbio.1001305
-
(2012)
PLoS Biol
, vol.10
, Issue.4
, pp. 1001305
-
-
Wollam, J.1
Magner, D.B.2
Magomedova, L.3
Rass, E.4
Shen, Y.5
Rottiers, V.6
Habermann, B.7
Cummins, C.L.8
Antebi, A.9
-
229
-
-
0028950419
-
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
-
Wong A, Boutis P, Hekimi S (1995) Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139(3): 1247-1259
-
(1995)
Genetics
, vol.139
, Issue.3
, pp. 1247-1259
-
-
Wong, A.1
Boutis, P.2
Hekimi, S.3
-
230
-
-
84874065131
-
A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel
-
Xiao R, Zhang B, Dong Y, Gong J, Xu T, Liu J, Xu XZ (2013) A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell 152(4): 806-817. doi: 10.1016/j.cell.2013.01.020
-
(2013)
Cell
, vol.152
, Issue.4
, pp. 806-817
-
-
Xiao, R.1
Zhang, B.2
Dong, Y.3
Gong, J.4
Xu, T.5
Liu, J.6
Xu, X.Z.7
-
231
-
-
84872016233
-
The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans
-
Xu X, Kim SK (2012) The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans. PLoS Genet 8(12), e1003108. doi: 10.1371/journal.pgen.1003108
-
(2012)
PLoS Genet
, vol.8
, Issue.12
, pp. 1003108
-
-
Xu, X.1
Kim, S.K.2
-
232
-
-
77956821042
-
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling
-
Yamawaki TM, Berman JR, Suchanek-Kavipurapu M, McCormick M, Gaglia MM, Lee SJ, Kenyon C (2010) The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol 8(8). doi: 10.1371/journal.pbio.1000468
-
(2010)
PLoS Biol
, vol.8
, Issue.8
-
-
Yamawaki, T.M.1
Berman, J.R.2
Suchanek-Kavipurapu, M.3
McCormick, M.4
Gaglia, M.M.5
Lee, S.J.6
Kenyon, C.7
-
233
-
-
79960339919
-
The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity
-
Yang CC, Chen D, Lee SS, Walter L (2011) The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell 10 (4): 724-728. doi: 10.1111/j.1474-9726.2011.00711.x
-
(2011)
Aging Cell
, vol.10
, Issue.4
, pp. 724-728
-
-
Yang, C.C.1
Chen, D.2
Lee, S.S.3
Walter, L.4
-
234
-
-
84872616169
-
MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9
-
Yang J, Chen D, He Y, Melendez A, Feng Z, Hong Q, Bai X, Li Q, Cai G, Wang J, Chen X (2013) MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age (Dordr) 35(1): 11-22. doi: 10.1007/s11357-011-9324-3
-
(2013)
Age (Dordr)
, vol.35
, Issue.1
, pp. 11-22
-
-
Yang, J.1
Chen, D.2
He, Y.3
Melendez, A.4
Feng, Z.5
Hong, Q.6
Bai, X.7
Li, Q.8
Cai, G.9
Wang, J.10
Chen, X.11
-
235
-
-
78650455712
-
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
-
Yang W, Hekimi S (2010a) A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol 8(12), e1000556. doi: 10.1371/journal.pbio.1000556
-
(2010)
PLoS Biol
, vol.8
, Issue.12
, pp. 1000556
-
-
Yang, W.1
Hekimi, S.2
-
236
-
-
77956241785
-
Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans
-
ACE571[pii]
-
Yang W, Hekimi S (2010b) Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell 9(3): 433-447, doi: ACE571 [pii]
-
(2010)
Aging Cell
, vol.9
, Issue.3
, pp. 433-447
-
-
Yang, W.1
Hekimi, S.2
-
237
-
-
84900299463
-
The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans
-
Yee C, Yang W, Hekimi S (2014) The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans. Cell 157(4): 897-909. doi: 10.1016/j.cell.2014.02.055
-
(2014)
Cell
, vol.157
, Issue.4
, pp. 897-909
-
-
Yee, C.1
Yang, W.2
Hekimi, S.3
-
238
-
-
33947622592
-
Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia
-
Zarse K, Schulz TJ, Birringer M, Ristow M (2007) Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia. FASEB J 21 (4): 1271-1275. doi: 10.1096/fj.06-6994com
-
(2007)
FASEB J
, vol.21
, Issue.4
, pp. 1271-1275
-
-
Zarse, K.1
Schulz, T.J.2
Birringer, M.3
Ristow, M.4
-
239
-
-
39949084871
-
Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity
-
Zhang Y, Xu J, Puscau C, Kim Y, Wang X, Alam H, Hu PJ (2008) Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Dev Biol 315(2): 290-302. doi: 10.1016/j.ydbio.2007.12.032
-
(2008)
Dev Biol
, vol.315
, Issue.2
, pp. 290-302
-
-
Zhang, Y.1
Xu, J.2
Puscau, C.3
Kim, Y.4
Wang, X.5
Alam, H.6
Hu, P.J.7
-
240
-
-
72949109772
-
Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
-
Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV (2009a) Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol 7(11), e1000245. doi: 10.1371/journal.pbio.1000245
-
(2009)
PLoS Biol
, vol.7
, Issue.11
, pp. 1000245
-
-
Zhang, M.1
Poplawski, M.2
Yen, K.3
Cheng, H.4
Bloss, E.5
Zhu, X.6
Patel, H.7
Mobbs, C.V.8
-
241
-
-
68149149835
-
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans
-
Zhang Y, Shao Z, Zhai Z, Shen C, Powell-Coffman JA (2009b) The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One 4(7), e6348. doi: 10.1371/journal.pone.0006348
-
(2009)
PLoS One
, vol.4
, Issue.7
, pp. 6348
-
-
Zhang, Y.1
Shao, Z.2
Zhai, Z.3
Shen, C.4
Powell-Coffman, J.A.5
|