Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 21, 2010, Pages 9730-9735

  Henis Korenblit, Sivan ^a,b   Zhang, Peichuan ^a   Hansen, Malene ^a,c   McCormick, Mark ^a   Lee, Seung Jae ^a,d   Cary, Michael ^a   Kenyon, Cynthia ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BAR ILAN UNIVERSITY   (Israel)

^c BURNHAM INSTITUTE   (United States)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Aging; daf 2; Insulin signaling; Unfolded protein response

Indexed keywords

INOSITOL REQUIRING PROTEIN 1; INSULIN; MESSENGER RNA; RIBONUCLEASE; SOMATOMEDIN C; TRANSCRIPTION FACTOR DAF 16; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ARTICLE; CAENORHABDITIS ELEGANS; DAF 2 GENE; DOX 1 GENE; ENDOPLASMIC RETICULUM STRESS; GENE; LIFE EXTENSION; LONGEVITY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA SPLICING;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; ENDOPLASMIC RETICULUM; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, INSULIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

CAENORHABDITIS ELEGANS;

EID: 77953091249     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002575107     Document Type: Article

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