Fat metabolism links germline stem cells and longevity in C. elegans

Science

Volumn 322, Issue 5903, 2008, Pages 957-960

  Wang, Meng C ^a   O'Rourke, Eyleen J ^a   Ruvkun, Gary ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; TRIACYLGLYCEROL LIPASE;

AGING; FAT; HORMONE; LIPID; LONGEVITY; METABOLISM; NEMATODE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CELL CYCLE ARREST; ENZYME INDUCTION; GERM LINE; LIPID HYDROLYSIS; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; GENES, HELMINTH; GERM CELLS; HYDROLYSIS; INTESTINES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPASE; LIPID METABOLISM; LONGEVITY; MODELS, ANIMAL; RECEPTOR, INSULIN; REPRODUCTION; SIGNAL TRANSDUCTION; STEM CELLS; TEMPERATURE; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 55849101681     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1162011     Document Type: Article

References (25)

1. R. Zechner, J. G. Strauss, G. Haemmerle, A. Lass, R. Zimmermann, Curr. Opin. Lipidol. 16, 333 (2005).
2. H. A. Tissenbaum, G. Ruvkun, Genetics 148, 703 (1998).
3. D. J. Burks et al., Nature 407, 377 (2000).
4. M. C. Carr, J. Clin. Endocrinol. Metab. 88, 2404 (2003).
5. M. Blüher, B. B. Kahn, C. R. Kahn, Science 299, 572 (2003).
6. D. S. Hwangbo, B. Gershman, M. P. Tu, M. Palmer, M. Tatar, Nature 429, 562 (2004).
7. M. E. Giannakou et al., Science 305, 361 (2004); published online 10 June 2004 (10.1126/science.1098219).
8. N. Arantes-Oliveira, J. Apfeld, A. Dillin, C. Kenyon, Science 295, 502 (2002).
9. K. Ashrafi et al., Nature 421, 268 (2003).
10. M. J. Beanan, S. Strome, Development 116, 755 (1992).
11. J. R. Priess, H. Schnabel, R. Schnabel, Cell 51, 601 (1987).
12. H. Y. Mak, L. S. Nelson, M. Basson, C. D. Johnson, G. Ruvkun, Nat. Genet. 38, 363 (2006).
13. S. Ogg et al., Nature 389, 994 (1997).
14. J. Hodgkin, Genetics 114, 15 (1986).
15. M. K. Barton, T. B. Schedl, J. Kimble, Genetics 115, 107 (1987).
16. J. E. Kimble, J. G. White, Dev. Biol. 81, 208 (1981).
17. M. D. Wong, Z. Jin, T. Xie, Annu. Rev. Genet. 39, 173 (2005).
18. S. T. Henderson, D. Gao, E. J. Lambie, J. Kimble, Development 120, 2913 (1994).
19. A. S. Pepper, D. J. Killian, E. J. Hubbard, Genetics 163, 115 (2003).
20. R. Francis, E. Maine, T. Schedl, Genetics 139, 607 (1995).
21. J. R. Berman, C. Kenyon, Cell 124, 1055 (2006).
22. S. S. Lee, S. Kennedy, A. C. Tolonen, G. Ruvkun, Science 300, 644 (2003); published online 10 April 2003 (10.1126/science.1083614) .
23. S. Wolff et al., Cell 124, 1039 (2006).
24. C. A. Wolkow, K. D. Kimura, M.-S. Lee, G. Ruvkun, Science 290, 147 (2000).
25. We thank H. Mak, J. Dittman, and J. Avruch for critical reading of the manuscript; N. Ringstad for laser ablation techniques; V. Rottiers, A. Antebi, and the Caenorhabditis Genetics Center for providing strains; A. Fire for GFP vectors; and members of the Ruvkun lab for discussions. Supported by Life Sciences Research Foundation and Ellison Medical Foundation fellowships (M.C.W.), a Human Frontier Science Program fellowship (E.J.O.), and NIH grants 5R01AG016636 and 5R37AG14161 (G.R.).