Superoxide dismutase is dispensable for normal animal lifespan

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 15, 2012, Pages 5785-5790

  Van Raamsdonk, Jeremy Michael ^a   Hekimi, Siegfried ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Free radical theory of aging; Oxidative stress; Reactive oxygen species mediated signaling; Sod 2

Indexed keywords

SUPEROXIDE DISMUTASE;

ARTICLE; CAENORHABDITIS ELEGANS; ENZYME ACTIVITY; GENE DELETION; LIFESPAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SURVIVAL;

AEROBIOSIS; ANIMALS; CAENORHABDITIS ELEGANS; GENES, REPORTER; GENOTYPE; LONGEVITY; MUTATION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; SUPEROXIDE DISMUTASE; SUPEROXIDES; SURVIVAL ANALYSIS;

ANIMALIA; CAENORHABDITIS ELEGANS; EUKARYOTA;

EID: 84859575436     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116158109     Document Type: Article

References (36)

1. Harman D (1956) Aging: A theory based on free radical and radiation chemistry. J Gerontol 11:298-300.
2. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H (2007) Trends in oxidative aging theories. Free Radic Biol Med 43:477-503. (Pubitemid 47058228)
3. Van Raamsdonk JM, Hekimi S (2010) Reactive oxygen species and aging in Caenorhabditis elegans: Causal or casual relationship? Antioxid Redox Signal 13:1911-1953.
4. Hekimi S, Lapointe J, Wen Y (2011) Taking a "good" look at free radicals in the aging process. Trends Cell Biol 21:569-576.
5. Fridovich I (1978) The biology of oxygen radicals. Science 201:875-880.
6. Jenney FE, Jr., Verhagen MF, Cui X, Adams MW (1999) Anaerobic microbes: Oxygen detoxification without superoxide dismutase. Science 286:306-309. (Pubitemid 29484696)
7. Archibald FS, Fridovich I (1981) Manganese and defenses against oxygen toxicity in Lactobacillus plantarum. J Bacteriol 145:442-451. (Pubitemid 11140325)
8. Longo VD, Liou LL, Valentine JS, Gralla EB (1999) Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365:131-142. (Pubitemid 29394258)
9. Longo VD, Gralla EB, Valentine JS (1996) Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271:12275-12280. (Pubitemid 26160890)
10. Wawryn J, Krzepiłko A, Myszka A, Biliński T (1999) Deficiency in superoxide dismutases shortens life span of yeast cells. Acta Biochim Pol 46:249-253.
11. Unlu ES, Koc A (2007) Effects of deleting mitochondrial antioxidant genes on life span. Ann.N.Y. Acad.Sci. 1100:505-509. (Pubitemid 47092689)
12. Phillips JP, Campbell SD, Michaud D, Charbonneau M, Hilliker AJ (1989) Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc Natl Acad Sci USA 86:2761-2765. (Pubitemid 19112621)
13. Kirby K, Hu J, Hilliker AJ, Phillips JP (2002) RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. Proc Natl Acad Sci USA 99:16162-16167. (Pubitemid 35462766)
14. Duttaroy A, Paul A, Kundu M, Belton A (2003) A Sod2 null mutation confers severely reduced adult life span in Drosophila. Genetics 165:2295-2299. (Pubitemid 38040309)
15. Elchuri S, et al. (2005) CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 24:367-380. (Pubitemid 40188585)
16. Li Y, et al. (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11:376-381.
17. Lebovitz RM, et al. (1996) Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 93: 9782-9787. (Pubitemid 26296686)
18. Doonan R, et al. (2008) Against the oxidative damage theory of aging: Superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev 22:3236-3241.
19. Yen K, Patel HB, Lublin AL, Mobbs CV (2009) SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mech Ageing Dev 130:173-178.
20. Yanase S, Onodera A, Tedesco P, Johnson TE, Ishii N (2009) SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation. J Gerontol A Biol Sci Med Sci 64:530-539.
21. Honda Y, Tanaka M, Honda S (2008) Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans. Exp Gerontol 43:520-529.
22. Van Raamsdonk JM, Hekimi S (2009) Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 5:e1000361.
23. Hassett DJ, Schweizer HP, Ohman DE (1995) Pseudomonas aeruginosa sodA and sodB mutants defective in manganese- and iron-cofactored superoxide dismutase activity demonstrate the importance of the iron-cofactored form in aerobic metabolism. J Bacteriol 177:6330-6337.
24. Carlioz A, Touati D (1986) Isolation of superoxide dismutase mutants in Escherichia coli: Is superoxide dismutase necessary for aerobic life? EMBO J 5:623-630.
25. Shibata Y, Branicky R, Landaverde IO, Hekimi S (2003) Redox regulation of germline and vulval development in Caenorhabditis elegans. Science 302:1779-1782. (Pubitemid 37505744)
26. Lithgow GJ, Miller RA (2008) The determination of aging rate by coordinated resistance to multiple forms of stress. The Molecular Biology of Aging, eds Guarente L, Partridge L, Wallace DC (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY).
27. Sturtz LA, Diekert K, Jensen LT, Lill R, Culotta VC (2001) A fraction of yeast Cu,Znsuperoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. J Biol Chem 276:38084-38089.
28. Yang W, Li J, Hekimi S (2007) A measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. Genetics 177:2063-2074. (Pubitemid 350276988)
29. Yang W, Hekimi S (2010) A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol 8:e1000556.
30. Lee SJ, Hwang AB, Kenyon C (2010) Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol 20(23):2131-2136.
31. Walter L, Baruah A, Chang HW, Pace HM, Lee SS (2011) The homeobox protein CEH- 23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans. PLoS Biol 9:e1001084.
32. Feng J, Bussière F, Hekimi S (2001) Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 1:633-644. (Pubitemid 33586116)
33. Tawe WN, Eschbach ML, Walter RD, Henkle-Dührsen K (1998) Identification of stressresponsive genes in Caenorhabditis elegans using RT-PCR differential display. Nucleic Acids Res 26:1621-1627. (Pubitemid 28291795)
34. Link CD, Johnson CJ (2002) Reporter transgenes for study of oxidant stress in Caenorhabditis elegans. Methods Enzymol 353:497-505. (Pubitemid 34625615)
35. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
36. Van Raamsdonk JM, et al. (2010) Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage. Genetics 185:559-571.