Long-lived C. elegans daf-2 Mutants are resistant to bacterial pathogens

Science

Volumn 300, Issue 5627, 2003, Pages 1921-

  Garsin, Danielle A ^a   Villanueva, Jacinto M ^a   Begun, Jakob ^a   Kim, Dennis H ^a   Sifri, Costi D ^a   Calderwood, Stephen B ^a   Ruvkun, Gary ^a   Ausubel, Frederick M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR;

BACTERIUM; MUTATION; PATHOGEN;

ARTICLE; CAENORHABDITIS ELEGANS; ENTEROCOCCUS FAECALIS; IMMUNE RESPONSE; IMMUNITY; INFECTION RESISTANCE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA; STAPHYLOCOCCUS AUREUS; SURVIVAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALLELES; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; LONGEVITY; MUTATION; PHENOTYPE; RECEPTOR, INSULIN; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION FACTORS;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; ENTEROCOCCUS FAECALIS; INVERTEBRATA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA; STAPHYLOCOCCUS AUREUS;

EID: 0038047438     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080147     Document Type: Article

References (10)

1. C. E. Finch, G. Ruvkun, Annu. Rev. Genomics Hum. Genet. 2, 435 (2001).
2. C. A. Wolkow, K. D. Kimura, M.-S. Lee, G. Ruvkun, Science 290, 147 (2000).
3. D. H. Kim et al., Science 297, 623 (2002).
4. A, Aballay, F. M. Ausubel, Curr. Opin. Microbiol. 5, 97 (2002).
5. D. A. Garsin et al., Proc. Natl. Acad. Sci. U.S.A. 98, 10892 (2001).
6. D. Garigan et al., Genetics 161, 1101 (2002).
7. G. V. Mallo et al., Curr. Biol. 12, 1209 (2002).
8. The difference in life-span between feeding on E. coli OP50 and B. subtilis PY79 was particularly dramatic when the longevity assays were carried out at 27°C rather than at 25°C; the worms lived almost 100% longer on B. subtilis then they did on E. coli (table S1).
9. 50 values (amount of time for 50% of worms to die) shown in table S1.
10. We thank S. Lee and R. Feinbaum for helpful discussions and critical reading of the manuscript D.A.G. and J.M.V. are supported by postdoctoral fellowships from the lrvington Institute for Immunological Research. C.D.S. and D.H.K. are supported by postdoctoral fellowships from the Howard Hughes Medical Institute. This work was supported by NIH grant GM48707 (to F.M.A.).